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Clinical Oral Investigations
Published in: Clinical Oral Investigations 9/2023

Open Access 28-07-2023 | Research

Use and efficacy of dry-mouth interventions in Sjögren’s disease patients and possible association with perceived oral dryness and patients’ discomfort

Authors: Z. Assy, J. S. van Santen, H. S. Brand, F. J. Bikker

Published in: Clinical Oral Investigations | Issue 9/2023

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Abstract

Objectives

Sjögren’s disease (SjD) patients use various interventions to relief their oral dryness. However, the use and efficacy of these interventions have only partially been evaluated. The present study aims to investigate whether there is an association between the perceived oral dryness and discomfort of SjD patients and their use of specific interventions.

Materials and methods

A cross-sectional study was performed among SjD patients, who completed several questionnaires to assess the severity of their oral dryness and an inventory of dry-mouth interventions. The perceived efficacy of each intervention was reported on a 5-point Likert-scale.

Results

The questionnaires were returned by 92 SjD patients. For relief of oral dryness, they mostly used “eating fruit”, “drinking tea”, “moistening the lips”, “drinking water, and “drinking small volumes” (> 50%). Three interventions had a frequency of use ranging from 2–6 times/day, whereas, “drinking water” and “drinking small volumes” showed higher frequencies (> 14). The highest overall efficacy (≥ 3.5) was reported for “chewing gum” and “using a mouth gel”. Furthermore, various dry-mouth interventions showed significant associations with oral dryness scores and/or patients’ discomfort. For example, “drinking small volumes” and “using XyliMelts” were associated with the Bother Index score.

Conclusion

Great variation was found in the use of dry-mouth interventions by the participants and the severity of the oral dryness and/or patients’ discomfort seemed to affect their choice of intervention. Notably, the mostly used interventions did not show the highest reported efficacy.

