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Clinical Oral Investigations

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01-02-2020 | Oral Cancer | Original Article

Perinerural, lymphovascular and depths of invasion in extrapolating nodal metastasis in oral cancer

Authors: Alkananda Sahoo, Swagatika Panda, Neeta Mohanty, Debkant Jena, Niranjan Mishra, Surabhi, Manas R. Baisakh

Published in: Clinical Oral Investigations | Issue 2/2020

Abstract

Objective

The role of tumour thickness (TT), depth of invasion (DOI) from two different reference points (TT2 and TT3), perineural invasion (PNI) and lymphovascular invasion (LVI) were evaluated to predict lymph node metastasis (LNM) in oral squamous cell carcinoma (OSCC). Reference points for measuring the DOI were suggested.

Material and methods

Paraffin-embedded tissues of excisional biopsy cases diagnosed as OSCC were sectioned and stained in haematoxylin and eosin to study variables like TT1, TT2, TT3, PNI and LVI. Out of total 150 cases collected for the study, 136, 123 and 149 cases were qualified for analysis of TT1, TT2 and TT3 respectively. The association with LNM was studied using chi square test of independence. A binary logistic regression model (BLC) was developed to indicate high-risk cases.

Results

Receiver operating curve analysis suggested an optimum cut-off value. A significant correlation of TT1 (> 8.64, RR = 1.642, p = 0.018) and TT2 (> 7.64, RR = 2.041, p = 0.016), PNI (p = 0.028) and LVI (p = 0.000) were found with LNM. A mathematical model was suggested as Z = − 1.866 + 0.101TT2 + 2.106VI + e, where Z = log [(p/(1 − p)] p = probability of the case experiencing the event of interest.

Conclusion

With the suggestion of a standardised reference point to measure DOI for the first time, this study has shown an association of TT1, TT2, PNI and LVI with LNM in Indian Population. The mathematical model can help in identifying high-risk cases in OSCC.

Clinical relevance

Such studies would offer avenues for the pre-surgery assessment of depth of invasion and tumour thickness before performing neck dissection, thereby decreasing morbidity.

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Title: Perinerural, lymphovascular and depths of invasion in extrapolating nodal metastasis in oral cancer
Authors: Alkananda Sahoo
Swagatika Panda
Neeta Mohanty
Debkant Jena
Niranjan Mishra
Surabhi
Manas R. Baisakh
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Keywords: Oral Cancer
Metastasis
Neck Dissection
Oral Cavity Carcinoma
Published in: Clinical Oral Investigations / Issue 2/2020
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-019-02921-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Perinerural, lymphovascular and depths of invasion in extrapolating nodal metastasis in oral cancer

Abstract

Objective

Material and methods

Results

Conclusion

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Material and methods

Results

Conclusion

Clinical relevance

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