Skip to main content
Top
Published in: Journal of Neural Transmission 1/2017

Open Access 01-02-2017 | Psychiatry and Preclinical Psychiatric Studies - Review Article

Cognitive deficits in adults with obstructive sleep apnea compared to children and adolescents

Authors: Krzysztof Krysta, Agnieszka Bratek, Karolina Zawada, Radosław Stepańczak

Published in: Journal of Neural Transmission | Special Issue 1/2017

Login to get access

Abstract

Obstructive sleep apnea (OSA) can negatively affect the patient’s physical and psychological functioning, as well as their quality of life. A major consequence of OSA is impaired cognitive functioning. Indeed, several studies have shown that OSA mainly leads to deficits in executive functions, attention, and memory. As OSA can present in all age groups, these associated cognitive deficits have been observed in adults, as well as in children and adolescents. However, these cognitive deficits may have a different clinical picture in young patients compared to adults. In this review, we analyze the most affected cognitive domains in adults and children/adolescents with OSA, as evaluated by neuropsychological and neuroimaging studies. We found that deficits in working memory, attention, or executive functions cognitive domains are found in both adults and children with OSA. However, children with OSA also show changes in behavior and phonological processing necessary for proper development. Moreover, we examine the possible OSA treatments in children and adults that can have a positive influence on cognition, and therefore, improve patients’ general functioning and quality of life.
Literature
go back to reference Alchanatis M, Deligiorgis N, Zias N, Amfilochiou A, Gotsis E, Karakatsani A, Papadimitriouz A (2004) Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study. Eur Respir J 24:980–986CrossRefPubMed Alchanatis M, Deligiorgis N, Zias N, Amfilochiou A, Gotsis E, Karakatsani A, Papadimitriouz A (2004) Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study. Eur Respir J 24:980–986CrossRefPubMed
go back to reference Aloia MS, Ilniczky N, Di Dio P, Perlis ML, Greenblatt DW, Giles DE (2003) Neuropsychological changes and treatment compliance in older adults with sleep apnea. J Psychosom Res 54:71–76CrossRefPubMed Aloia MS, Ilniczky N, Di Dio P, Perlis ML, Greenblatt DW, Giles DE (2003) Neuropsychological changes and treatment compliance in older adults with sleep apnea. J Psychosom Res 54:71–76CrossRefPubMed
go back to reference Aloia MS, Arnedt JT, Davis JD, Riggs RL, Byrd D (2004) Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review. J Int Neuropsychol Soc 105:772–785 Aloia MS, Arnedt JT, Davis JD, Riggs RL, Byrd D (2004) Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review. J Int Neuropsychol Soc 105:772–785
go back to reference Antonelli Incalzi R, Marra C, Salvigni BL, Petrone A, Gemma A, Selvaggio D, Mormile F (2004) Does cognitive dysfunction conform to a distinctive pattern in obstructive sleep apnea syndrome? J Sleep Res 13:79–86CrossRefPubMed Antonelli Incalzi R, Marra C, Salvigni BL, Petrone A, Gemma A, Selvaggio D, Mormile F (2004) Does cognitive dysfunction conform to a distinctive pattern in obstructive sleep apnea syndrome? J Sleep Res 13:79–86CrossRefPubMed
go back to reference Archbold KH, Giordani B, Ruzicka DL, Chervin RD (2004) Cognitive executive dysfunction in children with mild sleep-disordered breathing. Biol Res Nurs 5:168–176CrossRefPubMed Archbold KH, Giordani B, Ruzicka DL, Chervin RD (2004) Cognitive executive dysfunction in children with mild sleep-disordered breathing. Biol Res Nurs 5:168–176CrossRefPubMed
go back to reference Atanasov AT, Dimov PD (2003) Nasal and sleep cycle—possible synchronization during night sleep. Med Hypotheses 61:275–277CrossRefPubMed Atanasov AT, Dimov PD (2003) Nasal and sleep cycle—possible synchronization during night sleep. Med Hypotheses 61:275–277CrossRefPubMed
go back to reference Barnes ME, Gozal D, Molfese DL (2012) Attention in children with obstructive sleep apnoea: an event-related potentials study. Sleep Med 13:368–377CrossRefPubMed Barnes ME, Gozal D, Molfese DL (2012) Attention in children with obstructive sleep apnoea: an event-related potentials study. Sleep Med 13:368–377CrossRefPubMed
go back to reference Bartlett DJ, Rae C, Thompson CH, Byth K, Joffe DA, Enright T, Grunstein RR (2004) Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea. Sleep Med 5:593–596CrossRefPubMed Bartlett DJ, Rae C, Thompson CH, Byth K, Joffe DA, Enright T, Grunstein RR (2004) Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea. Sleep Med 5:593–596CrossRefPubMed
