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Archives of Virology
Published in: Archives of Virology 6/2023

01-06-2023 | Diarrhea | Original Article

Increase in rotavirus prevalence with the emergence of genotype G9P[8] in replacement of genotype G12P[6] in Sabah, Malaysia

Authors: Lia Natasha Amit, Jecelyn Leaslie John, Daisuke Mori, Abraham Zefong Chin, Andau Konodan Mosiun, Kamruddin Ahmed

Published in: Archives of Virology | Issue 6/2023

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Abstract

Rotaviruses are major causative agents of acute diarrhea in children under 5 years of age in Malaysia. However, a rotavirus vaccine has not been included in the national vaccination program. To date, only two studies have been carried out in the state of Sabah, Malaysia, although children in this state are at risk of diarrheal diseases. Previous studies showed that 16%–17% of cases of diarrhea were caused by rotaviruses and that equine-like G3 rotavirus strains are predominant. Because the prevalence of rotaviruses and their genotype distribution vary over time, this study was conducted at four government healthcare facilities from September 2019 through February 2020. Our study revealed that the proportion of rotavirus diarrhea increased significantly to 37.2% (51/137) after the emergence of the G9P[8] genotype in replacement of the G12P[8] genotype. Although equine-like G3P[8] strains remain the predominant rotaviruses circulating among children, the Sabahan G9P[8] strain belonged to lineage VI and was phylogenetically related to strains from other countries. A comparison of the Sabahan G9 strains with the G9 vaccine strains used in the RotaSiil and Rotavac vaccines revealed several mismatches in neutralizing epitopes, indicating that these vaccines might not be effective in Sabahan children. However, a vaccine trial may be necessary to understand the precise effects of vaccination.
Literature
1.
Lestari FB, Vongpunsawad S, Wanlapakorn N, Poovorawan Y (2020) Rotavirus infection in children in Southeast Asia 2008–2018: disease burden, genotype distribution, seasonality, and vaccination. J Biomed Sci 27(1):66PubMedPubMedCentralCrossRef
2.
Troeger C, Khalil IA, Rao PC, Cao S, Blacker BF, Ahmed T et al (2018) Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatr 172(10):958–965PubMedPubMedCentralCrossRef
3.
4.
Burnett E, Parashar UD, Tate JE (2021) Rotavirus infection, illness, and vaccine performance in malnourished children: a review of the literature. Pediatr Infect Dis J 40(10):930–936PubMedPubMedCentralCrossRef
5.
Varghese T, Kang G, Steele AD (2022) Understanding rotavirus vaccine efficacy and effectiveness in countries with high child mortality. Vaccines (Basel) 10(3):346PubMedCrossRef
6.
Lee WS, Lim BT, Chai PF, Kirkwood CD, Lee JK (2012) Rotavirus genotypes in Malaysia and universal rotavirus vaccination. Hum Vaccin Immunother 8(10):1401–1406PubMedPubMedCentralCrossRef
7.
Hsu VP, Abdul Rahman HB, Wong SL, Ibrahim LH, Yusoff AF, Chan LG et al (2005) Estimates of the burden of rotavirus disease in Malaysia. J Infect Dis 192(Suppl 1):S80–S86PubMedCrossRef
8.
Goh CT, Cheah PK, Soo TL, Lee WS (2009) The epidemiology and burden of childhood rotavirus infection in a tertiary hospital in Sabah, Malaysia. Med J Malaysia 64(2):146–149PubMed
9.
