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01-08-2012 | Experimental Research

The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit

Authors: Hayri Kertmen, Bora Gürer, Erdal Resit Yilmaz, Ata Türker Arikok, Adnan Demirci, Salih Metin Gökyaprak, Zeki Sekerci

Published in: Acta Neurochirurgica | Issue 8/2012

Abstract

Background

This study investigated the effects of thiocolchicoside to prevent cerebral vasospasm in a rabbit model of subarachnoid hemorrhage.

Methods

Twenty-four adult male New Zealand white rabbits were randomly divided into three groups of eight rabbits each: group 1 (control), group 2 (subarachnoid hemorrhage), group 3 (treatment). Thiocolchicoside (4 mg/kg, intraperitoneally) was administered just before intracisternal blood injection and continued for 72 h once a day in the same dose for group 3. Animals were killed 72 h after subarachnoid hemorrhage. Basilar artery cross-sectional areas and arterial wall thicknesses were measured in all groups.

Results

Intraperitoneal administration of thiocolchicoside was found to attenuate cerebral vasospasm after subarachnoid hemorrhage in rabbits. Thiocolchicoside treatment was determined to be effective in increasing the luminal area and reducing the wall thickness of the basilar artery.

Conclusions

Our findings, for the first time, showed that TCC can prevent vasospasm induced by SAH. Our results also showed that GABAergic activity may play an important role in cerebral vasospasm etiopathogenesis. In conclusion, the thiocolchicoside treatment might be beneficial in preventing vasospasm after subarachnoid hemorrhage, thus showing potential for clinical application.

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Title: The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit
Authors: Hayri Kertmen
Bora Gürer
Erdal Resit Yilmaz
Ata Türker Arikok
Adnan Demirci
Salih Metin Gökyaprak
Zeki Sekerci
Publication date: 01-08-2012
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 8/2012
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-012-1420-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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