Top

Published in:

Open Access 01-07-2006 | Instructional lecture

Premalignant conditions of bone

Authors: Andrew Horvai, K. Krishnan Unni

Published in: Journal of Orthopaedic Science | Issue 4/2006

Excerpt

The etiology of most malignant bone tumors is poorly understood, and most bone malignancies are believed to arise de novo. Nevertheless, a small number of malignant bone tumors arise in recognizable benign precursors, and these lesions may be may be divided into three conceptual categories: diseases with documented predisposition to malignant bone tumors; sporadic benign tumors with a known risk for secondary malignancy; and postradiation malignant tumors (Table 1). The following review attempts to summarize the more common entities in each category with an emphasis on clinical manifestations and pathological findings.

Table 1

Premalignant conditions of bone

Genetic predisposition

Retinoblastoma

Rothmund Thompson syndrome

Bloom syndrome

Li-Fraumeni syndrome

Sporadic premalignant lesions

Paget’s disease

Giant cell tumor

Chronic osteomyelitis, sinus tract

Osteoblastoma

Chondroid neoplasms

Osteochondroma

Synovial chondromatosis

Enchondroma

Fibrous dysplasia

Postradiation sarcoma

…

Wang, LL, Levy, ML, Lewis, RA, Chintagumpala, MM, Lev, D, Rogers, M, et al. 2001Clinical manifestations in a cohort of 41 Rothmund-Thomson syndrome patientsAm J Med Genet102117CrossRefPubMed

Hadjipavlou, A, Lander, P, Srolovitz, H, Enker, IP 1992Malignant transformation in Paget disease of boneCancer7028028CrossRefPubMed

Greditzer, HG,3rd, McLeod, RA, Unni, KK, Beabout, JW 1983Bone sarcomas in Paget diseaseRadiology14632733PubMed

McKenna, RJ, et al. 1964Osteogenic sarcoma arising in Paget’s diseaseCancer174266CrossRefPubMed

McKenna, RJ, Schwinn, CP, Soong, KY, Higinbotham, NL 1966Sarcomate of the osteogenic series (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteogenic sarcoma, and sarcomata arising in abnormal bone): an analysis of 552 casesJ Bone Joint Surg48126

Schajowicz, FE, Santini Araujo, E, Berenstein, M 1983Sarcoma complicating Paget’s disease of bone: a clinicopathological study of 62 casesJ Bone Joint Surg Br65299307PubMed

Huvos, AG, Butler, A, Bretsky, SS 1983Osteogenic sarcoma associated with Paget’s disease of bone: a clinicopathologic study of 65 patientsCancer52148995CrossRefPubMed

Haibach, H, Farrell, C, Dittrich, FJ 1985Neoplasms arising in Paget’s disease of bone: a study of 82 casesAm J Clin Pathol83594600PubMed

Jattiot, F, Goupille, P, Azais, I, Roulot, B, Alcalay, M, Jeannou, J, et al. 1999Fourteen cases of sarcomatous degeneration in Paget’s diseaseJ Rheumatol261505PubMed

10.

Porretta, CA, Dahlin, DC, Janes, JM 1957Sarcoma in Paget’s disease of boneJ Bone Joint Surg Am39131429PubMed

11.

Bertoni, F, Bacchini, P, Staals, EL 2003Malignancy in giant cell tumor of boneCancer9725209CrossRefPubMed

12.

Hutter, RV, Worcester, JN,Jr, Francis, KC, Foote, FW,Jr, Stewart, FW 1962Benign and malignant giant cell tumors of bone: a clinicopathological analysis of the natural history of the diseaseCancer1565390CrossRefPubMed

13.

Dahlin, DC, Cupps, RE, Johnson, EW,Jr 1970Giant-cell tumor: a study of 195 casesCancer25106170CrossRefPubMed

14.

Nascimento, AG, Huvos, AG, Marcove, RC 1979Primary malignant giant cell tumor of bone: a study of eight cases and review of the literatureCancer441393402CrossRefPubMed

15.

