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Open Access 04-04-2023 | Osteitis | Review

Effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis: a scoping review

Authors: Giusy Rita Maria La Rosa, Antonia Marcianò, Carlotta Ylenia Priolo, Matteo Peditto, Eugenio Pedullà, Alberto Bianchi

Published in: Clinical Oral Investigations | Issue 7/2023

Abstract

Objectives

The aim of this scoping review was to determine the effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis.

Materials and methods

Reporting was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews. A literature search was conducted in the PubMed and Scopus databases to identify all clinical studies on the application of platelet-rich fibrin in the control of pain caused by alveolar osteitis. Data were extracted independently by two reviewers and qualitatively described.

Results

The initial search returned 81 articles, with 49 identified after duplicates removal; of these, 8 were selected according to the inclusion criteria. Three of the eight studies were randomized controlled clinical trials, and four were non-randomized clinical studies, two of which were controlled. One study was case series. In all of these studies, pain control was evaluated using the visual analog scale. Overall, the use of platelet-rich fibrin resulted effective in the control of pain determined by alveolar osteitis.

Conclusions

Within the limits of this scoping review, the application of platelet-rich fibrin in the post-extra-extraction alveolus reduced the pain associated with alveolar osteitis in almost all the included studies. Nevertheless, high-quality randomized trials with adequate sample size are warranted to draw firm conclusions.

Clinical relevance

Pain associated with alveolar osteitis causes discomfort to the patient and is challenging to be treated. Use of platelet-rich fibrin could be a promising clinical strategy for pain control in alveolar osteitis if its effectiveness will be confirmed by further high-quality studies.

Guo S, Dipietro LA (2010) Factors affecting wound healing. J Dent Res 89(3):219–229. https://doi.org/10.1177/0022034509359125CrossRefPubMedPubMedCentral

Rodrigues MT, Cardoso CL, Carvalho PS et al (2011) Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing. J Appl Oral Sci 19:260–268PubMedPubMedCentral

Hermesch CB, Hilton TJ, Biesbrock AR et al (1998) Perioperative use of 0.12% chlorhexidine gluconate for the prevention of alveolar osteitis: efficacy and risk factor analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:381–387PubMed

Eshghpour M, Rezaei NM, Nejat A (2013) Effect of menstrual cycle on frequency of alveolar osteitis in women undergoing surgical removal of mandibular third molar: a single-blind randomized clinical trial. J Oral Maxillofac Surg 71:1484–1489PubMed

Cardoso CL, Rodrigues MT, Ferreira Júnior O, Garlet GP, de Carvalho PS (2010) Clinical concepts of dry socket. J Oral Maxillofac Surg 68:1922–1932PubMed

Blum IR (2002) Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg 31:309–317PubMed

Kolokythas A, Olech E, Miloro M (2010) Alveolar osteitis: a comprehensive review of concepts and controversies. Int J Dent 2010:249073PubMedPubMedCentral

Nitzan DW (1983) On the genesis of ‘dry socket’. J Oral Maxillofac Surg 41:706–710PubMed

Supe NB, Choudhary SH, Yamyar SM et al (2018) Efficacy of Alvogyl (combination of Iodoform + Butylparaminobenzoate) and zinc oxide eugenol for dry socket. Ann Maxillofac Surg 8:193–199PubMedPubMedCentral

10.

Faizel S, Thomas S, Yuvaraj V, Prabhu S, Tripathi G (2015) Comparision between neocone, Alvogyl and zinc oxide eugenol packing for the treatment of dry socket: a double blind randomised control trial. J Maxillofac Oral Surg 14:312–320PubMed

11.

Garola F, Gilligan G, Panico R, Leonardi N, Piemonte E (2021) Clinical management of alveolar osteitis. A systematic review. Med Oral Patol Oral Cir Bucal 26:e691–e702PubMedPubMedCentral

12.

Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, Fujioka-Kobayashi M, Bishara M, Zhang Y, Wang HL, Chandad F, Nacopoulos C, Simonpieri A, Aalam AA, Felice P, Sammartino G, Ghanaati S, Hernandez MA, Choukroun J (2017) Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clin Oral Investig 21:1913–1927PubMed

13.

Rosamma Joseph V, Raghunath A, Sharma N (2012) Clinical effectiveness of autologous platelet rich fibrin in the management of infrabony periodontal defects. Singapore Dent J 33:5–12PubMed

14.

Dohan DM, Choukroun J, Diss A et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e45–e50PubMed

15.

Rozman P, Bolta Z (2007) Use of platelet growth factors in treating wounds and soft tissue injuries. Acta Dermatovenerol Alp Pannonica Adriat 16:156–165PubMed

16.

Simon D, Manuel S, Geetha V, Naik BR (2004) Potential for osseous regeneration of platelet rich plasma – a comparative study in mandibular third molar sockets. Indian J Dent Res 15:133–136PubMed

17.

Daugela P, Grimuta V, Sakavicius D, Jonaitis J, Juodzbalys G (2018) Influence of leukocyte- and platelet-rich fibrin (L-PRF) on the outcomes of impacted mandibular third molar removal surgery: a split-mouth randomized clinical trial. Quintessence Int 49:377–388PubMed

18.

Chakravarthi S (2017) Platelet rich fibrin in the management of established dry socket. J Korean Assoc Oral Maxillofac Surg 2017(43):160–165

19.

Kumar YR, Mohanty S, Verma M et al (2016) Platelet rich fibrin: the benefits. Br J Oral Maxillofac Surg 54:57–61PubMed

20.

Esfahrood ZR, Ardakani MT, Shokri M, Shokri M (2020) Effects of leukocyte-platelet-rich fibrin and advanced platelet-rich fibrin on the viability and migration of human gingival fibroblasts. J Indian Soc Periodontol 24:15–19PubMedPubMedCentral

21.

Chybicki D, Janas-Naze A (2022) Pain relief and antimicrobial activity in alveolar osteitis after platelet-rich fibrin application—a non-randomized controlled study. Appl Sci 12:1324

22.

Hussain I, Singh S, Jain H et al (2018) A prospective randomised clinical study on evaluation of platelet-rich fibrin versus zinc oxide eugenol in the management of alveolar osteitis. Oral Surg 11:41–49

23.

Tricco AC, Lillie E, Zarin W et al (2018) PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med 169:467–473PubMed

24.

Yüce E, Kömerik N (2019) Potential effects of advanced platelet rich fibrin as a wound-healing accelerator in the management of alveolar osteitis: a randomized clinical trial. Niger J Clin Pract 22:1189–1195PubMed

25.

Keshini MP, Shetty SK, Sundar S, Chandan SN, Manjula S (2020) Assessment of healing using Alvogyl and platelet rich fibrin in patients with dry socket - an evaluative study. Ann Maxillofac Surg 10:320–324PubMedPubMedCentral

26.

Rastogi S, Choudhury R, Kumar A et al (2018) Versatility of platelet rich fibrin in the management of alveolar osteitis-a clinical and prospective study. J Oral Biol Craniofac Res 8:188–193PubMed

27.

Reeshma S, Dain CP (2021) Comparison of platelet-rich fibrin with zinc oxide eugenol in the relief of pain in alveolar osteitis. Health Sci Rep 4:e354PubMedPubMedCentral

28.

Sharma A, Aggarwal N, Rastogi S, Choudhury R, Tripathi S (2017) Effectiveness of platelet-rich fibrin in the management of pain and delayed wound healing associated with established alveolar osteitis (dry socket). Eur J Dent 11:508–513PubMedPubMedCentral

29.

Xu JL, Sun L, Liu C, Sun ZH, Min X, Xia R (2015) Effect of oral contraceptive use on the incidence of dry socket in females following impacted mandibular third molar extraction: a meta-analysis. Int J Oral Maxillofac Surg 44:1160–1165PubMed

30.

