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Clinical Oral Investigations
Published in: Clinical Oral Investigations 4/2014

01-05-2014 | Original Article

Cervical metastases of squamous cell carcinoma of the maxilla: a retrospective study of 25 years

Authors: K. Sagheb, Ka. Sagheb, K. J. Taylor, B. Al-Nawas, C. Walter

Published in: Clinical Oral Investigations | Issue 4/2014

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Abstract

Objectives

Squamous cell carcinomas (SCCs) of the maxilla are relatively rare; therefore, only little data is available regarding the frequency of cervical metastasis (CM) and therapy strategies. Most authors only undertake clinical observation of the lymph nodes. The aim of this retrospective study was to evaluate the manner of metastasis in SCC of the maxilla.

Materials and methods

All patient records from 1987 to 2011 were scanned for SCC of the maxilla. Patients with SCC limited to the maxilla were comprised. The cases were analyzed regarding tumor node metastasis staging system and any special occurrences in the follow-up time such as tumor recurrence, metastasis, and exitus letalis. Classification and staging were performed according to the 2003 UICC system.

Results

One hundred thirty-eight patients were comprised of 36 % females and 64 % males (average age, 66 years; women, 71 years; men, 63 years). The average follow-up time was 43 months (range, 0–195). Fifty-eight percent smoked or declared regular consumption of alcohol. About 50 % of the patients had an advanced tumor stage (III–IV). At the time of the primary diagnosis, 38 % of the patients had CM. There is an increased risk for CM occurrence with increasing tumor size and grading and a tumor localized in the postcanine region. Contralateral CM arises frequently in T4 tumors and tumors localized in the postcanine region.

Conclusion

The data exhibit aggressive regional metastatic behavior of SCC of the maxilla.

