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01-07-2011 | Basic Neurosciences, Genetics and Immunology - Review Article

Hepatic consequences of vascular adhesion protein-1 expression

Authors: Chris J. Weston, David H. Adams

Published in: Journal of Neural Transmission | Issue 7/2011

Abstract

The liver is constantly exposed to antigens present in the blood and to particulate antigens delivered from the gut. To maintain effective levels of immune surveillance and yet tolerate food antigens, the hepatic environment has become highly specialised. A low flow environment exists within the hepatic sinusoids that not only facilitates the exchange of toxins and nutrients within the liver parenchyma, but also provides an ideal niche for the recruitment of leukocytes. One such adhesion molecule involved in this process, the vascular adhesion protein-1 (VAP-1), is unusual in the context of the leukocyte adhesion cascade in that it is both an adhesion molecule and a primary amine oxidase. In this review, we examine the biological functions of VAP-1 and examine what role this molecule might play in the establishment and progression of chronic liver disease.

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Title: Hepatic consequences of vascular adhesion protein-1 expression
Authors: Chris J. Weston
David H. Adams
Publication date: 01-07-2011
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 7/2011
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-011-0647-0

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Hepatic consequences of vascular adhesion protein-1 expression

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