Top

Published in:

01-07-2010 | Case Report

Multiple cranial neuropathy as the initial presentation of metastatic prostate adenocarcinoma: case report and review of literature

Authors: Angelos G. Kolias, Christopher Derham, Kshitij Mankad, Harutomo Hasegawa, Roddy O’Kane, Azzam Ismail, Nicholas I. Phillips

Published in: Acta Neurochirurgica | Issue 7/2010

Abstract

The skull base is an atypical metastatic site for prostate carcinoma. It is usually encountered late in the disease process in patients with known advanced disease. However, skull base involvement causing cranial nerve palsies may rarely be the presenting sign of prostate carcinoma. Such patients may present to a number of specialties including neurosurgery and can pose a diagnostic challenge in the absence of lower urinary tract symptoms. Here, we describe an unusual case of prostate adenocarcinoma presenting as a central skull base tumour with multiple cranial neuropathy.

Long MA, Husband JE (1999) Features of unusual metastases from prostate cancer. Br J Radiol 72(862):933–941PubMed

McDermott RS, Anderson PR, Greenberg RE, Milestone BN, Hudes GR (2004) Cranial nerve deficits in patients with metastatic prostate carcinoma: clinical features and treatment outcomes. Cancer 101(7):1639–1643CrossRefPubMed

Ransom DT, Dinapoli RP, Richardson RL (1990) Cranial nerve lesions due to base of the skull metastases in prostate carcinoma. Cancer 65(3):586–589CrossRefPubMed

Jansen BPW, Sillevis Smitt PAE (2002) Skull and dural metastases. In: Schiff D, Wen PY (eds) Cancer neurology in clinical practice. Humana, New Jersey, pp 87–92CrossRef

Laigle-Donadey F, Taillibert S, Martin-Duverneuil N, Hildebrand J, Delattre JY (2005) Skull base metastases. J Neurooncol 75(1):63–69CrossRefPubMed

Greenberg HS, Deck MD, Vikram B, Chu FC, Posner JB (1981) Metastasis to the base of the skull: clinical findings in 43 patients. Neurology 31(5):530–537PubMed

Capobianco DJ, Brazis PW, Rubino FA, Dalton JN (2002) Occipital condyle syndrome. Headache 42(2):142–146CrossRefPubMed

Gupta SR, Zdonczyk DE, Rubino FA (1990) Cranial neuropathy in systemic malignancy in a VA population. Neurology 40(6):997–999PubMed

O'Sullivan JM, Norman AR, McNair H, Dearnaley DP (2004) Cranial nerve palsies in metastatic prostate cancer—results of base of skull radiotherapy. Radiother Oncol 70(1):87–90CrossRefPubMed

10.

Seymore CH, Peeples WJ (1988) Cranial nerve involvement with carcinoma of prostate. Urology 31(3):211–213CrossRefPubMed

11.

Svare A, Fossa SD, Heier MS (1988) Cranial nerve dysfunction in metastatic cancer of the prostate. Br J Urol 61(5):441–444CrossRefPubMed

12.

Malloy KA (2007) Prostate cancer metastasis to clivus causing cranial nerve VI palsy. Optometry 78(2):55–62PubMed

13.

O'Boyle JE, Gardner TA, Oliva A, Enzenauer RW (1992) Sixth nerve palsy as the initial presenting sign of metastatic prostate cancer. A case report and review of the literature. J Clin Neuroophthalmol 12(3):149–153PubMed

14.

McAvoy CE, Kamalarajab S, Best R, Rankin S, Bryars J, Nelson K (2002) Bilateral third and unilateral sixth nerve palsies as early presenting signs of metastatic prostatic carcinoma. Eye 16(6):749–753CrossRefPubMed

15.

Hemmings KW (1990) Isolated hypoglossal nerve palsy as a presenting feature of prostatic carcinoma—a case report. Br J Oral Maxillofac Surg 28(2):125–127CrossRefPubMed

16.

Mitchell DM, Wynne CJ, Cowan I (2008) Multiple cranial nerve palsies as the presenting features of prostate carcinoma. J Med Imaging Radiat Oncol 52(2):194–196CrossRefPubMed

17.

Jansen BP, Pillay M, de Bruin HG, van den Bent MJ, Vecht CJ, Sillevis Smitt PA (1997) 99mTc-SPECT in the diagnosis of skull base metastasis. Neurology 48(5):1326–1330PubMed

18.

Graham J, Baker M, Macbeth F, Titshall V (2008) Diagnosis and treatment of prostate cancer: summary of NICE guidance. BMJ 336(7644):610–612CrossRefPubMed

19.

Hanbali F, DeMonte F (2004) Metastatic tumors of the skull base. In: Sawaya R (ed) Intracranial metastases: current management strategies. Blackwell, Massachusetts, pp 415–429CrossRef

20.

Goldbrunner R (2005) Tumors of the skull. In: Tonn JC, Westphal M, Rutka JT, Grossman SA (eds) Neuro-oncology of CNS tumors. Springer, Heidelberg, pp 73–80

Title: Multiple cranial neuropathy as the initial presentation of metastatic prostate adenocarcinoma: case report and review of literature
Authors: Angelos G. Kolias
Christopher Derham
Kshitij Mankad
Harutomo Hasegawa
Roddy O’Kane
Azzam Ismail
Nicholas I. Phillips
Publication date: 01-07-2010
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 7/2010
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-010-0630-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Multiple cranial neuropathy as the initial presentation of metastatic prostate adenocarcinoma: case report and review of literature

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 7/2010

The transclival endoscopic endonasal approach (EEA) for prepontine neuroenteric cysts: report of two cases

Lectin-like oxidized low-density lipoprotein receptor 1 and matrix metalloproteinase expression in ruptured and unruptured multiple dissections of distal middle cerebral artery: case report

Accreditation of Neurosurgical Training Programmes in Europe: Report of JRAAC

The retrogasserian zone versus dorsal root entry zone: comparison of two targeting techniques of gamma knife radiosurgery for trigeminal neuralgia

Magnetic resonance angiography, digital subtraction angiography and Doppler ultrasonography in detection of carotid artery stenosis: a comparison with findings from histological specimens

Surgery for cervical disc disease. Why go for the worst solution?