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01-02-2022 | SARS-CoV-2 | Original Article

The clinical association between Periodontitis and COVID-19

Authors: Shipra Gupta, Ritin Mohindra, Mohita Singla, Sagar Khera, Vaibhav Sahni, Poonam Kanta, Roop Kishor Soni, Amit Kumar, Krishan Gauba, Kapil Goyal, Mini P. Singh, Arnab Ghosh, Kamal Kajal, Varun Mahajan, Ashish Bhalla, Timo Sorsa, Ismo Räisänen

Published in: Clinical Oral Investigations | Issue 2/2022

Abstract

Objectives

The study aimed to clinically assess the association between periodontitis and COVID-19-related outcomes.

Material and methods

Data pertaining to patient demographics, medical history, blood parameters, periodontal clinical examination and aMMP-8 point-of-care diagnostics (both site-level and patient-level) was recorded for eighty-two COVID-19-positive patients. COVID-19-related outcomes such as COVID-19 pneumonia, death/survival, types of hospital admission and need of assisted ventilation were also assessed.

Results

Males were predominantly afflicted with COVID-19, with advanced age exhibiting a greater association with the presence of periodontitis. Higher severity of periodontitis led to 7.45 odds of requiring assisted ventilation, 36.52 odds of hospital admission, 14.58 odds of being deceased and 4.42 odds of COVID-19-related pneumonia. The aMMP-8 mouthrinse kit was slightly more sensitive but less specific than aMMP-8 site-specific tests.

Conclusions

Based on the findings of the present study, periodontitis seems to be related to poorer COVID-19-related outcomes. However, within the constraints of this work, a direct causality may not be established. Periodontitis, by means of skewing the systemic condition for a number of comorbidities, may eventually influence COVID-19 outcomes in an indirect manner.

Clinical relevance

The study is the first to clinically, and by means of a validated point-of-care diagnostic methodology, assess the association between periodontal health and COVID-19-related outcomes. Assessment of the periodontal status of individuals can aid in the identification of risk groups during the pandemic along with reinforcing the need to maintain oral hygiene and seeking periodontal care.

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Title: The clinical association between Periodontitis and COVID-19
Authors: Shipra Gupta
Ritin Mohindra
Mohita Singla
Sagar Khera
Vaibhav Sahni
Poonam Kanta
Roop Kishor Soni
Amit Kumar
Krishan Gauba
Kapil Goyal
Mini P. Singh
Arnab Ghosh
Kamal Kajal
Varun Mahajan
Ashish Bhalla
Timo Sorsa
Ismo Räisänen
Publication date: 01-02-2022
Publisher: Springer Berlin Heidelberg
Keywords: SARS-CoV-2
COVID-19
Gingival Diseases
Periodontics
Published in: Clinical Oral Investigations / Issue 2/2022
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-021-04111-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The clinical association between Periodontitis and COVID-19

Abstract

Objectives

Material and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Material and methods

Results

Conclusions

Clinical relevance

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