go back to reference Beebe DW, Gozal D (2002) Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res 11:1–16CrossRefPubMed Beebe DW, Gozal D (2002) Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res 11:1–16CrossRefPubMed
go back to reference Beebe DW, Groesz BA, Wells C, Nichols A, McGee K (2003) The neuropsychological effects of obstructive sleep apnea: a meta-analysis of norm-referenced and case-controlled data. Sleep 26:298–307PubMed Beebe DW, Groesz BA, Wells C, Nichols A, McGee K (2003) The neuropsychological effects of obstructive sleep apnea: a meta-analysis of norm-referenced and case-controlled data. Sleep 26:298–307PubMed
go back to reference Beebe DW, Wells CT, Jeffries J, Chini B, Kalra M, Amin R (2004) Neuropsychological effects of pediatric obstructive sleep apnea. J Int Neuropsychol Soc JINS 10:962–975CrossRefPubMed Beebe DW, Wells CT, Jeffries J, Chini B, Kalra M, Amin R (2004) Neuropsychological effects of pediatric obstructive sleep apnea. J Int Neuropsychol Soc JINS 10:962–975CrossRefPubMed
go back to reference Biggs SN, Bourke R, Anderson V, Jackman AR, Killedar A, Nixon GM, Davey MJ, Walker AM, Trinder J, Horne RS (2011) Working memory in children with sleep-disordered breathing: objective versus subjective measures. Sleep Med 12:887–891CrossRefPubMed Biggs SN, Bourke R, Anderson V, Jackman AR, Killedar A, Nixon GM, Davey MJ, Walker AM, Trinder J, Horne RS (2011) Working memory in children with sleep-disordered breathing: objective versus subjective measures. Sleep Med 12:887–891CrossRefPubMed
go back to reference Biggs SN, Vlahandonis A, Anderson V, Bourke R, Nixon GM, Davey MJ, Horne RS (2014) Long-term changes in neurocognition and behavior following treatment of sleep disordered breathing in school-aged children. Sleep 37:77–84PubMedPubMedCentral Biggs SN, Vlahandonis A, Anderson V, Bourke R, Nixon GM, Davey MJ, Horne RS (2014) Long-term changes in neurocognition and behavior following treatment of sleep disordered breathing in school-aged children. Sleep 37:77–84PubMedPubMedCentral
go back to reference Borges JG, Ginani GE, Hachul H, Cintra FD, Tufik S, Pompéia S (2013) Executive functioning in obstructive sleep apnea syndrome patients without comorbidities: focus on the fractionation of executive functions. J Clin Exp Neuropsychol 35:1094–1107CrossRefPubMed Borges JG, Ginani GE, Hachul H, Cintra FD, Tufik S, Pompéia S (2013) Executive functioning in obstructive sleep apnea syndrome patients without comorbidities: focus on the fractionation of executive functions. J Clin Exp Neuropsychol 35:1094–1107CrossRefPubMed
go back to reference Bourke R, Anderson V, Yang JS, Jackman AR, Killedar A, Nixon GM, Davey MJ, Walker AM, Trinder J, Horne RS (2011) Cognitive and academic functions are impaired in children with all severities of sleep-disordered breathing. Sleep Med 12:489–496CrossRefPubMed Bourke R, Anderson V, Yang JS, Jackman AR, Killedar A, Nixon GM, Davey MJ, Walker AM, Trinder J, Horne RS (2011) Cognitive and academic functions are impaired in children with all severities of sleep-disordered breathing. Sleep Med 12:489–496CrossRefPubMed
go back to reference Breslin J, Spano G, Bootzin R, Anand P, Nadel L, Edgin J (2014) Obstructive sleep apnea syndrome and cognition in Down syndrome. Dev Med Child Neurol 56:657–664CrossRefPubMed Breslin J, Spano G, Bootzin R, Anand P, Nadel L, Edgin J (2014) Obstructive sleep apnea syndrome and cognition in Down syndrome. Dev Med Child Neurol 56:657–664CrossRefPubMed
go back to reference Bucks RS, Olaithe M, Eastwood P (2013) Neurocognitive function in obstructive sleep apnoea: a meta-review. Respirology 18:61–70CrossRefPubMed Bucks RS, Olaithe M, Eastwood P (2013) Neurocognitive function in obstructive sleep apnoea: a meta-review. Respirology 18:61–70CrossRefPubMed
go back to reference Canessa N, Castronovo V, Cappa SF, Aloia MS, Marelli S, Falini A, Alemanno F, Ferini-Strambi L (2011) Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med 183:1419–2628CrossRefPubMed Canessa N, Castronovo V, Cappa SF, Aloia MS, Marelli S, Falini A, Alemanno F, Ferini-Strambi L (2011) Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med 183:1419–2628CrossRefPubMed
go back to reference Castronovo V, Scifo P, Castellano A, Aloia MS, Iadanza A, Marelli S, Cappa SF, Strambi LF, Falini A (2014) White matter integrity in obstructive sleep apnea before and after treatment. Sleep 37:sp-00071-13 Castronovo V, Scifo P, Castellano A, Aloia MS, Iadanza A, Marelli S, Cappa SF, Strambi LF, Falini A (2014) White matter integrity in obstructive sleep apnea before and after treatment. Sleep 37:sp-00071-13
