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Open Access 01-01-2024 | Bleeding on Probing | Research

Targeted proteomics in a population-based study identifies serum PECAM-1 and TRIM21 as inflammation markers for periodontitis

Authors: Stefan Lars Reckelkamm, Inga Kamińska, Sebastian-Edgar Baumeister, Mariana Ponce-de-Leon, Benjamin Ehmke, Ewa Rodakowska, Joanna Baginska, Michael Nolde, Karol Adam Kamiński

Published in: Clinical Oral Investigations | Issue 1/2024

Abstract

Objectives

Periodontitis (PD) can cause systematic inflammation and is associated with various metabolic processes in the body. However, robust serum markers for these relationships are still lacking. This study aims to identify novel circulating inflammation-related proteins associated with PD using targeted proteomics.

Materials and methods

We used population-based, cross-sectional data from 619 participants of the Polish Longitudinal University Study (Bialystok PLUS). Mean pocket probing depth (mPPD) and proportion of bleeding on probing (pBOP) served as exposure variables. Fifty-two inflammation-related proteins were measured using the Olink Target 96 Cardiovascular III and the Olink Target 96 Immune Response panels. Associations between periodontal measures and proteins were tested using covariate-adjusted linear regression models.

Results

At a false discovery rate of < 0.05, we identified associations of mPPD and pBOP with platelet-endothelial cell adhesion molecule-1 (PECAM-1) and tripartite motif–containing protein 21 (TRIM21).

Conclusion

This study revealed novel associations between PD and serum levels of PECAM-1 and TRIM21. Our results suggest that these proteins might be affected by molecular processes that take place in the inflamed periodontium.

Clinical relevance

Novel associations of PECAM-1 and TRIM21 with PD indicate promising serum markers for understanding the disease’s pathophysiological processes and call for further biomedical investigations.

Available only for authorised users

Olink Proteomics, Uppsala, Sweden

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Title: Targeted proteomics in a population-based study identifies serum PECAM-1 and TRIM21 as inflammation markers for periodontitis
Authors: Stefan Lars Reckelkamm
Inga Kamińska
Sebastian-Edgar Baumeister
Mariana Ponce-de-Leon
Benjamin Ehmke
Ewa Rodakowska
Joanna Baginska
Michael Nolde
Karol Adam Kamiński
Publication date: 01-01-2024
Publisher: Springer Berlin Heidelberg
Keyword: Bleeding on Probing
Published in: Clinical Oral Investigations / Issue 1/2024
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05442-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Targeted proteomics in a population-based study identifies serum PECAM-1 and TRIM21 as inflammation markers for periodontitis

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

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