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Clinical Oral Investigations

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31-07-2023 | Arterial Occlusive Disease | Research

Effect of endodontic treatment on endothelial dysfunction and subclinical atherosclerosis—a prospective intervention study

Authors: Nishant Chauhan, Shweta Mittal, Sanjay Tewari, Jyotsna Sen, Kuldip Laller

Published in: Clinical Oral Investigations | Issue 9/2023

Abstract

Objective

The objective of this study is to investigate the effect of endodontic treatment on flow-mediated dilatation (FMD) and carotid intima-media thickness (c-IMT) in patients with apical periodontitis (AP).

Material and method

The study includes 32 young men having AP with a mean age of 25.78 years free from cardiovascular disease (CVD) and its risk factors, including periodontitis. All subjects underwent complete physical and dental examination, echocardiography, and ultrasound assessment of FMD on the brachial artery and c-IMT on the carotid artery at baseline and 12 months after the endodontic treatment. Data were analyzed using paired Student’s t-test and Pearson’s correlation coefficient (r) test using SPSS 26 version.

Results

Endodontic treatment leads to the improvement of FMD significantly from a pooled baseline value of 4.84 ± 1.55% to 7.68 ± 2.08% (p < 0.05). The study also depicts a statistically significant difference between c-IMT (mean = 0.62 ± 0.11 mm) before treatment as compared to 12 months after treatment (mean = 0.59 ± 0.11 mm) (p < 0.05).

Conclusion

Endodontic treatment leads to improved FMD and decreased c-IMT suggesting that treating AP can be help revert the early stages of CVD.

Clinical relevance

AP could be a potential etiological factor of future CVD and should be treated as soon as diagnosed.

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Title: Effect of endodontic treatment on endothelial dysfunction and subclinical atherosclerosis—a prospective intervention study
Authors: Nishant Chauhan
Shweta Mittal
Sanjay Tewari
Jyotsna Sen
Kuldip Laller
Publication date: 31-07-2023
Publisher: Springer Berlin Heidelberg
Keyword: Arterial Occlusive Disease
Published in: Clinical Oral Investigations / Issue 9/2023
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05183-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of endodontic treatment on endothelial dysfunction and subclinical atherosclerosis—a prospective intervention study

Abstract

Objective

Material and method

Results

Conclusion

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Material and method

Results

Conclusion

Clinical relevance

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