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01-06-2008 | Original Article

Genetic characterization of H1N1, H1N2 and H3N2 swine influenza virus in Thailand

Authors: Salin Chutinimitkul, Nattakarn Thippamom, Sudarat Damrongwatanapokin, Sunchai Payungporn, Roongroje Thanawongnuwech, Alongkorn Amonsin, Pitirat Boonsuk, Donruethai Sreta, Napawan Bunpong, Rachod Tantilertcharoen, Pornchai Chamnanpood, Sujira Parchariyanon, Apiradee Theamboonlers, Yong Poovorawan

Published in: Archives of Virology | Issue 6/2008

Abstract

Swine have been known to be a suitable host for influenza A virus. In Thailand, phylogenetic analysis on swine influenza virus (SIV) has as yet not been attempted. The present report presents molecular and phylogenetic analysis performed on SIV in Thailand. In this study, 12 SIV isolates from the central and eastern part of Thailand were subtyped and the molecular genetics of hemagglutinin and neuraminidase were elucidated. Three subtypes, H1N1, H1N2 and H3N2, are described. Phylogenetic analysis of the SIV hemagglutinin and neuraminidase genes shows individual clusters with swine, human or avian influenza virus at various global locations. Furthermore, amino acid substitutions were detected either at the receptor binding site or the antigenic sites of the hemagglutinin gene.

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Title: Genetic characterization of H1N1, H1N2 and H3N2 swine influenza virus in Thailand
Authors: Salin Chutinimitkul
Nattakarn Thippamom
Sudarat Damrongwatanapokin
Sunchai Payungporn
Roongroje Thanawongnuwech
Alongkorn Amonsin
Pitirat Boonsuk
Donruethai Sreta
Napawan Bunpong
Rachod Tantilertcharoen
Pornchai Chamnanpood
Sujira Parchariyanon
Apiradee Theamboonlers
Yong Poovorawan
Publication date: 01-06-2008
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 6/2008
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-008-0097-7

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