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Clinical Oral Investigations

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29-07-2022 | Gingival Diseases | Original Article

Impact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapy

Authors: Arife Sabancı, Basak Karasu, Halil Ibrahim Sabancı, İrfan Kuku, Omer Alperen Kırmızıgul

Published in: Clinical Oral Investigations | Issue 10/2022

Abstract

Objectives

Oral mucositis (OM) is a frequent complication of cancer treatments. Oral mucositis and periodontal disease have a common inflammatory pattern. The purpose of this study was to evaluate the OM and its association with periodontal status in patients with hematologic malignancies who undergo high-dose chemotherapy.

Materials and methods

Fifty-five patients who received high-dose chemotherapy were included in the study. Full-mouth periodontal clinical measurements including plaque index (PI), gingival index (GI), clinical attachment level (CAL), and probing depth (PD) values were recorded before the condition chemotherapy regime. OM monitoring was initiated 1 day after the chemotherapy and maintained for 20 days.

Results

Twenty-two of patients (40%) were observed oral mucositis after high-dose chemotherapy. Patients with mucositis had significantly higher GI scores than those who did not have mucositis (p < 0.05). There was a significantly moderate positive correlation between the grade of mucositis and GI scores (p < 0.05). In patients with periodontitis, the incidence of grade 1–2 mucositis was significantly higher than in the healthy group (p < 0.05). In individuals with periodontitis and gingivitis, the healing duration of mucositis was significantly longer than the healthy group (p < 0.05).

Conclusions

The results of this study showed that the severity grades of oral mucositis may increase in patients with gingival inflammation. The results also suggest that periodontal diseases may have a significant impact on the duration of oral mucositis.

Clinical relevance

The current study contributes to our understanding of the importance of oral health status in reducing the occurrence, severity, and duration of OM in hematological cancer patients treated with high-dose chemotherapy.

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Title: Impact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapy
Authors: Arife Sabancı
Basak Karasu
Halil Ibrahim Sabancı
İrfan Kuku
Omer Alperen Kırmızıgul
Publication date: 29-07-2022
Publisher: Springer Berlin Heidelberg
Keywords: Gingival Diseases
Gingiva Index
Cytostatic Therapy
Dental Plaque Index
Published in: Clinical Oral Investigations / Issue 10/2022
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-022-04588-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of periodontal status on the oral mucositis in patients receiving high-dose chemotherapy

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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