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Acta Neurochirurgica

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Open Access 01-03-2011 | Clinical Article

Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study

Authors: Hans Christoph Bock, Joseph Cohnen, Naureen Keric, Sven Rainer Kantelhardt, Alf Giese

Published in: Acta Neurochirurgica | Issue 3/2011

Abstract

Background

Implantation of 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) wafer for malignant glioma is not recommended in the case of surgical opening of the ventricular system during microsurgical tumor resection because the wafer material may dislocate from the resection cavity into the ventricular system and cause obstructive hydrocephalus. TachoSil is an adhesive collagen fleece used in different surgical disciplines that provides an air- and liquid-tight seal closing communications between the ventricular system and the resection cavity after tumor removal.

Methods

Occlusion of ventricular defects with TachoSil after microsurgical glioma resection was performed in two patients with newly diagnosed and seven patients with recurrent malignant glioma prior to BCNU wafer implantation into the resection cavity. Early postoperative cranial computed tomography (CCT)/MRI and follow-up MRI at 3 months’ intervals were performed with a median follow-up of 10.4 months.

Results

The collagen fleece was identified as a linear structure hypodense/hypointense to white matter on postoperative CT/MRI separating the resection cavity from the ventricular lumen in all cases. In no case did early CCT/MRI or follow-up MRI reveal wafer material within the ventricular system. In no case did signs of obstructive hydrocephalus occur.

Conclusion

Sealing of the ventricular system using a fibrinogen-coated collagen fleece effectively separates the resection cavity from the ventricular system and allows implantation of BCNU wafers into the resection cavity. No morphological evidence for wafer material dislocation into the ventricular system or obstruction of CSF pathways was found in nine patients who received 41 follow-up MRI over 10.4 months of follow-up.

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Title: Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study
Authors: Hans Christoph Bock
Joseph Cohnen
Naureen Keric
Sven Rainer Kantelhardt
Alf Giese
Publication date: 01-03-2011
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 3/2011
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-010-0923-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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