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01-07-2014 | Original Article

The short-term effect after a single injection of high-molecular-weight hyaluronic acid in patients with enthesopathies (lateral epicondylitis, patellar tendinopathy, insertional Achilles tendinopathy, and plantar fasciitis): a preliminary study

Authors: Tsukasa Kumai, Takeshi Muneta, Akihiro Tsuchiya, Masaharu Shiraishi, Yoshitaka Ishizaki, Kazuya Sugimoto, Norihiro Samoto, Shinji Isomoto, Yasuhito Tanaka, Yoshinori Takakura

Published in: Journal of Orthopaedic Science | Issue 4/2014

Abstract

Background

Hyaluronic acid (HA) with a high molecular weight of 2700 kDa is approved in Japan to treat osteoarthritis of the knee, periarthritis scapulohumeralis, and knee pain associated with rheumatoid arthritis. The purpose of this preliminary study was to investigate the short-term efficacy, safety, and injectable volume of HA in the treatment of enthesopathies.

Methods

A total of 61 patients (16 with lateral epicondylitis, 14 with patellar tendinopathy, 15 with insertional Achilles tendinopathy, and 16 with plantar fasciitis) were each administered a single injection of HA (up to 2.5 ml). Efficacy and safety were assessed by comparing the visual analog scale (VAS) for pain and local symptoms before injection (baseline) and at 1 week after injection. We also investigated the injectable volume by means of the difference in syringe weight before and after injection and by the judgment of the administering investigator.

Results

The injection of HA resulted in a change in VAS (mean ± SD) of −2.20 ± 2.26 cm for the four sites overall and −2.55 ± 2.43 cm for lateral epicondylitis, −2.01 ± 2.16 cm for patellar tendinopathy, −1.80 ± 1.91 cm for insertional Achilles tendinopathy, and −2.38 ± 2.61 cm for plantar fasciitis. The injection of HA also improved local symptoms in each site. It was also determined that 2.5 ml of HA can be injected in each of the four sites.

Conclusion

A single injection of HA resulted in similar improvements of pain in each of the four enthesopathies (lateral epicondylitis, patellar tendinopathy, insertional Achilles tendinopathy, and plantar fasciitis). These results suggest that HA could be clinically effective in the treatment of enthesopathies.

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Title: The short-term effect after a single injection of high-molecular-weight hyaluronic acid in patients with enthesopathies (lateral epicondylitis, patellar tendinopathy, insertional Achilles tendinopathy, and plantar fasciitis): a preliminary study
Authors: Tsukasa Kumai
Takeshi Muneta
Akihiro Tsuchiya
Masaharu Shiraishi
Yoshitaka Ishizaki
Kazuya Sugimoto
Norihiro Samoto
Shinji Isomoto
Yasuhito Tanaka
Yoshinori Takakura
Publication date: 01-07-2014
Publisher: Springer Japan
Published in: Journal of Orthopaedic Science / Issue 4/2014
Print ISSN: 0949-2658
Electronic ISSN: 1436-2023
DOI: https://doi.org/10.1007/s00776-014-0579-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The short-term effect after a single injection of high-molecular-weight hyaluronic acid in patients with enthesopathies (lateral epicondylitis, patellar tendinopathy, insertional Achilles tendinopathy, and plantar fasciitis): a preliminary study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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