Clinical relevance

Therefore, surgical treatment of the draining lymphatic system as a primary management strategy is recommended for patients with SCC of the maxilla.
Literature
1.
Argiris A, Karamouzis MV, Raben D, Ferris RL (2008) Head and neck cancer. Lancet 371(9625):1695–1709PubMedCrossRef
2.
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer statistics, 2008. CA. CA: Cancer J Clin 58(2):71–96
3.
Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R (2011) Epidemiology of cancer from the oral cavity and oropharynx. Eur J Gastroenterol Hepatol 23(8):633–641PubMedCrossRef
4.
Kowalski LP, Carvalho AL (2001) Influence of time delay and clinical upstaging in the prognosis of head and neck cancer. Oral Oncol 37(1):94–98PubMedCrossRef
5.
Capote A, Escorial V, Munoz-Guerra MF, Rodriguez-Campo FJ, Gamallo C, Naval L (2007) Elective neck dissection in early-stage oral squamous cell carcinoma—does it influence recurrence and survival? Head Neck 29(1):3–11PubMedCrossRef
6.
Hiratsuka H, Miyakawa A, Nakamori K, Kido Y, Sunakawa H, Kohama G (1997) Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer 80(3):351–356PubMedCrossRef
7.
Kowalski LP, Bagietto R, Lara JR, Santos RL, Tagawa EK, Santos IR (1999) Factors influencing contralateral lymph node metastasis from oral carcinoma. Head Neck 21(2):104–110PubMedCrossRef
8.
Woolgar JA (2007) The topography of cervical lymph node metastases revisited: the histological findings in 526 sides of neck dissection from 439 previously untreated patients. Int J Oral Max Surg 36(3):219–225CrossRef
9.
Mishra P, Sharma AK (2010) A 3-year study of supraomohyoid neck dissection and modified radical neck dissection type I in oral cancer: with special reference to involvement of level IV node metastasis. Eur Arch Otorhinolaryngol 267(6):933–938PubMedCrossRef
10.
Yuen AP, Ho CM, Chow TL, Tang LC, Cheung WY, Ng RW, Wei WI, Kong CK, Book KS, Yuen WC, Lam AK, Yuen NW, Trendell-Smith NJ, Chan YW, Wong BY, Li GK, Ho AC, Ho WK, Wong SY, Yao TJ (2009) Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma. Head Neck 31(6):765–772PubMedCrossRef
11.
Chiu RJ, Myers EN, Johnson JT (2004) Efficacy of routine bilateral neck dissection in the management of supraglottic cancer. Otolaryngol Head Neck Surg 131(4):485–488PubMedCrossRef
12.
Haddadin KJ, Soutar DS, Oliver RJ, Webster MH, Robertson AG, MacDonald DG (1999) Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection. Head Neck 21(6):517–525PubMedCrossRef
13.
14.
Simental AA Jr, Johnson JT, Myers EN (2006) Cervical metastasis from squamous cell carcinoma of the maxillary alveolus and hard palate. The Laryngoscope 116(9):1682–1684PubMedCrossRef
15.
16.
Kim GE, Chung EJ, Lim JJ, Keum KC, Lee SW, Cho JH, Lee CG, Choi EC (1999) Clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary antrum. Am J Otolaryngol 20(6):383–390PubMedCrossRef
17.
Beltramini GA, Massarelli O, Demarchi M, Copelli C, Cassoni A, Valentini V, Tullio A, Gianni AB, Sesenna E, Baj A (2012) Is neck dissection needed in squamous-cell carcinoma of the maxillary gingiva, alveolus, and hard palate? A multicentre Italian study of 65 cases and literature review. Oral Oncol 48(2):97–101PubMedCrossRef
18.
Binahmed A, Nason RW, Hussain A, Abdoh AA, Sandor GK (2008) Treatment outcomes in squamous cell carcinoma of the maxillary alveolus and palate: a population-based study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105(6):750–754PubMedCrossRef
19.
Al-Rawi NH, Talabani NG (2008) Squamous cell carcinoma of the oral cavity: a case series analysis of clinical presentation and histological grading of 1,425 cases from Iraq. Clin Oral Invest 12(1):15–18CrossRef
20.
Dr. Joachim Bertz DSD, Dr. Jörg Haberland,, Dr. Klaus Kraywinkel DB-MK, Dr. Ute Wolf (2010) Verbreitung von Krebserkrankungen in Deutschland Entwicklung der Prävalenzen zwischen 1990 und 2010. Eine Veröffentlichung des Zentrums für Krebsregisterdaten am RKI, Westkreuz-Druckerei, Berlin
21.
22.
Cooper JS, Porter K, Mallin K, Hoffman HT, Weber RS, Ang KK, Gay EG, Langer CJ (2009) National cancer database report on cancer of the head and neck: 10-year update. Head Neck 31(6):748–758PubMedCrossRef
23.
Warnakulasuriya S (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45(4–5):309–316PubMedCrossRef
24.
Rasse M (2008) Surgical treatment options for squamous cell carcinoma of the oral cavity. Wien Med Wochenschr 158(9–10):243–248PubMedCrossRef
25.
Sankaranarayanan R, Masuyer E, Swaminathan R, Ferlay J, Whelan S (1998) Head and neck cancer: a global perspective on epidemiology and prognosis. Anticancer Res 18(6B):4779–4786PubMed
26.
Howaldt HP, Vorast H, Blecher JC, Reicherts M, Kainz M (2000) [Results of the DOSAK tumor register]. Mund Kiefer Gesichtschir 4 Suppl 1:S216-225
27.
Kokemuller H, Brachvogel P, Eckardt A, Hausamen JE (2002) Effectiveness of neck dissection in metastasizing mouth carcinoma. Uni- and multivariate analysis of factors of influence. Mund Kiefer Gesichtschir 6(2):91–97PubMedCrossRef
28.
Sano D, Myers JN (2007) Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metast Rev 26(3–4):645–662CrossRef
29.
Kurokawa H, Yamashita Y, Takeda S, Zhang M, Fukuyama H, Takahashi T (2002) Risk factors for late cervical lymph node metastases in patients with stage I or II carcinoma of the tongue. Head Neck 24(8):731–736PubMedCrossRef
30.
Wallwork BD, Anderson SR, Coman WB (2007) Squamous cell carcinoma of the floor of the mouth: tumour thickness and the rate of cervical metastasis. ANZ J Surg 77(9):761–764PubMedCrossRef
31.
Werner LA (2002) Lymphknotenerkrankungen im Kopf-Halsbereich Onkologie und Differenzialdiagnostik. First edn. Springer, Berlin Heidelberg New YorkCrossRef
32.
Fan S, Tang QL, Lin YJ, Chen WL, Li JS, Huang ZQ, Yang ZH, Wang YY, Zhang DM, Wang HJ, Dias-Ribeiro E, Cai Q, Wang L (2011) A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma. Int J Oral Sci 3(4):180–191PubMedCentralPubMedCrossRef
33.
Frerich B (2010) Standardtherapie von Plattenepithelkarzinomen der Mundhöhle gemäß Leitlinien. MKG-Chirurg 3:16–24CrossRef
34.
Lin HW, Bhattacharyya N (2009) Survival impact of nodal disease in hard palate and maxillary alveolus cancer. The Laryngoscope 119(2):312–315PubMedCrossRef
35.
Morris LG, Patel SG, Shah JP, Ganly I (2011) High rates of regional failure in squamous cell carcinoma of the hard palate and maxillary alveolus. Head Neck 33(6):824–830PubMedCentralPubMedCrossRef
36.
Montes DM, Carlson ER, Fernandes R, Ghali GE, Lubek J, Ord R, Bell B, Dierks E, Schmidt BL (2011) Oral maxillary squamous carcinoma: an indication for neck dissection in the clinically negative neck. Head Neck 33(11):1581–1585PubMedCrossRef
37.
Truitt TO, Gleich LL, Huntress GP, Gluckman JL (1999) Surgical management of hard palate malignancies. Otolaryngol Head Neck Surg 121(5):548–552PubMedCrossRef
38.
Mourouzis C, Pratt C, Brennan PA (2010) Squamous cell carcinoma of the maxillary gingiva, alveolus, and hard palate: is there a need for elective neck dissection? Br J Oral Maxillofac Surg 48(5):345–348PubMedCrossRef
39.
Montes DM, Schmidt BL (2008) Oral maxillary squamous cell carcinoma: management of the clinically negative neck. J Oral Maxillofac Surg 66(4):762–766PubMedCrossRef
40.
Ogura I, Kurabayashi T, Sasaki T, Amagasa T, Okada N, Kaneda T (2003) Maxillary bone invasion by gingival carcinoma as an indicator of cervical metastasis. Dento Maxillo Fac Radiol 32(5):291–294CrossRef
Metadata
Title
Cervical metastases of squamous cell carcinoma of the maxilla: a retrospective study of 25 years
Authors
K. Sagheb
Ka. Sagheb
K. J. Taylor
B. Al-Nawas
C. Walter
Publication date
01-05-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 4/2014
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-013-1070-8

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