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01-08-2009 | Basic Neurosciences, Genetics and Immunology - Original Article

Possible role of receptor heteromers in multiple sclerosis

Authors: A. O. Tarakanov, K. G. Fuxe, L. F. Agnati, L. B. Goncharova

Published in: Journal of Neural Transmission | Issue 8/2009

Abstract

Recent results suggest that cytokine and glutamate receptors can interact directly and form receptor heteromers. Due to such heteromers, cytokines can act not only as classical neuromediators but also directly enhance glutamate gated ion channel activity via allosteric mechanisms. Our opinion is that such heteromers may lead to enhanced glutamate neurotoxicity in pathogenic processes of multiple sclerosis. Thus, agents targeting evolutionary conserved leucine-rich motifs responsible for such dimerization of receptors may represent a useful strategy to inhibit excitotoxicity in multiple sclerosis.

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Title: Possible role of receptor heteromers in multiple sclerosis
Authors: A. O. Tarakanov
K. G. Fuxe
L. F. Agnati
L. B. Goncharova
Publication date: 01-08-2009
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 8/2009
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-009-0197-x

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Possible role of receptor heteromers in multiple sclerosis

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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