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01-06-2008 | Alzheimer's Disease and Related Disorders - Short Communication

Aromatase and interleukin-10 genetic variants interactively modulate Alzheimer’s disease risk

Authors: O. Combarros, P. Sánchez-Juan, J. A. Riancho, I. Mateo, E. Rodríguez-Rodríguez, J. Infante, I. García-Gorostiaga, J. L. Vázquez-Higuera, J. Berciano

Published in: Journal of Neural Transmission | Issue 6/2008

Abstract

A chronic inflammatory process with activation of microglial cells contribute to the neurodegeneration associated with Alzheimer’s disease (AD). Estrogen could protect the brain from neurodegeneration by augmenting the secretion of the anti-inflammatory interleukin (IL)-10 from microglial cells. In a case–control study in 231 AD patients and 194 healthy controls, we examined whether the combined effects between the genes coding for aromatase (a critical enzyme in the peripheral synthesis of estrogens) and IL-10 might be responsible for susceptibility to AD. Subjects carrying both the aromatase (5´-UTR) GG and the IL-10 (−1082) GG genotypes had a six times lower risk of developing AD than subjects without these risk genotypes (OR = 0.17, 95% CI = 0.04–0.77, P = 0.02).

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Title: Aromatase and interleukin-10 genetic variants interactively modulate Alzheimer’s disease risk
Authors: O. Combarros
P. Sánchez-Juan
J. A. Riancho
I. Mateo
E. Rodríguez-Rodríguez
J. Infante
I. García-Gorostiaga
J. L. Vázquez-Higuera
J. Berciano
Publication date: 01-06-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 6/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0028-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Aromatase and interleukin-10 genetic variants interactively modulate Alzheimer’s disease risk

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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