Amit LN, Mori D, John JL, Chin AZ, Mosiun AK, Jeffree MS et al (2021) Emergence of equine-like G3 strains as the dominant rotavirus among children under five with diarrhea in Sabah, Malaysia during 2018–2019. PLoS ONE 16(7):e0254784PubMedPubMedCentralCrossRef
10.
11.
Yahiro T, Takaki M, Chandrasena TGAN, Rajindrajith S, Iha H, Ahmed K (2018) Human-porcine reassortant rotavirus generated by multiple reassortment events in a Sri Lankan child with diarrhea. Infect Genet Evol 65:170–186PubMedCrossRef
12.
Luchs A, TimenetskyMdo C (2016) Group A rotavirus gastroenteritis: post-vaccine era, genotypes and zoonotic transmission. Einstein (Sao Paulo) 14(2):278–287PubMedCrossRef
13.
Skansberg A, Sauer M, Tan M, Santosham M, Jennings MC (2021) Product review of the rotavirus vaccines ROTASIIL, ROTAVAC, and Rotavin-M1. Hum Vaccin Immunother 17(4):1223–1234PubMedCrossRef
14.
Mitui MT, Chandrasena TN, Chan PK, Rajindrajith S, Nelson EA, Leung TF et al (2012) Inaccurate identification of rotavirus genotype G9 as genotype G3 strains due to primer mismatch. Virol J 9:144PubMedPubMedCentralCrossRef
15.
Gouvea V, Glass RI, Woods P, Taniguchi K, Clark HF, Forrester B et al (1990) Polymerase chain reaction amplification and typing of rotavirus nucleic acid from stool specimens. J Clin Microbiol 28(2):276–282PubMedPubMedCentralCrossRef
16.
Gentsch JR, Glass RI, Woods P, Gouvea V, Gorziglia M, Flores J et al (1992) Identification of group A rotavirus gene 4 types by polymerase chain reaction. J Clin Microbiol 30(6):1365–1373PubMedPubMedCentralCrossRef
17.
Gunasena S, Nakagomi O, Isegawa Y, Kaga E, Nakagomi T, Steele AD et al (1993) Relative frequency of VP4 gene alleles among human rotaviruses recovered over a 10-year period (1982–1991) from Japanese children with diarrhea. J Clin Microbiol 31(8):2195–2197PubMedPubMedCentralCrossRef
18.
Reju S, Srikanth P, Selvarajan S, Thomas RK, Barani R, Amboiram P et al (2022) A shift in circulating rotaviral genotypes among hospitalized neonates. Sci Rep 12(1):2842PubMedPubMedCentralCrossRef
19.
Kumar S, Stecher G, Li M, Knyaz C, Tamura K (2018) MEGA X: molecular evolutionary genetics analysis across computing platforms. Mol Biol Evol 35(6):1547–1549PubMedPubMedCentralCrossRef
20.
21.
22.
Mladenova Z, Korsun N, Geonova T, Iturriza-Gómara M, Rotavirus Study Group (2010) Molecular epidemiology of rotaviruses in Bulgaria: annual shift of the predominant genotype. Eur J Clin Microbiol Infect Dis 29(5):555–562PubMedCrossRef
23.
Manjate F, João ED, Chirinda P, Garrine M, Vubil D, Nobela N et al (2022) Molecular epidemiology of rotavirus strains in symptomatic and asymptomatic children in Manhiça district, Southern Mozambique 2008–2019. Viruses 14(1):134PubMedPubMedCentralCrossRef
24.
Okitsu S, Khamrin P, Hikita T, Thongprachum A, Pham NTK, Hoque SA et al (2022) Changing distribution of rotavirus A genotypes circulating in Japanese children with acute gastroenteritis in outpatient clinic, 2014–2020. J Infect Public Health 15(7):816–825PubMedCrossRef
25.
Lu L, Zhong H, Jia R, Su L, Xu M, Cao L et al (2022) Prevalence and genotypes distribution of group A rotavirus among outpatient children under 5 years with acute diarrhea in Shanghai, China, 2012–2018. BMC Gastroenterol 22(1):217PubMedPubMedCentralCrossRef
26.
Esona MD, Gautam R, Katz E, Jaime J, Ward ML, Wikswo ME et al (2021) Comparative genomic analysis of genogroup 1 and genogroup 2 rotaviruses circulating in seven US cities, 2014–2016. Virus Evol 7(1):veab023PubMedPubMedCentralCrossRef
