Published in:
Open Access
17-08-2023 | Digital Volume Tomography | Research
Effects of mandibular advancement devices on upper airway dimensions in obstructive sleep apnea: responders versus non-responders
Authors:
Xiaoxin Shi, Frank Lobbezoo, Hui Chen, Boudewijn R. A. M. Rosenmöller, Erwin Berkhout, Jan de Lange, Ghizlane Aarab
Published in:
Clinical Oral Investigations
|
Issue 9/2023
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Abstract
Study objectives
To compare the effects of mandibular advancement device (MAD) therapy on upper airway dimensions between responders and non-responders with mild to moderate obstructive sleep apnea (OSA).
Methods
Thirty-one participants (21 men and 10 women) with a mean ± SD apnea-hypopnea index (AHI) of 16.6 ± 6.7 events/h, and aged 48.5 ± 13.9 years, were included in this study. Polysomnographic recordings and cone beam computed tomography (CBCT) scans in supine position were performed for every participant at baseline and at 3-month follow-up with their MAD in situ. Responders were defined as having ≥ 50% reduction in baseline AHI with a residual AHI < 10 events/h. The primary outcome variable was the minimal cross-sectional area of the upper airway (CSAmin).
Results
No significant differences were found between responders (n = 15) and non-responders (n = 16) in age, gender distribution, body mass index, and neck circumference (P = 0.06–0.93), nor in AHI and CSAmin (P = 0.40 and 0.65, respectively) at baseline. The changes of the CSAmin with MAD in situ in the responder group were not significantly different compared to those in the non-responder group (P = 0.06).
Conclusion
Within the limitations of this study, we conclude that the changes of the upper airway dimensions induced by MADs are not significantly different between responders and non-responders with mild to moderate OSA.