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01-10-2013 | Psychiatry and Preclinical Psychiatric Studies - Original Article

MR and GR functional SNPs may modulate tobacco smoking susceptibility

Authors: Diego L. Rovaris, Nina R. Mota, Lucas A. de Azeredo, Renata B. Cupertino, Guilherme P. Bertuzzi, Evelise R. Polina, Verônica Contini, Gustavo L. Kortmann, Eduardo S. Vitola, Eugenio H. Grevet, Rodrigo Grassi-Oliveira, Sidia M. Callegari-Jacques, Claiton H. D. Bau

Published in: Journal of Neural Transmission | Issue 10/2013

Abstract

A number of studies have demonstrated that stress is involved in all aspects of smoking behavior, including initiation, maintenance and relapse. The mineralocorticoid (MR) and glucocorticoid (GR) receptors are expressed in several brain areas and play a key role in negative feedback of the hypothalamic–pituitary–adrenal (HPA) axis. As nicotine increases the activation of the HPA axis, we wondered if functional SNPs (single nucleotide polymorphisms) in MR and GR coding genes (NR3C2 rs5522 and NR3C1 rs6198, respectively) may be involved in smoking susceptibility. The sample included 627 volunteers, of which 514 were never-smokers and 113 lifetime smokers. We report an interaction effect between rs5522 and rs6198 SNPs. The odds ratio (OR) for the presence of the NR3C2 rs5522 Val allele in NR3C1 rs6198 G carriers was 0.18 (P = 0.007), while in rs6198 G noncarriers the OR was 1.83 (P = 0.027). We also found main effects of the NR3C1 rs6198 G allele on number of cigarettes smoked per day (P = 0.027) and in total score of the Fagerström Test for Nicotine Dependence (P = 0.007). These findings are consistent with a possible link between NR3C2 and NR3C1 polymorphisms and smoking behavior and provide a first partial replication for a nominally significant GWAS finding between NR3C2 and tobacco smoking.

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Title: MR and GR functional SNPs may modulate tobacco smoking susceptibility
Authors: Diego L. Rovaris
Nina R. Mota
Lucas A. de Azeredo
Renata B. Cupertino
Guilherme P. Bertuzzi
Evelise R. Polina
Verônica Contini
Gustavo L. Kortmann
Eduardo S. Vitola
Eugenio H. Grevet
Rodrigo Grassi-Oliveira
Sidia M. Callegari-Jacques
Claiton H. D. Bau
Publication date: 01-10-2013
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 10/2013
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1012-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

MR and GR functional SNPs may modulate tobacco smoking susceptibility

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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