27.
Nirwati H, Hakim MS, Aminah S, Dwija IBNP, Pan Q, Aman AT (2017) Identification of rotavirus strains causing diarrhoea in children under five years of age in Yogyakarta, Indonesia. Malays J Med Sci 24(2):68–77PubMedPubMedCentral
28.
Zaraket R, Salami A, Bahmad M, El Roz A, Khalaf B, Ghssein G et al (2020) Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis. Heliyon 6(6):e04248PubMedPubMedCentralCrossRef
29.
Tian Y, Chughtai AA, Gao Z, Yan H, Chen Y, Liu B et al (2018) Prevalence and genotypes of group A rotavirus among outpatient children under five years old with diarrhea in Beijing, China, 2011–2016. BMC Infect Dis 18(1):497PubMedPubMedCentralCrossRef
30.
Nordgren J, Bonkoungou IJ, Nitiema LW, Sharma S, Ouermi D, Simpore J et al (2012) Rotavirus in diarrheal children in rural Burkina Faso: high prevalence of genotype G6P[6]. Infect Genet Evol 12(8):1892–1898PubMedCrossRef
31.
Cubitt WD, Steele AD, Iturriza M (2000) Characterisation of rotaviruses from children treated at a London hospital during 1996: emergence of strains G9P2A[6] and G3P2A[6]. J Med Virol 61(1):150–154PubMedCrossRef
32.
Wahyuni RM, Utsumi T, Dinana Z, Yamani LN, Juniastuti WIS et al (2021) Prevalence and distribution of rotavirus genotypes among children with acute gastroenteritis in areas other than Java Island, Indonesia, 2016–2018. Front Microbiol 12:672837PubMedPubMedCentralCrossRef
33.
Dong S, Huang D, Wang Z, Zhang G, Zhang F, Sai L (2021) Clinical and molecular epidemiological characterization of rotavirus infections in children under five years old in Shandong province, China. Arch Virol 166(9):2479–2486PubMedCrossRef
34.
Degiuseppe JI, Stupka JA, Argentinean Rotavirus Surveillance Network (2021) Emergence of unusual rotavirus G9P[4] and G8P[8] strains during post vaccination surveillance in Argentina, 2017–2018. Infect Genet Evol 93:104940PubMedCrossRef
35.
Clark HF, Hoshino Y, Bell LM, Groff J, Hess G, Bachman P et al (1987) Rotavirus isolate WI61 representing a presumptive new human serotype. J Clin Microbiol 25:1757–1762PubMedPubMedCentralCrossRef
36.
Wu FT, Bányai K, Jiang B, Liu LT, Marton S, Huang YC et al (2017) Novel G9 rotavirus strains co-circulate in children and pigs, Taiwan. Sci Rep 7:40731PubMedPubMedCentralCrossRef
37.
Bozdayi G, Altay A, Yahiro T, Ahmed S, Meral M, Dogan B et al (2016) Re-emergence of genotype G9 during a five-and-a-half-year period in Turkish children with rotavirus diarrhea. Arch Virol 161(10):2879–2884PubMedCrossRef
38.
Sashina TA, Morozova OV, Epifanova NV, Novikova NA (2017) Predominance of new G9P[8] rotaviruses closely related to Turkish strains in Nizhny Novgorod (Russia). Arch Virol 162(8):2387–2392PubMedCrossRef
39.
Kaplon J, Grangier N, Pillet S, Minoui-Tran A, Vabret A, Wilhelm N et al (2018) Predominance of G9P[8] rotavirus strains throughout France, 2014–2017. Clin Microbiol Infect 24(6):660.e1-660.e4PubMedCrossRef
40.
Zuridah H, Kirkwood CD, Bishop RF, Bogdanovic-Sakran N, Yap KL (2009) Molecular characterization and epidemiology of rotavirus isolates obtained from children with diarrhoea in Malaysia. Med J Malaysia 64(3):193–196PubMed
41.
Hung LC, Wong SL, Chan LG, Rosli R, Ng AN, Bresee JS (2006) Epidemiology and strain characterization of rotavirus diarrhea in Malaysia. Int J Infect Dis 10(6):470–474PubMedCrossRef
