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Published in: European Child & Adolescent Psychiatry 3/2010

Open Access 01-03-2010 | Review

Genetics of autistic disorders: review and clinical implications

Authors: Christine M. Freitag, Wouter Staal, Sabine M. Klauck, Eftichia Duketis, Regina Waltes

Published in: European Child & Adolescent Psychiatry | Issue 3/2010

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Abstract

Twin and family studies in autistic disorders (AD) have elucidated a high heritability of AD. In this literature review, we will present an overview on molecular genetic studies in AD and highlight the most recent findings of an increased rate of copy number variations in AD. An extensive literature search in the PubMed database was performed to obtain English published articles on genetic findings in autism. Results of linkage, (genome wide) association and cytogenetic studies are presented, and putative aetiopathological pathways are discussed. Implications of the different genetic findings for genetic counselling and genetic testing at present will be described. The article ends with a prospectus on future directions.
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Metadata
Title
Genetics of autistic disorders: review and clinical implications
Authors
Christine M. Freitag
Wouter Staal
Sabine M. Klauck
Eftichia Duketis
Regina Waltes
Publication date
01-03-2010
Publisher
Springer-Verlag
Published in
European Child & Adolescent Psychiatry / Issue 3/2010
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-009-0076-x

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