go back to reference Chen X, Pensuksan WC, Lohsoonthorn V, Lertmaharit S, Gelaye B, Williams M (2014) Obstructive sleep apnea and multiple anthropometric indices of general obesity and abdominal obesity among young adults. Int J Soc Sci Stud 2:89–99PubMedPubMedCentral Chen X, Pensuksan WC, Lohsoonthorn V, Lertmaharit S, Gelaye B, Williams M (2014) Obstructive sleep apnea and multiple anthropometric indices of general obesity and abdominal obesity among young adults. Int J Soc Sci Stud 2:89–99PubMedPubMedCentral
go back to reference Djonlagic I, Guo M, Matteis P, Carusona A, Stickgold R, Malhotra A (2014) Untreated sleep-disordered breathing: links to aging-related decline in sleep-dependent memory consolidation. PLoS One 9:e85918CrossRefPubMedPubMedCentral Djonlagic I, Guo M, Matteis P, Carusona A, Stickgold R, Malhotra A (2014) Untreated sleep-disordered breathing: links to aging-related decline in sleep-dependent memory consolidation. PLoS One 9:e85918CrossRefPubMedPubMedCentral
go back to reference Esteller E, Barceló M, Segarra F, Estivill E, Girabent-Farrés M (2014) Neurocognitive and behavioral disturbances after adenotonsillectomy in obstructive sleep apnea syndrome. An Pediatr (Barc) 80:214–220CrossRef Esteller E, Barceló M, Segarra F, Estivill E, Girabent-Farrés M (2014) Neurocognitive and behavioral disturbances after adenotonsillectomy in obstructive sleep apnea syndrome. An Pediatr (Barc) 80:214–220CrossRef
go back to reference Felver-Gant JC, Bruce AS, Zimmerman M, Sweet LH, Millman RP, Aloia MS (2007) Working memory in obstructive sleep apnea: construct validity and treatment effects. J Clin Sleep Med 3:589–594PubMedPubMedCentral Felver-Gant JC, Bruce AS, Zimmerman M, Sweet LH, Millman RP, Aloia MS (2007) Working memory in obstructive sleep apnea: construct validity and treatment effects. J Clin Sleep Med 3:589–594PubMedPubMedCentral
go back to reference Ferini-Strambi L, Baietto C, Di Gioia MR, Castaldi P, Castronovo C, Zucconi M, Cappa SF (2003) Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP). Brain Res Bull 61:87–92CrossRefPubMed Ferini-Strambi L, Baietto C, Di Gioia MR, Castaldi P, Castronovo C, Zucconi M, Cappa SF (2003) Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP). Brain Res Bull 61:87–92CrossRefPubMed
go back to reference Findley LJ, Barth JT, Powers DC, Wilhoit SC, Boyd DG, Suratt PM (1986) Cognitive impairment in patients with obstructive sleep apnea and associated hypoxemia. Chest 90:686–690CrossRefPubMed Findley LJ, Barth JT, Powers DC, Wilhoit SC, Boyd DG, Suratt PM (1986) Cognitive impairment in patients with obstructive sleep apnea and associated hypoxemia. Chest 90:686–690CrossRefPubMed
go back to reference Gottlieb DJ, Chase C, Vezina RM, Heeren TC, Corwin MJ, Auerbach SH, Weese-Mayer DE, Lesko SM (2004) Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children. J Pediatr 145:458–464CrossRefPubMed Gottlieb DJ, Chase C, Vezina RM, Heeren TC, Corwin MJ, Auerbach SH, Weese-Mayer DE, Lesko SM (2004) Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children. J Pediatr 145:458–464CrossRefPubMed
go back to reference Greenberg GD, Watson RK, Deptula D (1987) Neuropsychological dysfunction in sleep apnea. Sleep 10:254–262PubMed Greenberg GD, Watson RK, Deptula D (1987) Neuropsychological dysfunction in sleep apnea. Sleep 10:254–262PubMed
go back to reference Grenèche J, Krieger J, Bertrand F, Erhardt C, Maumy M, Tassi P (2013) Effect of continuous positive airway pressure treatment on short-term memory performance over 24 h of sustained wakefulness in patients with obstructive sleep apnea-hypopnea syndrome. Sleep Med 14:964–972CrossRefPubMed Grenèche J, Krieger J, Bertrand F, Erhardt C, Maumy M, Tassi P (2013) Effect of continuous positive airway pressure treatment on short-term memory performance over 24 h of sustained wakefulness in patients with obstructive sleep apnea-hypopnea syndrome. Sleep Med 14:964–972CrossRefPubMed
go back to reference Guilleminault C, Eldridge FL, Tilkian A, Simmons FB, Dement WC (1977) Sleep apnea syndrome due to upper airway obstruction: a review of 25 cases. Arch Intern Med 137:296–300CrossRefPubMed Guilleminault C, Eldridge FL, Tilkian A, Simmons FB, Dement WC (1977) Sleep apnea syndrome due to upper airway obstruction: a review of 25 cases. Arch Intern Med 137:296–300CrossRefPubMed
go back to reference Hamasaki Uema SF, Nagata Pignatari SS, Fujita RR, Moreira GA, Pradella-Hallinan M, Weckx L (2007) Assessment of cognitive learning function in children with obstructive sleep breathing disorders. Braz J Otorhinolaryngol 73:315–320CrossRefPubMed Hamasaki Uema SF, Nagata Pignatari SS, Fujita RR, Moreira GA, Pradella-Hallinan M, Weckx L (2007) Assessment of cognitive learning function in children with obstructive sleep breathing disorders. Braz J Otorhinolaryngol 73:315–320CrossRefPubMed
