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01-01-2012 | Brief Report

Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin

Authors: Andrey A. Kolokoltsov, Shramika Adhikary, Jennifer Garver, Lela Johnson, Robert A. Davey, Eric M. Vela

Published in: Archives of Virology | Issue 1/2012

Abstract

Arenaviruses and filoviruses are capable of causing hemorrhagic fever syndrome in humans. Limited therapeutic and/or prophylactic options are available for humans suffering from viral hemorrhagic fever. In this report, we demonstrate that pre-treatment of host cells with the kinase inhibitors genistein and tyrphostin AG1478 leads to inhibition of infection or transduction in cells infected with Ebola virus, Marburg virus, and Lassa virus. In all, the results demonstrate that a kinase inhibitor cocktail consisting of genistein and tyrphostin AG1478 is a broad-spectrum antiviral that may be used as a therapeutic or prophylactic against arenavirus and filovirus hemorrhagic fever.

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Title: Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin
Authors: Andrey A. Kolokoltsov
Shramika Adhikary
Jennifer Garver
Lela Johnson
Robert A. Davey
Eric M. Vela
Publication date: 01-01-2012
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 1/2012
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-011-1115-8

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