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01-06-2019 | Original Contribution

Increased right amygdala metabolite concentrations in the absence of atrophy in children and adolescents with PTSD

Authors: Weina Wang, Huaiqiang Sun, Xiaorui Su, Qiaoyue Tan, Simin Zhang, Chunchao Xia, Lingjiang Li, Graham J. Kemp, Qiang Yue, Qiyong Gong

Published in: European Child & Adolescent Psychiatry | Issue 6/2019

Abstract

Previous studies have shown that posttraumatic stress disorder (PTSD) is associated with dysfunction of the limbic system, in which the amygdala plays an important role. The purpose of this study was to evaluate whether the neurochemical concentrations assessed by proton magnetic resonance spectroscopy (¹H-MRS) in the amygdala are abnormal in children and adolescents with PTSD. Twenty-eight pediatric PTSD patients (11 boys, 17 girls) and 24 matched trauma-exposed control subjects (9 boys, 15 girls) underwent magnetic resonance brain imaging and ¹H-MRS of the bilateral amygdalae. The concentrations of N-acetylaspartate (NAA), myo-inositol (mI), total creatine (tCr) and total choline (tCho) in the right amygdala were significantly increased in PTSD patients compared with trauma-exposed control subjects. There were significant group-by-age interactions in the left amygdala NAA and right amygdala mI concentrations: older pediatric patients with PTSD had higher left amygdala NAA concentration and younger patients had higher right amygdala mI concentration than trauma-exposed control subjects. There was also a significant correlation between right mI concentration and time since trauma in PTSD patients. Finally, there was significant group-by-age interaction in the left amygdala volume; intragroup analysis revealed that the right amygdala volume was significantly lower than the left in the PTSD group, but not in the control group. These neurochemical abnormalities of the amygdala may indicate that dysfunctions of both neurons and glial cells are involved in the pathology of pediatric PTSD.

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Title: Increased right amygdala metabolite concentrations in the absence of atrophy in children and adolescents with PTSD
Authors: Weina Wang
Huaiqiang Sun
Xiaorui Su
Qiaoyue Tan
Simin Zhang
Chunchao Xia
Lingjiang Li
Graham J. Kemp
Qiang Yue
Qiyong Gong
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Published in: European Child & Adolescent Psychiatry / Issue 6/2019
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-018-1241-x

Keynote webinar | Spotlight on medication adherence

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Increased right amygdala metabolite concentrations in the absence of atrophy in children and adolescents with PTSD

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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