go back to reference Hannon TS, Rofey DL, Ryan CM, Clapper DA, Chakravorty S, Arslanian SA (2012) Relationships among obstructive sleep apnea, anthropometric measures, and neurocognitive functioning in adolescents with severe obesity. J Pediatr 160:732–735CrossRefPubMed Hannon TS, Rofey DL, Ryan CM, Clapper DA, Chakravorty S, Arslanian SA (2012) Relationships among obstructive sleep apnea, anthropometric measures, and neurocognitive functioning in adolescents with severe obesity. J Pediatr 160:732–735CrossRefPubMed
go back to reference Health Quality Ontario (2006) Polysomnography in patients with obstructive sleep apnea: an evidence-based analysis. Ont Health Technol Assess Ser 6:1–38 Health Quality Ontario (2006) Polysomnography in patients with obstructive sleep apnea: an evidence-based analysis. Ont Health Technol Assess Ser 6:1–38
go back to reference Horiuchi F, Oka Y, Komori K, Tokui Y, Matsumoto T, Kawabe K, Ueno S (2014) Effects of adenotonsillectomy on neurocognitive function in pediatric obstructive sleep apnea syndrome. Case Rep Psychiatry. 2014:520215PubMedPubMedCentral Horiuchi F, Oka Y, Komori K, Tokui Y, Matsumoto T, Kawabe K, Ueno S (2014) Effects of adenotonsillectomy on neurocognitive function in pediatric obstructive sleep apnea syndrome. Case Rep Psychiatry. 2014:520215PubMedPubMedCentral
go back to reference Idiazabal-Alecha MA, Fernandez-Prats M (2014) Sleep-disordered breathing in early childhood: their neurocognitive repercussions. Revista de Neurol 58(Suppl 1):S83–S88 Idiazabal-Alecha MA, Fernandez-Prats M (2014) Sleep-disordered breathing in early childhood: their neurocognitive repercussions. Revista de Neurol 58(Suppl 1):S83–S88
go back to reference Jackman AR, Biggs SN, Walter LM, Embuldeniya US, Davey MJ, Nixon GM, Anderson V, Trinder J, Horne RS (2012) Sleep-disordered breathing in preschool children is associated with behavioral, but not cognitive, impairments. Sleep Med 13:621–631CrossRefPubMed Jackman AR, Biggs SN, Walter LM, Embuldeniya US, Davey MJ, Nixon GM, Anderson V, Trinder J, Horne RS (2012) Sleep-disordered breathing in preschool children is associated with behavioral, but not cognitive, impairments. Sleep Med 13:621–631CrossRefPubMed
go back to reference Joo EY, Jeon S, Kim ST, Lee JM, Hong SB (2013) Localized cortical thinning in patients with obstructive sleep apnea syndrome. Sleep 36:1153–1162PubMedPubMedCentral Joo EY, Jeon S, Kim ST, Lee JM, Hong SB (2013) Localized cortical thinning in patients with obstructive sleep apnea syndrome. Sleep 36:1153–1162PubMedPubMedCentral
go back to reference Jurádo-Gámez B, Guglielmi O, Gude F, Buela-Casal G (2015) Effects of continuous positive airway pressure treatment on cognitive functions in patients with severe obstructive sleep apnoea. Neurologia. doi:10.1016/j.nrl.2015.03.002 PubMed Jurádo-Gámez B, Guglielmi O, Gude F, Buela-Casal G (2015) Effects of continuous positive airway pressure treatment on cognitive functions in patients with severe obstructive sleep apnoea. Neurologia. doi:10.​1016/​j.​nrl.​2015.​03.​002 PubMed
go back to reference Kheirandish-Gozal L, Yoder K, Kulkarni R, Gozal D, Decety J (2014) Preliminary functional MRI neural correlates of executive functioning and empathy in children with obstructive sleep apnea. Sleep 37:587–592PubMedPubMedCentral Kheirandish-Gozal L, Yoder K, Kulkarni R, Gozal D, Decety J (2014) Preliminary functional MRI neural correlates of executive functioning and empathy in children with obstructive sleep apnea. Sleep 37:587–592PubMedPubMedCentral
go back to reference Klonoff H, Fleetham J, Taylor R, Clark C (1987) Treatment outcome of obstructive sleep apnea: physiological and neuropsychological con- comitants. J Nerv Men Dis 175:208–212CrossRef Klonoff H, Fleetham J, Taylor R, Clark C (1987) Treatment outcome of obstructive sleep apnea: physiological and neuropsychological con- comitants. J Nerv Men Dis 175:208–212CrossRef
go back to reference Kumar R, Farahvar S, Ogren JA, Macey PM, Thompson PM, Woo MA, Yang-Go FL, Harper RM (2014) Brain putamen volume changes in newly-diagnosed patients with obstructive sleep apnea. Neuroimage Clin 4:383–391CrossRefPubMedPubMedCentral Kumar R, Farahvar S, Ogren JA, Macey PM, Thompson PM, Woo MA, Yang-Go FL, Harper RM (2014) Brain putamen volume changes in newly-diagnosed patients with obstructive sleep apnea. Neuroimage Clin 4:383–391CrossRefPubMedPubMedCentral
