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Open Access 01-06-2015 | Neurology and Preclinical Neurological Studies - Short communication

Basal ganglia echogenicity in tauopathies

Authors: Krzysztof Sadowski, Małgorzata Serafin-Król, Karol Szlachta, Andrzej Friedman

Published in: Journal of Neural Transmission | Issue 6/2015

Abstract

Accumulating data confirm the usefulness of transcranial sonography (TCS) in the diagnosis of Parkinson’s disease. The relevance of basal ganglia abnormalities depicted by TCS in atypical parkinsonian syndromes still needs further assessment. In the present study, 20 patients with progressive supranuclear palsy (PSP) and 13 patients with corticobasal syndrome (CBS) were studied with the use of transcranial sonography. Echogenicity of the substantia nigra (SN) and lenticular nucleus (LN) were assessed. 0/20 patients with PSP and 8/12 (66.6 %) patients with CBS were characterized with SN hyperechogenicity. LN hyperechogenicity was observed in 9/20 patients diagnosed with PSP and 0/11 of CBS patients. The combination of SN isoechogenicity and LN hyperechogenicity reached 100 % sensitivity and positive predictive value for the diagnosis of PSP. The results of this study point out that CBS has to be taken into consideration when SN hyperechogenicity is depicted in a patient with parkinsonian syndrome. Normal echogenicity of the SN coexisting with LN hyperechogenicity practically excludes CBS.

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Title: Basal ganglia echogenicity in tauopathies
Authors: Krzysztof Sadowski
Małgorzata Serafin-Król
Karol Szlachta
Andrzej Friedman
Publication date: 01-06-2015
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 6/2015
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-014-1310-3

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Basal ganglia echogenicity in tauopathies

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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