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European Child & Adolescent Psychiatry
Published in: European Child & Adolescent Psychiatry 8/2006

01-12-2006 | BRIEF REPORT

Increased mRNA levels of the mitochondrial complex I 75-kDa subunit

A potential peripheral marker of early onset schizophrenia?

Authors: Claudia Mehler-Wex, MD, J. Catharina Duvigneau, Romana T. Hartl, Dorit Ben-Shachar, Andreas Warnke, Manfred Gerlach

Published in: European Child & Adolescent Psychiatry | Issue 8/2006

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Abstract

Recently, the dopamine D3-receptor mRNA on blood lymphocytes and platelet mitochondrial complex I were suggested as biological markers of schizophrenia in adults. We investigated the mRNA level of the dopamine D3-receptor and complex I subunits in whole blood cells of early-onset schizophrenic patients compared to healthy controls using quantitative real-time PCR. We found an increased mRNA expression of the complex I 75-kDa subunit (referred to beta-actin in schizophrenic patients (0.57 ± 0.24 versus 0.23 ± 0.18 in controls, P < 0.01)), but were unable to analyse the dopamine D3-mRNA expression. This increase appears to be inherent to schizophrenia, because it was found in neuroleptic-naive patients and it was not affected by neuroleptic treatment. Our preliminary findings suggest the mitochondrial complex I as a potential peripheral marker of schizophrenia and its involvement in the pathophysiology of this illness.
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Metadata
Title
Increased mRNA levels of the mitochondrial complex I 75-kDa subunit
A potential peripheral marker of early onset schizophrenia?
Authors
Claudia Mehler-Wex, MD
J. Catharina Duvigneau
Romana T. Hartl
Dorit Ben-Shachar
Andreas Warnke
Manfred Gerlach
Publication date
01-12-2006
Publisher
Steinkopff-Verlag
Published in
European Child & Adolescent Psychiatry / Issue 8/2006
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-006-0560-5

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