go back to reference Kushida CA, Nichols DA, Holmes TH, Quan SF, Walsh JK, Gottlieb DJ, Simon RD, Guilleminault C, White DP, Goodwin JL, Schweitzer PK, Leary EB, Hyde PR, Hirshkowitz M, Green S, McEvoy LK, Chan C, Gevins A, Kay GG, Bloch DA, Crabtree T, Demen WC (2012) Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: the apnea positive pressure long-term efficacy study (APPLES). Sleep 35:1593–1602PubMedPubMedCentral Kushida CA, Nichols DA, Holmes TH, Quan SF, Walsh JK, Gottlieb DJ, Simon RD, Guilleminault C, White DP, Goodwin JL, Schweitzer PK, Leary EB, Hyde PR, Hirshkowitz M, Green S, McEvoy LK, Chan C, Gevins A, Kay GG, Bloch DA, Crabtree T, Demen WC (2012) Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: the apnea positive pressure long-term efficacy study (APPLES). Sleep 35:1593–1602PubMedPubMedCentral
go back to reference Lal C, White DR, Joseph JE, van Bakergem K, LaRosa A (2015) Sleep-disordered breathing in Down syndrome. Chest 147:570–579CrossRefPubMed Lal C, White DR, Joseph JE, van Bakergem K, LaRosa A (2015) Sleep-disordered breathing in Down syndrome. Chest 147:570–579CrossRefPubMed
go back to reference Lau EY, Eskes GA, Morrison DL, Rajda M, Spurr KF (2010) Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure. J Int Neuropsychol Soc 16:1077–1088CrossRefPubMed Lau EY, Eskes GA, Morrison DL, Rajda M, Spurr KF (2010) Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure. J Int Neuropsychol Soc 16:1077–1088CrossRefPubMed
go back to reference Lau EY, Choi EW, Lai ES, Lau KN, Au CT, Yung WH, Li AM (2015) Working memory impairment and its associated sleep-related respiratory parameters in children with obstructive sleep apnea. Sleep Med 16:1109–1115CrossRefPubMed Lau EY, Choi EW, Lai ES, Lau KN, Au CT, Yung WH, Li AM (2015) Working memory impairment and its associated sleep-related respiratory parameters in children with obstructive sleep apnea. Sleep Med 16:1109–1115CrossRefPubMed
go back to reference Lee LA, Li HY, Lin YS, Fang TJ, Huang YS, Hsu JF, Wu CM, Huang CG (2014) Severity of childhood obstructive sleep apnea and hypertension improved after adenotonsillectomy. Otolaryngol Head Neck Surg Off J Am Acad Otolaryngol Head Neck Surg. doi:10.1177/0194599814561203 Lee LA, Li HY, Lin YS, Fang TJ, Huang YS, Hsu JF, Wu CM, Huang CG (2014) Severity of childhood obstructive sleep apnea and hypertension improved after adenotonsillectomy. Otolaryngol Head Neck Surg Off J Am Acad Otolaryngol Head Neck Surg. doi:10.​1177/​0194599814561203​
go back to reference Lis S, Krieger S, Hennig D, Röder C, Kirsch P, Seeger W, Gallhofer B, Schulz R (2008) Executive functions and cognitive subprocesses in patients with obstructive sleep apnoea. J Sleep Res 17:271–280CrossRefPubMed Lis S, Krieger S, Hennig D, Röder C, Kirsch P, Seeger W, Gallhofer B, Schulz R (2008) Executive functions and cognitive subprocesses in patients with obstructive sleep apnoea. J Sleep Res 17:271–280CrossRefPubMed
go back to reference Liu H, Yuan X (2014) The difference and similarity of obesity hypoventilation syndrome and obstructive sleep apnea hypopnea syndrome. Chin J Tuberc Respir Dis 37:85–87 Liu H, Yuan X (2014) The difference and similarity of obesity hypoventilation syndrome and obstructive sleep apnea hypopnea syndrome. Chin J Tuberc Respir Dis 37:85–87
go back to reference Macey PM, Kumar R, Woo MA, Valladares EM, Yan-Go FL, Harper RM (2008) Brain structural changes in obstructive sleep apnea. Sleep 31:967–977PubMedPubMedCentral Macey PM, Kumar R, Woo MA, Valladares EM, Yan-Go FL, Harper RM (2008) Brain structural changes in obstructive sleep apnea. Sleep 31:967–977PubMedPubMedCentral
go back to reference Marcus CL, Moore RH, Rosen CL, Giordani B, Garetz SL, Taylor HG, Mitchell RB, Amin R, Katz ES, Arens R, Paruthi S, Muzumdar H, Gozal D, Thomas NH, Ware J, Beebe D, Snyder K, Elden L, Sprecher RC, Willging P, Jones D, Bent JP, Hoban T, Chervin RD, Ellenberg SS, Redline S, Childhood Adenotonsillectomy Trial (CHAT) (2013) A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med 368(25):2366–2376CrossRefPubMedPubMedCentral Marcus CL, Moore RH, Rosen CL, Giordani B, Garetz SL, Taylor HG, Mitchell RB, Amin R, Katz ES, Arens R, Paruthi S, Muzumdar H, Gozal D, Thomas NH, Ware J, Beebe D, Snyder K, Elden L, Sprecher RC, Willging P, Jones D, Bent JP, Hoban T, Chervin RD, Ellenberg SS, Redline S, Childhood Adenotonsillectomy Trial (CHAT) (2013) A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med 368(25):2366–2376CrossRefPubMedPubMedCentral
go back to reference Martin MS, Sforza E, Roche F, Barthelemy JC, Thomas-Anterion C (2014) Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. The proof-synapse cohort. Sleep Martin MS, Sforza E, Roche F, Barthelemy JC, Thomas-Anterion C (2014) Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. The proof-synapse cohort. Sleep
go back to reference Mazza S, Pépin JL, Naëgelé B, Plante J, Deschaux C, Lévy P (2005) Most obstructive sleep apnoea patients exhibit vigilance and attention deficits on an extended battery of tests. Eur Respir J 25:75–80CrossRefPubMed Mazza S, Pépin JL, Naëgelé B, Plante J, Deschaux C, Lévy P (2005) Most obstructive sleep apnoea patients exhibit vigilance and attention deficits on an extended battery of tests. Eur Respir J 25:75–80CrossRefPubMed
