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Clinical Oral Investigations
Published in: Clinical Oral Investigations 1/2018

01-01-2018 | Review

Systematic review of oral manifestations related to hyperparathyroidism

Authors: Benjamin Palla, Egon Burian, Riham Fliefel, Sven Otto

Published in: Clinical Oral Investigations | Issue 1/2018

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Abstract

Objectives

We sought to identify oral symptoms found in hyperparathyroidism and compare their rate of occurrence, as well as potential variations in sequelae between primary, secondary, and tertiary hyperparathyroidism.

Materials and methods

Database searches were performed through EMBASE and PubMed, with a continual handsearch for relevant articles. PRISMA guidelines were followed.

Results

Two hundred five articles including 245 patients were analyzed with data extraction. The average age was 34.02 years old (age range 1–83), with 91 male and 154 female patients (1:1.7 M/F ratio). Patients presented with symptoms including facial asymmetry or swelling (167/214 cases; 78.0%), oral pain (30/214; 14.0%), systemic symptoms (25/214; 11.7%), referrals or incidental findings (16/214; 7.5%), and neuropathy (6/214; 2.8%) independently and in combination together. Bony pathology occurred most often in the mandible (100/245 cases; 40.8%), while 72 cases were in the maxilla (29.4%) and 73 cases in both jaw bones (29.8%).

Conclusions

Our data collection identifies a wide variation in the presentation of hyperparathyroidism. In order to be more certain of oral maladies from hyperparathyroidism, studies with large patient populations need to be conducted at healthcare centers to clarify the oral outcomes of hyperparathyroidism.

Clinical relevance

What was thought to be a characteristic finding of HPT, mandibular radiolucency occurred in only a minor portion of cases. Furthermore, the pathognomonic sign of HPT on radiograph, loss of lamina dura, was only the third most common presentation. Bone pathology was most commonly reported in literature, but should not be assumed the only oral sequelae of hyperparathyroidism.
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Metadata
Title
Systematic review of oral manifestations related to hyperparathyroidism
Authors
Benjamin Palla
Egon Burian
Riham Fliefel
Sven Otto
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 1/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-017-2124-0

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