Clinical relevance

These findings might help SjD patients and clinicians in their choice of effective dry-mouth interventions.
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Literature
1.
Roblegg E, Coughran A, Sirjani D (2019) Saliva: an all-rounder of our body. Eur J Pharm Biopharm 142:133–141CrossRefPubMed
2.
Saleh J, Figueiredo MA, Cherubini K, Salum FG (2015) Salivary hypofunction: an update on aetiology, diagnosis and therapeutics. Arch Oral Biol 60(2):242–55CrossRefPubMed
3.
Al Hamad A, Lodi G, Porter S, Fedele S, Mercadante V (2019) Interventions for dry mouth and hyposalivation in Sjögren’s syndrome: a systematic review and meta-analysis. Oral Dis 25(4):1027–47CrossRefPubMed
4.
5.
Assy Z, Bikker FJ, Picauly O, Brand HS (2022) The association between oral dryness and use of dry-mouth interventions in Sjögren’s syndrome patients. Clin Oral Inv 26(2):1465–75CrossRef
6.
7.
Pijpe J, Kalk WWI, Bootsma H, Spijkervet FKL, Kallenberg CGM, Vissink A (2007) Progression of salivary gland dysfunction in patients with Sjogren’s syndrome. Ann Rheum Dis 66(1):107–112CrossRefPubMed
8.
Burgess J, Lee P (2012) XyliMelts time-release adhering discs for night-time oral dryness. Int J Dent Hyg 10(2):118–121CrossRefPubMed
9.
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP (2014) The Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg (London, England) 12(12):1495–9CrossRef
10.
Thomson WM, Chalmers JM, Spencer AJ, Williams SM (1999) The xerostomia inventory: a multi-item approach to measuring dry mouth. Community Dental Health 16(1):12–7PubMed
11.
Bulthuis MS, Jan Jager DH, Brand HS (2018) Relationship among perceived stress, xerostomia, and salivary flow rate in patients visiting a saliva clinic. Clin Oral Investig 22(9):3121–7CrossRefPubMedPubMedCentral
12.
Jager DHJ, Bots CP, Forouzanfar T, Brand HS (2018) Clinical oral dryness score: evaluation of a new screening method for oral dryness. Odontology 106(4):439–444CrossRefPubMedPubMedCentral
13.
Challacombe SJ, Osailan SM, Proctor GB (2015) Clinical scoring scales for assessment of dry mouth. In: Carpenter G (ed) Dry mouth: a clinical guide on causes, effects and treatments. Berlin, Heidelberg, Springer, Berlin Heidelberg, pp 119–132CrossRef
14.
Chaudhury NM, Proctor GB, Karlsson NG, Carpenter GH, Flowers SA (2016) Reduced mucin-7 (Muc7) sialylation and altered saliva rheology in Sjögren’s syndrome associated oral dryness. Mol Cell Proteomics 15(3):1048–1059CrossRefPubMed
15.
Chaudhury NM, Shirlaw P, Pramanik R, Carpenter GH, Proctor GB (2015) Changes in saliva rheological properties and mucin glycosylation in dry mouth. J Dent Res 94(12):1660–1667CrossRefPubMed
16.
Assy Z, Bots CP, Arisoy HZ, Gülveren SS, Bikker FJ, Brand HS (2021) Differences in perceived intra-oral dryness in various dry-mouth patients as determined using the Regional Oral Dryness Inventory. Clin Oral Invest 25(6):4031–4043CrossRef
17.
Assy Z, Jager DHJ, Mashhour E, Bikker FJ, Brand HS (2020) Regional differences in perceived oral dryness as determined with a newly developed questionnaire, the Regional Oral Dryness Inventory. Clin Oral Invest 24(11):4051–4060CrossRef
18.
Brand HS, Bots CP, Veerman ECI (2011) Therapies for xerostomia in Sjögren’s disease are age- and gender dependent. J Dent Res 90(Special Issue A):1347
19.
Donaldson M, Epstein J, Villines D (1939) (2014) Managing the care of patients with Sjögren syndrome and dry mouth: comorbidities, medication use and dental care considerations. J Am Dent Assoc 145(12):1240–1247CrossRef
20.
Purdie MJ, Carpenter MD, Noll JL et al (2023) Patient satisfaction and impact of salivary flow rate on effectiveness of xerostomia products. Oral Surg, Oral Med, Oral Pathol Oral Radiol 135(2):236–41CrossRefPubMed
21.
22.
Faruque M, Wanschers M, Ligtenberg AJ, Laine ML, Bikker FJ (2022) A review on the role of salivary MUC5B in oral health. J Oral Biosci
23.
van Nimwegen JF, Moerman RV, Sillevis Smitt N, Brouwer E, Bootsma H, Vissink A (2016) Safety of treatments for primary Sjögren’s syndrome. Expert Opin Drug Saf 15(4):513–524CrossRefPubMed
24.
Kartari A, Özen AE, Correia A, Wen J, Kozak M (2021) Impacts of COVID-19 on changing patterns of household food consumption: an intercultural study of three countries. Int J Gastron Food Sci 26:100420CrossRefPubMedPubMedCentral
25.
Mazidi M, Leeming ER, Merino J, Nguyen LH, Selvachandran S, Pujal JC, Maher T, Kadé K, Murray B, Graham MS, Sudre CH, Wolf J, Hu C, Drew DA, Steves CJ, Ourselin S, Gardner C, Spector TD, Chan AT, Franks PW, Gibson R, Berry SE (2021) Diet and lifestyle behaviour disruption related to the pandemic was varied and bidirectional among US and UK adults participating in the ZOE COVID Study. Nat Food. 2(12):957–969. https://​doi.​org/​10.​1038/​s43016-021-00398-3CrossRefPubMed
26.
Morquecho-Campos P, Bikker FJ, Nazmi K, de Graaf K, Laine ML, Boesveldt S (2019) Impact of food odors signaling specific taste qualities and macronutrient content on saliva secretion and composition. Appetite 143:104399CrossRefPubMed
27.
Vitali F, Tarperi C, Cristini J et al (2019) Action monitoring through external or internal focus of attention does not impair endurance performance. Front Psychol 10:535CrossRefPubMedPubMedCentral
28.
29.
Alves MB, Motta AC, Messina WC, Migliari DA (2004) Saliva substitute in xerostomic patients with primary Sjögren’s syndrome: a single-blind trial. Quintessence Int 35(5):392–396PubMed
30.
Brand HS, Ouzzine R, Bots CP (2013) Sticky saliva products. Br Dental J 214(3):95CrossRef
31.
Kam CCS, Zhou M (2015) Does acquiescence affect individual items consistently? Educ Psychol Meas 75(5):764–784CrossRefPubMed
Metadata
Title
Use and efficacy of dry-mouth interventions in Sjögren’s disease patients and possible association with perceived oral dryness and patients’ discomfort
Authors
Z. Assy
J. S. van Santen
H. S. Brand
F. J. Bikker
Publication date
28-07-2023
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 9/2023
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-023-05172-2

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