go back to reference Miano S, Paolino MC, Urbano A, Parisi P, Massolo AC, Castaldo R, Villa MP (2011) Neurocognitive assessment and sleep analysis in children with sleep-disordered breathing. Clin Neurophysiol Off J Int Fed Clin Neurophysiol 122:311–319CrossRef Miano S, Paolino MC, Urbano A, Parisi P, Massolo AC, Castaldo R, Villa MP (2011) Neurocognitive assessment and sleep analysis in children with sleep-disordered breathing. Clin Neurophysiol Off J Int Fed Clin Neurophysiol 122:311–319CrossRef
go back to reference Morrell MJ, McRobbie DW, Quest RA, Cummin AR, Ghiassi R, Corfield DR (2003) Changes in brain morphology associated with obstructive sleep apnea. Sleep Med 4:451–454CrossRefPubMed Morrell MJ, McRobbie DW, Quest RA, Cummin AR, Ghiassi R, Corfield DR (2003) Changes in brain morphology associated with obstructive sleep apnea. Sleep Med 4:451–454CrossRefPubMed
go back to reference Naëgelé B, Launois SH, Mazza S, Feuerstein C, Pépin JL, Lévy P (2006) Which memory processes are affected in patients with obstructive sleep apnea? An evaluation of 3 types of memory. Sleep 29:533–544PubMed Naëgelé B, Launois SH, Mazza S, Feuerstein C, Pépin JL, Lévy P (2006) Which memory processes are affected in patients with obstructive sleep apnea? An evaluation of 3 types of memory. Sleep 29:533–544PubMed
go back to reference Nemeth D, Csábi E, Janacsek K, Várszegi M, Mari Z (2012) Intact implicit probabilistic sequence learning in obstructive sleep apnea. J Sleep Res 21:396–401CrossRefPubMed Nemeth D, Csábi E, Janacsek K, Várszegi M, Mari Z (2012) Intact implicit probabilistic sequence learning in obstructive sleep apnea. J Sleep Res 21:396–401CrossRefPubMed
go back to reference O’Brien LM, Mervis CB, Holbrook CR, Bruner JL, Smith NH, McNally N, McClimment MC, Gozal D (2004) Neurobehavioral correlates of sleep-disordered breathing in children. J Sleep Res 13:165–172CrossRefPubMed O’Brien LM, Mervis CB, Holbrook CR, Bruner JL, Smith NH, McNally N, McClimment MC, Gozal D (2004) Neurobehavioral correlates of sleep-disordered breathing in children. J Sleep Res 13:165–172CrossRefPubMed
go back to reference O’Donoghue FJ, Briellmann RS, Rochford PD, Abbott DF, Pell GS, Chan CH, Tarquinio N, Jackson GD, Pierce RJ (2005) Cerebral structural changes in severe obstructive sleep apnea. Am J Respir Crit Care Med 171:1185–1190CrossRefPubMed O’Donoghue FJ, Briellmann RS, Rochford PD, Abbott DF, Pell GS, Chan CH, Tarquinio N, Jackson GD, Pierce RJ (2005) Cerebral structural changes in severe obstructive sleep apnea. Am J Respir Crit Care Med 171:1185–1190CrossRefPubMed
go back to reference Paiva T, Attarian H (2014) Obstructive sleep apnea and other sleep-related syndromes. Handb Clin Neurol 119:251–271CrossRefPubMed Paiva T, Attarian H (2014) Obstructive sleep apnea and other sleep-related syndromes. Handb Clin Neurol 119:251–271CrossRefPubMed
go back to reference Pierobon A, Giardini A, Fanfulla F, Callegari S, Majani G (2008) A multidimensional assessment of obese patients with obstructive sleep apnoea syndrome (OSAS): a study of psychological, neuropsychological and clinical relationships in a disabling multifaceted disease. Sleep Med 9:882–889CrossRefPubMed Pierobon A, Giardini A, Fanfulla F, Callegari S, Majani G (2008) A multidimensional assessment of obese patients with obstructive sleep apnoea syndrome (OSAS): a study of psychological, neuropsychological and clinical relationships in a disabling multifaceted disease. Sleep Med 9:882–889CrossRefPubMed
go back to reference Quan SF, Wright R, Baldwin CM, Kaemingk KL, Goodwin JL, Kuo TF, Kaszniak A, Boland LL, Caccappolo E, Bootzin RR (2006) Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study. Sleep Med 7:498–507CrossRefPubMed Quan SF, Wright R, Baldwin CM, Kaemingk KL, Goodwin JL, Kuo TF, Kaszniak A, Boland LL, Caccappolo E, Bootzin RR (2006) Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study. Sleep Med 7:498–507CrossRefPubMed
go back to reference Quan SF, Archbold K, Gevins AS, Goodwin JL (2013) Long-term neurophysiologic impact of childhood sleep disordered breathing on neurocognitive performance. Southwest J Pulm Crit Care 7:165–175CrossRefPubMedPubMedCentral Quan SF, Archbold K, Gevins AS, Goodwin JL (2013) Long-term neurophysiologic impact of childhood sleep disordered breathing on neurocognitive performance. Southwest J Pulm Crit Care 7:165–175CrossRefPubMedPubMedCentral