Fechner RE, Mills SE. Tumors of the bones and joints. In: Atlas of tumor pathology. Third series, fasc. 8. Washington, DC: Armed Forces Institute of Pathology; 1993

16.

Unni, KK, Dahlin, DC 1979Premalignant tumors and conditions of boneAm J Surg Pathol34760PubMed

17.

Fitzgerald, RH,Jr, Brewer, NS, Dahlin, DC 1976Squamous-cell carcinoma complicating chronic osteomyelitisJ Bone Joint Surg Am5811468PubMed

18.

Sonin, AH, Resnik, CS, Mulligan, ME, Murphey, MD 1998General case of the day: squamous cell carcinoma arising in a chronic draining sinus tract as a complication of chronic osteomyelitisRadiographics185302PubMed

19.

McGrory, JE, Pritchard, DJ, Unni, KK, Ilstrup, D, Rowland, CM 1999Malignant lesions arising in chronic osteomyelitisClin Orthop3621819PubMed

20.

Puri, A, Parasnis, AS, Udupa, KV, Duggal, A, Agarwal, MG 2003Fibroblastic osteosarcoma arising in chronic osteomyelitisClin Radiol581702CrossRefPubMed

21.

Akbarnia, BA, Wirth, CR, Colman, N 1976Fibrosarcoma arising from chronic osteomyelitis: case report and review of the literatureJ Bone Joint Surg Am581235PubMed

22.

Campodonico, F, Carmingnani, G 2003Pelvic sarcoma arising from chronic osteomyelitisJ Clin Pathol565589CrossRefPubMed

23.

Altay, M, Arikan, M, Yildiz, Y, Sagli, KY 2004Squamous cell carcinoma arising in chronic osteomyelitis in foot and ankleFoot Ankle Int258059PubMed

24.

Lucas, DR, Unni, KK, McLeod, RA, O’Connor, MI, Sim, FH 1994Osteoblastoma: clinicopathologic study of 306 casesHum Pathol2511734CrossRefPubMed

25.

Kunze, E, Enderle, A, Radig, K, Schneider-Stock, R 1996Aggressive osteoblastoma with focal malignant transformation and development of pulmonary metastases: a case report with a review of literatureGen Diagn Pathol14137792PubMed

26.

McLeod, RA, Dahlin, D, Beabout, JW 1976The spectrum of osteoblastomaAJR Am J Roentgenol1263215PubMed

27.

Seki, T, Fukuda, H, Ishii, Y, Hanaoka, H, Yatabe, S 1975Malignant transformation of benign osteoblastoma: a case reportJ Bone Joint Surg Am574246PubMed

28.

Della Rocca, C, Huvos, AG 1996Osteoblastoma: varied histological presentations with a benign clinical course: an analysis of 55 casesAm J Surg Pathol2084150CrossRefPubMed

29.

Dorfman, HD, Weiss, SW 1984Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcomaSemin Diagn Pathol121534PubMed

30.

Bertoni, F, Unni, KK, McLeod, RA, Dahlin, DC 1985Osteosarcoma resembling osteoblastomaCancer5541626CrossRefPubMed

31.

Cheung, FM, Wu, WC, Lam, CK, Fu, YK 1997Diagnostic criteria for pseudomalignant osteoblastomaHistopathology31196200CrossRefPubMed

32.

Bertoni, F, Bacchini, P, Donati, D, Martini, A, Picci, P, Campanacci, M 1993Osteoblastoma-like osteosarcoma: the Rizzoli Institute experienceMod Pathol670716PubMed

33.

Radig, K, Schneider-Stock, R, Mittler, U, Neumann, HW, Roessner, A 1998Genetic instability in osteoblastic tumors of the skeletal systemPathol Res Pract19466977PubMed

34.

Grace, J, McCarthy, S, Stankovic, R, Marsden, W 1993Malignant transformation of osteoblastoma: study using image analysis microdensitometryJ Clin Pathol4610249CrossRefPubMed

35.

Ahn, J, Ludecke, HJ, Lindow, S, Horton, WA, Lee, B, Wagner, MJ, et al. 1995Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)Nat Genet1113743CrossRefPubMed

36.

