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Open Access 01-03-2009 | Basic Neurosciences, Genetics and Immunology - Original Article

Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis

Authors: Daniel Martins-de-Souza, Wagner F. Gattaz, Andrea Schmitt, Christiane Rewerts, Sérgio Marangoni, José C. Novello, Giuseppina Maccarrone, Christoph W. Turck, Emmanuel Dias-Neto

Published in: Journal of Neural Transmission | Issue 3/2009

Abstract

Global proteomic analysis of post-mortem anterior temporal lobe samples from schizophrenia patients and non-schizophrenia individuals was performed using stable isotope labeling and shotgun proteomics. Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically significant differential expression. Pathways affected by differential protein expression include transport, signal transduction, energy pathways, cell growth and maintenance and protein metabolism. The collection of protein alterations identified here reinforces the importance of myelin/oligodendrocyte and calcium homeostasis in schizophrenia, and reveals a number of new potential markers that may contribute to the understanding of the pathogenesis of this complex disease.

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Title: Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis
Authors: Daniel Martins-de-Souza
Wagner F. Gattaz
Andrea Schmitt
Christiane Rewerts
Sérgio Marangoni
José C. Novello
Giuseppina Maccarrone
Christoph W. Turck
Emmanuel Dias-Neto
Publication date: 01-03-2009
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 3/2009
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0156-y

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Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis

Abstract

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Abstract

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