go back to reference Rezaeitalab F, Moharrari F, Saberi S, Asadpour H, Rezaeetalab F (2014) The correlation of anxiety and depression with obstructive sleep apnea syndrome. J Res Med Sci Off J Isfahan Univ Med Sci 19:205–210 Rezaeitalab F, Moharrari F, Saberi S, Asadpour H, Rezaeetalab F (2014) The correlation of anxiety and depression with obstructive sleep apnea syndrome. J Res Med Sci Off J Isfahan Univ Med Sci 19:205–210
go back to reference Rouleau I, Décary A, Chicoine AJ, Montplaisir J (2002) Procedural skill learning in obstructive sleep apnea syndrome. Sleep 25:401–411PubMed Rouleau I, Décary A, Chicoine AJ, Montplaisir J (2002) Procedural skill learning in obstructive sleep apnea syndrome. Sleep 25:401–411PubMed
go back to reference Ryan S, Crinion SJ, McNicholas WT (2014) Obesity and sleep-disordered breathing- when two ‘bad guys’ meet. QJM Mon J Assoc Physicians 107:949–954CrossRef Ryan S, Crinion SJ, McNicholas WT (2014) Obesity and sleep-disordered breathing- when two ‘bad guys’ meet. QJM Mon J Assoc Physicians 107:949–954CrossRef
go back to reference Sales LV, Bruin VM, D’Almeida V, Pompeia S, Bueno OF, Tufik S, Bittencourt L (2013) Cognition and biomarkers of oxidative stress in obstructive sleep apnea. Clinics (Sao Paulo) 68:449–455CrossRef Sales LV, Bruin VM, D’Almeida V, Pompeia S, Bueno OF, Tufik S, Bittencourt L (2013) Cognition and biomarkers of oxidative stress in obstructive sleep apnea. Clinics (Sao Paulo) 68:449–455CrossRef
go back to reference Saunamäki T, Jehkonen M (2007) A review of executive functions in obstructive sleep apnea syndrome. Acta Neurol Scand 115:1–11CrossRefPubMed Saunamäki T, Jehkonen M (2007) A review of executive functions in obstructive sleep apnea syndrome. Acta Neurol Scand 115:1–11CrossRefPubMed
go back to reference Saunamäki T, Himanen SL, Polo O, Jehkonen M (2009) Executive dysfunction in patients with obstructive sleep apnea syndrome. Eur Neurol 62:237–242CrossRefPubMed Saunamäki T, Himanen SL, Polo O, Jehkonen M (2009) Executive dysfunction in patients with obstructive sleep apnea syndrome. Eur Neurol 62:237–242CrossRefPubMed
go back to reference Sforza E, Haba-Rubio J, De Bilbao F, Rochat T, Ibanez V (2004) Performance vigilance task and sleepiness in patients with sleep-disordered breathing. Eur Respir J 24:279–285CrossRefPubMed Sforza E, Haba-Rubio J, De Bilbao F, Rochat T, Ibanez V (2004) Performance vigilance task and sleepiness in patients with sleep-disordered breathing. Eur Respir J 24:279–285CrossRefPubMed
go back to reference Solyom R, Csiszer I, Neagos A (2014) Tonsillar hypertrophy implications in sleep disorders in adults and children. Rom J Morphol Embryol 55(2 Suppl):603–606PubMed Solyom R, Csiszer I, Neagos A (2014) Tonsillar hypertrophy implications in sleep disorders in adults and children. Rom J Morphol Embryol 55(2 Suppl):603–606PubMed
go back to reference Tan E, Healey D, Schaughency E, Dawes P, Galland B (2014) Neurobehavioural correlates inolder children and adolescents with obesity and obstructive sleep apnoea. J Paediatr Child Health 50:16–23CrossRefPubMed Tan E, Healey D, Schaughency E, Dawes P, Galland B (2014) Neurobehavioural correlates inolder children and adolescents with obesity and obstructive sleep apnoea. J Paediatr Child Health 50:16–23CrossRefPubMed
go back to reference Thomas RJ, Rosen BR, Stern CE, Weiss JW, Kwong KK (2005) Functional imaging of working memory in obstructive sleep-disordered breathing. J Appl Physiol 98:2226–2234CrossRefPubMed Thomas RJ, Rosen BR, Stern CE, Weiss JW, Kwong KK (2005) Functional imaging of working memory in obstructive sleep-disordered breathing. J Appl Physiol 98:2226–2234CrossRefPubMed
go back to reference Torelli F, Moscufo N, Garreffa G, Placidi F, Romigi A, Zannino S, Bozzali M, Fasano F, Giulietti G, Djonlagic I, Malhotra A, Marciani MG, Guttmann CRG (2011) Cognitive profile and brain morphological changes in obstructive sleep apnea. NeuroImage 54:787–793CrossRefPubMed Torelli F, Moscufo N, Garreffa G, Placidi F, Romigi A, Zannino S, Bozzali M, Fasano F, Giulietti G, Djonlagic I, Malhotra A, Marciani MG, Guttmann CRG (2011) Cognitive profile and brain morphological changes in obstructive sleep apnea. NeuroImage 54:787–793CrossRefPubMed
go back to reference Tulek B, Atalay NB, Kanat F, Suerdem M (2013) Attentional control is partially impaired in obstructive sleep apnea syndrome. J Sleep Res 22:422–429CrossRefPubMed Tulek B, Atalay NB, Kanat F, Suerdem M (2013) Attentional control is partially impaired in obstructive sleep apnea syndrome. J Sleep Res 22:422–429CrossRefPubMed
go back to reference Twigg GL, Papaioannou I, Jackson M, Ghiassi R, Shaikh Z, Jaye J, Graham KS, Simonds AK, Morrell MJ (2010) Obstructive sleep apnea syndrome is associated with deficits in verbal but not visual memory. Am J Respir Crit Care 182:8–103CrossRef Twigg GL, Papaioannou I, Jackson M, Ghiassi R, Shaikh Z, Jaye J, Graham KS, Simonds AK, Morrell MJ (2010) Obstructive sleep apnea syndrome is associated with deficits in verbal but not visual memory. Am J Respir Crit Care 182:8–103CrossRef