Bovee, JV, Cleton-Jansen, AM, Wuyts, W, Caethoven, G, Taminiau, AH, Bakker, E 1999EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomasAm J Hum Genet6568998CrossRefPubMed

37.

Ahmed, AR, Tan, TS, Unni, KK, Collins, MS, Wenger, DE, Sim, FH 2003Secondary chondrosarcoma in osteochondroma: report of 107 patientsClin Orthop411193206CrossRefPubMed

38.

Jaffe, HL 1958Tumors and tumorous conditions of the bones and jointsLea & FebigerPhiladelphia

39.

Lichtenstein, L 1977Bone tumors5th ed.MosbySt. Louisxviii

40.

Dorfman, HD, Czerniak, B 1998Bone tumorsMosbySt. Louisix

41.

Unni, KK 2001Cartilaginous lesions of boneJ Orthop Sci645772CrossRefPubMed

42.

Bovee, JV, Sakkers, RJ, Geirnaerdt, MJ, Taminiau, AH, Hogendoorn, PC 2002Intermediate grade osteosarcoma and chondrosarcoma arising in an osteochondroma: a case report of a patient with hereditary multiple exostosesJ Clin Pathol552269CrossRefPubMed

43.

Anderson, RL,Jr, Popowitz, L, Li, JK 1969An unusual sarcoma arising in a solitary osteochondromaJ Bone Joint Surg Am511199204PubMed

44.

Lamovec, J, Spiler, M, Jevtic, V 1999Osteosarcoma arising in a solitary osteochondroma of the fibulaArch Pathol Lab Med1238324PubMed

45.

Peiper, M, Zornig, C 1997Chondrosarcoma of the thumb arising from a solitary enchondromaArch Orthop Trauma Surg1162468CrossRefPubMed

46.

Remagen, W, Nidecker, A, Dolanc, B 1986Case report 368: enchondroma of the tibia with extensive myxoid degeneration; recurrence with secondary and malignant transformation to highly differentiated chondrosarcomaSkeletal Radiol153303CrossRefPubMed

47.

Hopyan, S, Gokgoz, N, Poon, R, Gensure, RC, Yu, C, Cole, WG, et al. 2002A mutant PTH/PTHrP type I receptor in enchondromatosisNat Genet3030610CrossRefPubMed

48.

Schipani, E, Kruse, K, Juppner, H 1995A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasiaScience26898100CrossRefPubMed

49.

Liu, J, Hudkins, PG, Swee, RG, Unni, KK 1987Bone sarcomas associated with Ollier’s diseaseCancer59137685CrossRefPubMed

50.

Vigorita, VJ, Ghelman, B 1999Orthopaedic pathologyLippincott Williams & WilkinsPhiladelphiaxiii

51.

Fanbury, JC, Meis-Kindblom, JM, Rosenberg, AE 1995Multiple enchondromas associated with spindle-cell hemangioendotheliomas: an overlooked variant of Maffucci’s syndromeAm J Surg Pathol19102938

52.

Lewis, RJ, Ketcham, AS 1973Maffucci’s syndrome: functional and neoplastic significance: case report and review of the literatureJ Bone Joint Surg Am55146579PubMed

53.

Hermann, G, Klein, MJ, Abdelwahab, IF, Kenan, S 1997Synovial chondrosarcoma arising in synovial chondromatosis of the right hipSkeletal Radiol263669CrossRefPubMed

54.

Kenan, S, Abdelwahab, IF, Klein, MJ, Lewis, MM 1993Case report 817: synovial chondrosarcoma secondary to synovial chondromatosisSkeletal Radiol226236PubMed

55.

Goldman, RL, Lichtenstein, L 1964Synovial chondrosarcomaCancer17123340CrossRefPubMed

56.

Villacin, AB, Brigham, LN, Bullough, PG 1979Primary and secondary synovial chondrometaplasia: histopathologic and clinicoradiologic differencesHum Pathol1043951CrossRefPubMed

57.

