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European Child & Adolescent Psychiatry

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Open Access 01-09-2007 | ORIGINAL CONTRIBUTION

Childbirth complications affect young infants’ behavior

Authors: Carolina de Weerth, PhD, Jan K. Buitelaar, MD, PhD

Published in: European Child & Adolescent Psychiatry | Issue 6/2007

Abstract

Background

The process of childbirth and its complications have been related to the newborn’s condition and to development at later ages. In this study, we examine how mode of delivery and delivery complications are related to the behavior and cortisol reactivity of infants during the first 2 months.

Methods

Delivery factors (i.e. mode, duration, fetal heart function, and 5−min Apgar score) were determined in 116 healthy, term, firstborn infants. The infants’ behavioral and cortisol reactivity to stressors were assessed during a physical examination at 11 days and an inoculation at 2 months. Daily behavior at 6 weeks was followed by means of a four-day parental diary.

Results

Indicators of a more stressful delivery were linked to more crying/fussing in the infant and to more difficulties in regulating the infants’ behavior (i.e., more unsoothability and longer crying bouts). Specific delivery complications rather than mode of delivery were linked to infants’ behavior. No significant associations however, were found between childbirth and the infants’ cortisol reactivity to a physical examination and an inoculation.

Conclusions

Childbirth complications, even when mild, can apparently affect early infant behavior. These effects extend over different types of situations, and last at least until the age of 2 months, and should be taken into account in studies on infant behavior. Earlier findings of relations between childbirth complications and infant cortisol reactivity could not be replicated in this study, possibly due to the confounding effect of parity, and to the important intra-individual variability present in the infants’ cortisol.

Barr RG, Kramer MS, Boisjoly C, McVey-White L, Pless IB (1988) Parental diary of infant cry and fuss behaviour. Arch Dis Childhood 63:380–387CrossRef

de Weerth C, van Geert P, Hoijtink H (1999) Intra-individual variability in infant behavior. Dev Psychol 35:1102–1112PubMedCrossRef

de Weerth C, van Geert P (2002) A longitudinal study of basal cortisol in infants: Intra-individual variability, circadian rhythm and developmental trends. Infant Behav Dev 25:375–398CrossRef

de Weerth C, Graat G, Buitelaar JK, Thijssen JH (2003) Measurement of cortisol in small quantities of saliva. Clin Chem 49:658–660PubMedCrossRef

de Weerth C, Zijl RH, Buitelaar JK (2003) Development of cortisol circadian rhythm in infancy. Early Hum Dev 73:39–52PubMedCrossRef

Gitau R, Menson E, Pickles V, Fisk NM, Glover V, MacLachlan N (2001) Umbilical cortisol levels as an indicator of the fetal stress response to assisted vaginal delivery. Eur J Obstet Gynecol Reprod Biol 98:14–17PubMedCrossRef

Grajeda R, Perez-Escamilla R (2002) Stress during labor and delivery is associated with delayed onset of lactation among urban Guatemalan women. J Nutr 132:3055–3060PubMed

Gunnar MR, Nelson CA (1994) Event-related potentials in year-old infants: relations with emotionality and cortisol. Child Dev 65:80–94PubMedCrossRef

Gunnar MR, Brodersen L, Krueger K, Rigatuso J (1996) Dampening of adrenocortical responses during infancy: normative changes and individual differences. Child Dev 67:877–889PubMedCrossRef

10.

Hadders-Algra M, Huisjes HJ, Touwen BC (1988) Perinatal correlates of major and minor neurological dysfunction at school age: a multivariate analysis. Dev Med Child Neurol 30:472–481PubMedCrossRef

11.

Keenan K, Grace D, Gunthorpe D (2003) Examining stress reactivity in neonates: relations between cortisol and behavior. Child Dev 74:1930–1942PubMedCrossRef

12.

Keller H, Lohaus A, Volker S, Cappenberg M, Chasiotis A (1998) Relationships between infant crying, birth complications, and maternal variables. Child Care Health Dev 24:377–394PubMedCrossRef

13.

Lewis M, Ramsay DS (1995) Developmental change in infants’ responses to stress. Child Dev 66:657–670PubMedCrossRef

14.

Lewis M, Ramsay D (2005) Infant emotional and cortisol responses to goal blockage. Child Dev 76:518–530PubMedCrossRef

15.

Linden W, Earle TL, Gerin W, Christenfeld N (1997) Physiological stress reactivity and recovery: conceptual siblings separated at birth? J Psychosom Res 42:117–135PubMedCrossRef

16.

Miller NM, Fisk NM, Modi N, Glover V (2005) Stress responses at birth: determinants of cord arterial cortisol and links with cortisol response in infancy. BJOG 112:921–926PubMedCrossRef

17.

Pohjavuori M, Rovamo L, Laatikainen T (1985) Plasma immunoreactive beta-endorphin and cortisol in the newborn infant after elective caesarean section and after spontaneous labour. Eur J Obstet Gynecol Reproduct Biol 19:67–74CrossRef

18.

Prechtl HFR (1977) The neurological examination of the full-term newborn infant. Clinics in developmental medicine, nr. 63. Lavenham Press, Suffolk

19.

Ramsay DS, Lewis M (1995) The effects of birth condition on infants’ cortisol response to stress. Pediatrics 95:546–549PubMed

20.

Roy MP (2004) Patterns of cortisol reactivity to laboratory stress. Hormones Behav 46:618–627CrossRef

21.

Soorani-Lunsing RJ, Hadders-Algra M, Huisjes HJ, Touwen BC (1993) Minor neurological dysfunction after the onset of puberty: association with perinatal events. Early Hum Dev 33:71–80PubMedCrossRef

22.

Taddio A, Katz J, Ilersich AL, Koren G (1997) Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet 349:599–603PubMedCrossRef

23.

Taddio A, Shah V, Gilbert-MacLeod C, Katz J (2002) Conditioning and hyperalgesia in newborns exposed to repeated heel lances. JAMA 288:857–861PubMedCrossRef

24.

Taylor A, Fisk NM, Glover V (2000). Mode of delivery and subsequent stress response. Lancet 355:120PubMedCrossRef

25.

Thijssen JHH, Van den Berg JHM, Adlercreutz H, Gijzen AHJ, de Jong FH, Moolenaar AJ (1980) The determination of cortisol in human plasma: evaluation and comparison of seven assays. Clin Chim Acta 100:39–46PubMedCrossRef

26.

van den Berg A, van Elburg RM, van Geijn HP, Fetter WP (2001) Neonatal respiratory morbidity following elective caesarean section in term infants. A 5-year retrospective study and a review of the literature. Eur J Obstet Gynecol Reproduct Biol 98:9–13CrossRef

27.

Ziadeh SM, Sunna E (2000) Obstetric and perinatal outcome of pregnancies with term labour and meconium-stained amniotic fluid. Arch Gynecol Obstet 264:84–87PubMedCrossRef

Title: Childbirth complications affect young infants’ behavior
Authors: Carolina de Weerth, PhD
Jan K. Buitelaar, MD, PhD
Publication date: 01-09-2007
Publisher: D. Steinkopff-Verlag
Published in: European Child & Adolescent Psychiatry / Issue 6/2007
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-007-0610-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Childbirth complications affect young infants’ behavior

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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