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01-03-2017 | Original Paper

CEACAM1 is overexpressed in oral tumors and related to tumorigenesis

Authors: Fu-fang Wang, Bing-xin Guan, Jing-yan Yang, Hai-tao Wang, Cheng-jun Zhou

Published in: Medical Molecular Morphology | Issue 1/2017

Abstract

Carcinoembryonic antigen-related adhesion molecule 1 (CEACAM1) is a type 1 transmembrane glycoprotein belonging to the CEA family, which has been known to exist as either soluble forms in body fluids or membrane-bound forms on the cell surface. Aberrant CEACAM1 expression is associated with tumorigenesis and has been reported in a variety of human tumors, especially malignancies. The aim of this study is to determine the expression of CEACAM1 in oral tumors, trying to study CEACAM1 different expressions as a function of histotype. CEACAM1 expression was observed by immunohistochemistry (IHC) with mouse anti-human antibody for CEACAM1. IHC was performed using avidin–biotin-diaminobenzidine staining. The results were expressed as average score ± SD (0 = negative/8 = highest) for each histotype. Oral tumors expressed more CEACAM1 than normal tissues including squamous and salivary epithelia (P < 0.05). In malignancies, the squamous cell carcinoma overexpressed CEACAM1, compared to well-differentiated squamous cell with more membranous expression; the intermediately and poorly differentiated squamous cell carcinoma showed more cytoplasmic expression (P < 0.05). In addition, the salivary tumors significantly expressed more CEACAM1 than squamous cell carcinoma (P < 0.05). So, we thought oral tumors overexpressed CEACAM1 and the cytoplasmic CEACAM1 might be involved in tumorigenesis, and also CEACAM1 might be regarded as a marker of salivary glandular tumors.

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Title: CEACAM1 is overexpressed in oral tumors and related to tumorigenesis
Authors: Fu-fang Wang
Bing-xin Guan
Jing-yan Yang
Hai-tao Wang
Cheng-jun Zhou
Publication date: 01-03-2017
Publisher: Springer Japan
Published in: Medical Molecular Morphology / Issue 1/2017
Print ISSN: 1860-1480
Electronic ISSN: 1860-1499
DOI: https://doi.org/10.1007/s00795-016-0147-2

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CEACAM1 is overexpressed in oral tumors and related to tumorigenesis

Abstract

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Abstract

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