go back to reference Varga AW, Kishi A, Mantua J, Lim J, Koushyk V, Leibert DP, Osorio RS, Rapoport DM, Ayappa I (2014) Apnea-induced rapid eye movement sleep disruption impairs human spatial navigational memory. J Neurosci Off J Soc Neurosci 34:14571–14577CrossRef Varga AW, Kishi A, Mantua J, Lim J, Koushyk V, Leibert DP, Osorio RS, Rapoport DM, Ayappa I (2014) Apnea-induced rapid eye movement sleep disruption impairs human spatial navigational memory. J Neurosci Off J Soc Neurosci 34:14571–14577CrossRef
go back to reference Verstraeten E, Cluydts R, Pevernagie D, Hoffman G (2004) Executive function in sleep apnea: controlling for attentional capacity in assessing executive attention. Sleep 27:685–693PubMed Verstraeten E, Cluydts R, Pevernagie D, Hoffman G (2004) Executive function in sleep apnea: controlling for attentional capacity in assessing executive attention. Sleep 27:685–693PubMed
go back to reference Vitelli O, Tabarrini A, Miano S, Rabasco J, Pietropaoli N, Forlani M, Parisi P, Villa MP (2015) Impact of obesity on cognitive outcome in children with sleep-disordered breathing. Sleep Med 16:625–630CrossRefPubMed Vitelli O, Tabarrini A, Miano S, Rabasco J, Pietropaoli N, Forlani M, Parisi P, Villa MP (2015) Impact of obesity on cognitive outcome in children with sleep-disordered breathing. Sleep Med 16:625–630CrossRefPubMed
go back to reference Xanthopoulos MS, Gallagher PR, Berkowitz RI, Radcliffe J, Bradford R, Marcus CL (2014) Neurobehavioral functioning in adolescents with and without obesity and obstructive sleep apnea. Sleep. pii: sp-00197-14 Xanthopoulos MS, Gallagher PR, Berkowitz RI, Radcliffe J, Bradford R, Marcus CL (2014) Neurobehavioral functioning in adolescents with and without obesity and obstructive sleep apnea. Sleep. pii: sp-00197-14
go back to reference Yaouhi K, Bertran F, Clochon P, Mézenge F, Denise P, Foret J, Eustache F, Desgranges B (2009) A combined neuropsychological and brain imaging study of obstructive sleep apnea. J Sleep Res 18:36–48CrossRefPubMed Yaouhi K, Bertran F, Clochon P, Mézenge F, Denise P, Foret J, Eustache F, Desgranges B (2009) A combined neuropsychological and brain imaging study of obstructive sleep apnea. J Sleep Res 18:36–48CrossRefPubMed
go back to reference Yuan HC, Sohn EY, Abouezzeddine T, Mahrer NE, Barber BA, Keens TG, Davidson Ward SL, Gold JI (2012) Neurocognitive functioning in children with obstructive sleep apnea syndrome: a pilot study of positive airway pressure therapy. J Pediatr Nurs 27:607–613CrossRefPubMed Yuan HC, Sohn EY, Abouezzeddine T, Mahrer NE, Barber BA, Keens TG, Davidson Ward SL, Gold JI (2012) Neurocognitive functioning in children with obstructive sleep apnea syndrome: a pilot study of positive airway pressure therapy. J Pediatr Nurs 27:607–613CrossRefPubMed
go back to reference Zawada K, Burzynska-Kozmin A, Krysta K (2013) Patients with obesity hypoventilation syndrome and mental disorders. Eur Psychiatry 28:1CrossRef Zawada K, Burzynska-Kozmin A, Krysta K (2013) Patients with obesity hypoventilation syndrome and mental disorders. Eur Psychiatry 28:1CrossRef
go back to reference Zhang X, Ma L, Li S, Wang Y, Wang L (2011) A functional MRI evaluation of frontal dysfunction in patients with severe obstructive sleep apnea. Sleep Med 12:335–340CrossRefPubMed Zhang X, Ma L, Li S, Wang Y, Wang L (2011) A functional MRI evaluation of frontal dysfunction in patients with severe obstructive sleep apnea. Sleep Med 12:335–340CrossRefPubMed
Metadata
Title
Cognitive deficits in adults with obstructive sleep apnea compared to children and adolescents
Authors
Krzysztof Krysta
Agnieszka Bratek
Karolina Zawada
Radosław Stepańczak
Publication date
01-02-2017
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue Special Issue 1/2017
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-015-1501-6

Other articles of this Special Issue 1/2017

Journal of Neural Transmission 1/2017 Go to the issue

Psychiatry and Preclinical Psychiatric Studies - Review Article

Sleep-dependent memory consolidation and its implications for psychiatry

Psychiatry and Preclinical Psychiatric Studies - Original Article

Blink rate and blink timing in children with ADHD and the influence of stimulant medication

Psychiatry and Preclinical Psychiatric Studies - Original Article

Sustained attention in adult ADHD: time-on-task effects of various measures of attention

Psychiatry and Preclinical Psychiatric Studies - Review article

Current source density analysis of resting state EEG in depression: a review