Davis, RI, Hamilton, A, Biggart, JD 1998Primary synovial chondromatosis: a clinicopathologic review and assessment of malignant potentialHum Pathol296838CrossRefPubMed

58.

Bertoni, F, Unni, KK, Beabout, JW, Sim, FH 1991Chondrosarcomas of the synoviumCancer6715562CrossRefPubMed

59.

Yabut, SM,Jr, Kenan, S, Sissons, HA, Lewis, MM 1988Malignant transformation of fibrous dysplasia: a case report and review of the literatureClin Orthop2282819PubMed

60.

Ruggieri, P, Sim, FH, Bond, JR, Unni, KK 1994Malignancies in fibrous dysplasiaCancer73141124CrossRefPubMed

61.

Schwartz, DT, Alpert, M 1964The malignant transformation of fibrous dysplasiaAm J Med Sci247120CrossRefPubMed

62.

Huvos, AG, Higinbotham, NL, Miller, TR 1972Bone sarcomas arising in fibrous dysplasiaJ Bone Joint Surg Am54104756PubMed

63.

Bertoni, F, Bacchini, P, Fabbri, N, Mercuri, M, Picci, P, Ruggieri, P, et al. 1993Osteosarcoma: low-grade intraosseous-type osteosarcoma, histologically resembling parosteal osteosarcoma, fibrous dysplasia, and desmoplastic fibromaCancer7133845CrossRefPubMed

64.

Kurt, AM, Unni, KK, McLeod, RA, Pritchard, DJ 1990Low-grade intraosseous osteosarcomaCancer65141828CrossRefPubMed

65.

Bertoni, F, Fernando Arias, L, Alberghini, M, Bacchini, P 2004Fibrous dysplasia with degenerative atypia: a benign lesion potentially mistaken for sarcomaArch Pathol Lab Med1287946PubMed

66.

Cahan, WG, Woodard, HQ, Higinbotham, NL, Stewart, FW, Coley, BL 1998Sarcoma arising in irradiated bone: report of eleven cases. 1948Cancer82834CrossRefPubMed

67.

Amendola, BE, Amendola, MA, McClatchey, KD, Miller, CH,Jr 1989Radiation-associated sarcoma: a review of 23 patients with postradiation sarcoma over a 50-year periodAm J Clin Oncol124115PubMedCrossRef

68.

Arlen, M, Higinbotham, NL, Huvos, AG, Marcove, RC, Miller, T, Shah, IC 1971Radiation-induced sarcoma of boneCancer28108799CrossRefPubMed

69.

Tountas, AA, Fornasier, VL, Harwood, AR, Leung, PM 1979Postirradiation sarcoma of bone: a perspectiveCancer431827CrossRefPubMed

70.

Sabanas, AO, Dahlin, DC, Childs, DS,Jr, Ivins, JC 1956Postradiation sarcoma of boneCancer952842CrossRefPubMed

71.

Sim, FH, Cupps, RE, Dahlin, DC, Ivins, JC 1972Postradiation sarcoma of boneJ Bone Joint Surg Am54147989PubMed

72.

Weatherby, RP, Dahlin, DC, Ivins, JC 1981Postradiation sarcoma of bone: review of 78 Mayo Clinic casesMayo Clin Proc56294306PubMed

73.

Lavey, RS, Eby, NL, Prosnitz, LR 1990Impact of radiation therapy and/or chemotherapy on the risk for a second malignancy after breast cancerCancer6687481CrossRefPubMed

74.

Arbabi, L, Warhol, MJ 1982Pleomorphic liposarcoma following radiotherapy for breast carcinomaCancer4987880CrossRefPubMed

75.

Doherty, MA, Rodger, A, Langlands, AO 1986Sarcoma of bone following therapeutic irradiation for breast carcinomaInt J Radiat Oncol Biol Phys121036PubMed

76.

Ferguson, DJ, Sutton, HG,Jr, Dawson, PJ 1984Late effects of adjuvant radiotherapy for breast cancerCancer54231923CrossRefPubMed

77.

Hatfield, PM, Schulz, MD 1970Postirradiation sarcoma: including 5 cases after X-ray therapy of breast carcinomaRadiology96593602PubMed

78.