Rakhshan V (2018) Common risk factors of dry socket (alveolitis osteitis) following dental extraction: a brief narrative review. J Stomatol Oral Maxillofac Surg 119:407–411PubMed

31.

Gadicherla S, Smriti K, Roy S, Pentapati KC, Rajan J, Walia A (2020) Comparison of extraction socket healing in non-diabetic, prediabetic, and type 2 diabetic patients. Clin Cosmet Investig Dent 12:291–296PubMedPubMedCentral

32.

Tarakji B, Saleh LA, Umair A, Azzeghaiby SN, Hanouneh S (2015) Systemic review of dry socket: aetiology, treatment, and prevention. J Clin Diagn Res 9:ZE10–ZE13PubMedPubMedCentral

33.

Cohen ME, Simecek JW (1995) Effects of gender-related factors on the incidence of localized alveolar osteitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79:416–422PubMed

34.

Tonetti MS, Claffey N, European Workshop in Periodontology group C (2005) Advances in the progression of periodontitis and proposal of definitions of a periodontitis case and disease progression for use in risk factor research. Group C consensus report of the 5th European Workshop in Periodontology. J Clin Periodontol 32:210–213PubMed

35.

Coukroun J, Adda F, Schoeffler C, Vervelle A (2001) Une opportunite’ en paro-implantologie. Le PRF

36.

Torres-Lagares D, Serrera-Figallo MA, Romero-Ruíz MM, Infante-Cossío P, García-Calderón M, Gutiérrez-Pérez JL (2005) Update on dry socket: a review of the literature. Med Oral Patol Oral Cir Bucal 10:81PubMed

37.

Lilly GE, Osbon DB, Rael EM, Samuels HS, Jones JC (1974) Alveolar osteitis associated with mandibular third molar extractions. J Am Dent Assoc 88:802–806PubMed

38.

Bortoluzzi MC, Manfro R, De Déa BE, Dutra TC (2010) Incidence of dry socket, alveolar infection, and postoperative pain following the extraction of erupted teeth. J Contemp Dent Pract 11:E033–EE40PubMed

39.

Faber J, Fonseca LM (2014) How sample size influences research outcomes. Dental Press J Orthod 19:27–29PubMedPubMedCentral

40.

Dohan Ehrenfest DM, Diss A, Odin G, Doglioli P, Hippolyte MP, Charrier JB (2009) In vitro effects of Choukroun’s PRF (platelet-rich fibrin) on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:341–352PubMed

41.

Chang IC, Tsai CH, Chang YC (2010) Platelet-rich fibrin modulates the expression of extracellular signal-regulated protein kinase and osteoprotegerin in human osteoblasts. J Biomed Mater Res A 95:327–332PubMed

42.

Munn Z, Peters MDJ, Stern C, Tufanaru C, McArthur A, Aromataris E (2018) Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med Res Methodol 8:143

43.

Tracey I, Mantyh PW (2007) The cerebral signature for pain perception and its modulation. Neuron 55:377–391PubMed

44.

Schatz J-P, Fiore-Donno G, Henning G (1987) Fibrinolytic alveolitis and its prevention. Int J Oral Maxillofac Surg 16:175–183PubMed

45.

Chapnick P, Diamond LH (1992) A review of dry socket: a double-blind study on the effectiveness of clindamycin in reducing the incidence of dry socket. J Can Dent Assoc 58:43–52PubMed

46.

Summers L, Matz L (1976) Extraction wound sockets. Histological changes and paste packs--a trial. Br Dent J 141:377–379PubMed

47.

Martínez-Zapata MJ, Martí-Carvajal A, Solà I et al (2009) Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review. Transfusion 49:44–56PubMed

Title: Effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis: a scoping review
Authors: Giusy Rita Maria La Rosa
Antonia Marcianò
Carlotta Ylenia Priolo
Matteo Peditto
Eugenio Pedullà
Alberto Bianchi
Publication date: 04-04-2023
Publisher: Springer Berlin Heidelberg
Keyword: Osteitis
Published in: Clinical Oral Investigations / Issue 7/2023
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05012-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis: a scoping review

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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