42.
Sum MS, Perera D, Ramji N, Elie F, Cardosa MJ (2008) Molecular characterization of rotavirus A associated with outbreaks of acute gastroenteritis in Sarawak in 2001 and 2007. Int J Infect Dis 12(1):e91–e92CrossRef
43.
Phan TG, Okitsu S, Maneekarn N, Ushijima H (2007) Genetic heterogeneity, evolution and recombination in emerging G9 rotaviruses. Infect Genet Evol 7(5):656–663PubMedCrossRef
44.
Fujii Y, Oda M, Somura Y, Shinkai T (2020) Molecular characteristics of novel mono-reassortant G9P[8] rotavirus A strains possessing the NSP4 gene of the E2 genotype detected in Tokyo, Japan. Jpn J Infect Dis 73(1):26–35PubMedCrossRef
45.
Hoa-Tran TN, Nakagomi T, Vu HM, Nguyen TTT, Takemura T, Hasebe F et al (2020) Detection of three independently-generated DS-1-like G9P[8] reassortant rotavirus A strains during the G9P[8] dominance in Vietnam, 2016–2018. Infect Genet Evol 80:104194PubMedCrossRef
46.
Zhou X, Wang YH, Pang BB, Chen N, Kobayashi N (2020) Surveillance of human rotavirus in Wuhan, China (2011–2019): predominance of G9P[8] and emergence of G12. Pathogens 9(10):810PubMedPubMedCentralCrossRef
47.
Teodoroff TA, Tsunemitsu H, Okamoto K, Katsuda K, Kohmoto M, Kawashima K et al (2005) Predominance of porcine rotavirus G9 in Japanese piglets with diarrhea: close relationship of their VP7 genes with those of recent human G9 strains. J Clin Microbiol 43(3):1377–1384PubMedPubMedCentralCrossRef
48.
Gupta S, Tiku VR, Gauhar M, Khatoon K, Ray P (2021) Genetic diversity of G9 rotavirus strains circulating among diarrheic children in North India: a comparison with 116E rotavirus vaccine strain. Vaccine 39:646–651PubMedCrossRef
49.
Dyall-Smith ML, Lazdins I, Tregear GW, Holmes IH (1986) Location of the major antigenic sites involved in rotavirus serotype-specific neutralization. Proc Natl Acad Sci USA 83(10):3465–3468PubMedPubMedCentralCrossRef
50.
51.
Patel M, Shane AL, Parashar UD, Jiang B, Gentsch JR, Glass RI (2009) Oral rotavirus vaccines: how well will they work where they are needed most? J Infect Dis 200 Suppl 1(01):S39-48PubMedCrossRef
52.
Fukuda Y, Tsugawa T, Nagaoka Y, Ishii A, Nawa T, Togashi A et al (2021) Surveillance in hospitalized children with infectious diseases in Japan: pre- and post-coronavirus disease 2019. J Infect Chemother 27(11):1639–1647PubMedPubMedCentralCrossRef
53.
Ullrich A, Schranz M, Rexroth U, Hamouda O, Schaade L, Diercke M et al (2021) Impact of the COVID-19 pandemic and associated non-pharmaceutical interventions on other notifiable infectious diseases in Germany: an analysis of national surveillance data during week 1–2016—week 32–2020. Lancet Reg Health Eur 6:100103PubMedPubMedCentralCrossRef
54.
Ahn SY, Park JY, Lim IS, Chae SA, Yun SW, Lee NM et al (2021) Changes in the occurrence of gastrointestinal infections after COVID-19 in Korea. J Korean Med Sci 36(24):e180PubMedPubMedCentralCrossRef
Metadata
Title
Increase in rotavirus prevalence with the emergence of genotype G9P[8] in replacement of genotype G12P[6] in Sabah, Malaysia
Authors
Lia Natasha Amit
Jecelyn Leaslie John
Daisuke Mori
Abraham Zefong Chin
Andau Konodan Mosiun
Kamruddin Ahmed
Publication date
01-06-2023
Publisher
Springer Vienna
Keywords
Diarrhea
Diarrhea
Published in
Archives of Virology / Issue 6/2023
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-023-05803-9

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