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01-10-2015 | Brief Report

Human norovirus genogroup II recombinants in Thailand, 2009–2014

Authors: Tikumporn Phumpholsup, Thaweesak Chieochansin, Sompong Vongpunsawad, Viboonsuk Vuthitanachot, Sunchai Payungporn, Yong Poovorawan

Published in: Archives of Virology | Issue 10/2015

Abstract

Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis worldwide. New strains emerge partly due to viral recombination. In Thailand, there is a lack of data on NoV recombinants among clinical isolates. We screened stool samples from pediatric diarrheal patients for norovirus by RT-PCR and found GII.4 to be the most prevalent genotype. Phylogenetic and SimPlot analyses detected seven intra-genogroup recombinant strains: three GII.21/GII.3, two GII.12/GII.3, and two GII.12/GII.1 recombinants. Maximum chi-square analysis indicated that all had similar breakpoints near the ORF1/ORF2 junction (p < 0.001), either slightly upstream within the C-terminus of RdRp or downstream within the N-terminal domain of VP1.

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Title: Human norovirus genogroup II recombinants in Thailand, 2009–2014
Authors: Tikumporn Phumpholsup
Thaweesak Chieochansin
Sompong Vongpunsawad
Viboonsuk Vuthitanachot
Sunchai Payungporn
Yong Poovorawan
Publication date: 01-10-2015
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 10/2015
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-015-2545-5

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