Strong, LC, Herson, J, Osborne, BM, Sutow, WW 1979Risk of radiation-related subsequent malignant tumors in survivors of Ewing’s sarcomaJ Natl Cancer Inst6214016PubMed

79.

Mark, RJ, Poen, J, Tran, LM, Fu, YS, Selch, MT, Parker, RG 1994Postirradiation sarcomas: a single-institution study and review of the literatureCancer73265362CrossRefPubMed

80.

Tucker, MA, D’Angio, GL, Boice, JD,Jr, Strong, LC, Li, FP, Stovall, M, et al. 1987Bone sarcomas linked to radiotherapy and chemotherapy in childrenN Engl J Med31758893PubMedCrossRef

81.

Smith, LM, Cox, RS, Donaldson, SS 1992Second cancers in long-term survivors of Ewing’s sarcomaClin Orthop27427581PubMed

82.

Greene, MH, Glaubiger, DL, Mead, GD, Fraumeni, JF,Jr 1979Subsequent cancer in patients with Ewing’s sarcomaCancer Treat Rep6320436PubMed

83.

Thomas, PR, Perez, CA, Neff, JR, Nesbit, ME, Evans, RG 1984The management of Ewing’s sarcoma: role of radiotherapy in local tumor controlCancer Treat Rep6870310PubMed

84.

Inoue, YZ, Frassica, FJ, Sim, FH, Unni, KK, Peterson, IA, McLeod, RA 2000Clinicopathologic features and treatment of postirradiation sarcoma of bone and soft tissueJ Surg Oncol754250CrossRefPubMed

85.

Wiklund, TA, Blomqvist, CP, Raty, J, Elomaa, I, Rissanen, P, Miettinen, M 1991Postirradiation sarcoma: analysis of a nationwide cancer registry materialCancer6852431CrossRefPubMed

86.

Huvos, AG, Woodard, HQ, Cahan, WG, Higinbotham, NL, Stewart, FW, Butler, A, et al. 1985Postradiation osteogenic sarcoma of bone and soft tissues: a clinicopathologic study of 66 patientsCancer55124455CrossRefPubMed

87.

Kirova, YM, Vilcoq, JR, Asselain, B, Saste-Garau, X, Fourquet, A 2005Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution reviewCancer10485663CrossRefPubMed

88.

Taghian, A, de Vathaire, F, Terrier, P, Le, M, Auquier, A, Mouriesse, H, et al. 1991Long-term risk of sarcoma following radiation treatment for breast cancerInt J Radiat Oncol Biol Phys213617PubMed

89.

Bechler, JR, Robertson, WW,Jr, Meadows, AT, Womer, RB 1992Osteosarcoma as a second malignant neoplasm in childrenJ Bone Joint Surg Am74107983PubMed

90.

Robinson, E, Bar-Deroma, R, Rennert, G, Neugut, AI 1992A comparison of the clinical characteristics of second primary and single primary sarcoma: a population based studyJ Surg Oncol502636CrossRefPubMed

Title: Premalignant conditions of bone
Authors: Andrew Horvai
K. Krishnan Unni
Publication date: 01-07-2006
Publisher: Springer-Verlag
Published in: Journal of Orthopaedic Science / Issue 4/2006
Print ISSN: 0949-2658
Electronic ISSN: 1436-2023
DOI: https://doi.org/10.1007/s00776-006-1037-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Premalignant conditions of bone

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 4/2006

A simple method to determine the pelvic inclination angle based on anteroposterior radiographs

Distraction osteogenesis of a fresh fracture site using an external fixator

Salvage surgery for persistent femoral nonunion after total knee arthroplasty using a megaprosthesis

Preparing a version of the Nottingham Adjustment Scale (for psychological adjustment) tailored to osteoarthritis of the hip

Epidural neuroplasty versus physiotherapy to relieve pain in patients with sciatica: a prospective randomized blinded clinical trial

Purple glove syndrome associated with intravenous phenytoin administration in a patient with severe mental and motor retardation