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01-08-2008 | Basic Neurosciences, Genetics and Immunology - Original Article

Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects

Authors: Marianne Gorlyn, John G. Keilp, Michael F. Grunebaum, Bonnie P. Taylor, Maria A. Oquendo, Gerard E. Bruder, Jonathan W. Stewart, Gil Zalsman, J. John Mann

Published in: Journal of Neural Transmission | Issue 8/2008

Abstract

Studies suggest that neuropsychological measures may provide prognostic information regarding SSRI treatment response, yet it is unclear which specific cognitive domains are the most effectual predictors. The aim of this study was to characterize the cognitive profile associated with SSRI nonresponse using a comprehensive set of neuropsychological tests. Participants (N = 32) met criteria for current major depressive episode. Assessment followed pre-treatment medication washout. Clinical response was measured after 3-month open-label SSRI treatment. Groups did not differ by demographic characteristics, intelligence or depression severity. Responders outperformed nonresponders across all cognitive domains, with the largest differences observed in executive, language and working memory functions. Results indicate poorer global cognitive functioning is predictive of treatment nonresponse. Deficits were most pronounced in tests demanding greater mental search and manipulation rather than speeded motor output. Cognitive slowing may mediate the working memory and executive function deficits found in nonresponders. These findings can inform exploration for pharmacogenetic endophenotypes.

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Title: Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects
Authors: Marianne Gorlyn
John G. Keilp
Michael F. Grunebaum
Bonnie P. Taylor
Maria A. Oquendo
Gerard E. Bruder
Jonathan W. Stewart
Gil Zalsman
J. John Mann
Publication date: 01-08-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 8/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0084-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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