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01-07-2009 | Short Illustrated Review

Gliosarcoma with osteosarcomatous features: a short illustrated review

Authors: Slim Charfi, Lobna Ayadi, Abdelmajid Khabir, Emna Daoud, Rim Kallel, Oussama Kharrat, Zeineb Mnif, Zaher Boudawara, Saloua Makni, Tahya Boudawara

Published in: Acta Neurochirurgica | Issue 7/2009

Abstract

Introduction

Gliosarcoma is a rare, malignant, biphasic brain tumor formed by both glioblastoma and sarcomatous components. Various lines of differentiation are described in the latter component, but most commonly fibrosarcomatous and pleomophic sarcoma are present. Osteosarcomatous features are exceedingly rare.

Objective

We report a case of gliosarcoma with osteosarcomatous features in a 33-year-old woman.

Methods

Histologically, the sarcomatous portion displayed a typical pattern of fibrosarcoma associated with areas of osteoid formation.

Results and conclusion

Immunohistochemical glial fibrillary acid protein (GFAP) expression was seen only in the glioblastoma portion. Clinicopathological characteristics and radiological data of this rare condition were reviewed. Possible differential diagnoses and potential histogenesis were also discussed.

Actor B, Cobbers JM, Büschges R, Wolter M, Knobbe CB, Lichter P, Reifenberger G, Weber RG (2002) Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components. Genes Chromosomes Cancer 34:416–427PubMedCrossRef

Alatakis S, Stuckey S, Siu K, McLean C (2004) Gliosarcoma with osteosarcomatous differentiation: review of radiological and pathological features. J Clin Neurosci 11:650–656PubMedCrossRef

Barresi V, Cerasoli S, Morigi F, Cremonini AM, Volpini M, Tuccari G (2006) Gliosarcoma with features of osteoblastic osteosarcoma: a review. Arch Pathol Lab Med 130:1208–1211PubMed

Feigin IH, Gross SW (1955) Sarcoma arising in glioblastoma of the brain. Am J Pathol 31:633–653PubMed

Hayashi K, Ohara N, Jeon HJ, Akagi S, Takahashi K, Akagi T, Namba S (1993) Gliosarcoma with features of chondroblastic osteosarcoma. Cancer 72:850–855PubMedCrossRef

Kepes JJ, Rubinstein LJ, Chiang H (1984) The role of astrocytes in the formation of cartilage in gliomas. An immunohistochemical study of four cases. Am J Pathol 117:471–483PubMed

Li N, Qian Y, Ma H (1996) A clinical and pathological study of gliosarcoma. Zhonghua Bing Li Xue Za Zhi 25:129–131PubMed

Lieberman KA, Fuller CE, Caruso RD, Schelper RL (2001) Postradiation gliosarcoma with osteosarcomatous components. Neuroradiology 43:555–558PubMedCrossRef

Malone JC, Brown KZ, Parker JC Jr (1999) Gliosarcoma containing malignant fibrohistiocytic, osseous, and chondroid elements. Arch Pathol Lab Med 123:358–360PubMed

10.

Mathews T, Moossy J (1974) Gliomas containing bone and cartilage. J Neuropathol Exp Neurol 33:456–471PubMedCrossRef

11.

Meis JM, Martz KL, Nelson JS (1991) Mixed glioblastoma multiforme and sarcoma. A clinicopathologic study of 26 radiation therapy oncology group cases. Cancer 67:2342–2349PubMedCrossRef

12.

Mekni A, Ben Haha Bellil S, Bouraoui S, El Ouertani L, Ayadi A, Bellil K, Kchir N, Zitouna M, Haouet S (2003) An unusual tumor of the central nervous system. Ann Pathol 23:185–186PubMed

13.

Ohgaki H, Biernat W, Reis R, Hegi M, Kleihues P (2000) Gliosarcoma. In: Kleihues P, Cavenee WK (eds) World Health Organization classification of tumours. Pathology and Genetics: tumours of the nervous system. IARC Press, Lyon, pp 84–86

14.

Ozolek JA, Finkelstein SD, Couce ME (2004) Gliosarcoma with epithelial differentiation: immunohistochemical and molecular characterization. A case report and review of the literature. Mod Pathol 17:739–745PubMedCrossRef

15.

Paulus W, Bayas A, Ott G, Roggendorf W (1994) Interphase cytogenetics of glioblastoma and gliosarcoma. Acta Neuropathol 88:420–425PubMedCrossRef

16.

Paulus W, Jellinger K (1993) Mixed glioblastoma and malignant mesenchymoma, a variety of gliosarcoma. Histopathology 22:277–279PubMedCrossRef

17.

Perry JR, Ang LC, Bilbao JM, Muller PJ (1995) Clinicopathologic features of primary and postirradiation cerebral gliosarcoma. Cancer 75:2910–2918PubMedCrossRef

18.

Reis RM, Könü-Lebleblicioglu D, Lopes JM, Kleihues P, Ohgaki H (2000) Genetic profile of gliosarcomas. Am J Pathol 156:425–432PubMed

19.

Sarmiento J, Ferrer I, Pons L, Ferrer E (1979) Cerebral mixed tumour: osteocondrosarcoma-glioblastoma multiforme. Acta Neurochir (Wien) 50:335–341CrossRef

20.

Schittenhelm J, Erdmann T, Maennlin S, Will BE, Beschorner R, Bornemann A, Meyermann R, Mittelbronn M (2007) Gliosarcoma with chondroid and osseous differentiation. Neuropathology 27:90–94PubMedCrossRef

21.

Tada T, Katsuyama T, Aoki T, Kobayashi S, Shigematsu H (1987) Mixed glioblastoma and sarcoma with osteoid-chondral tissue. Clin Neuropathol 6:160–163PubMed

Title: Gliosarcoma with osteosarcomatous features: a short illustrated review
Authors: Slim Charfi
Lobna Ayadi
Abdelmajid Khabir
Emna Daoud
Rim Kallel
Oussama Kharrat
Zeineb Mnif
Zaher Boudawara
Saloua Makni
Tahya Boudawara
Publication date: 01-07-2009
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 7/2009
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0341-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gliosarcoma with osteosarcomatous features: a short illustrated review

Abstract

Introduction

Objective

Methods

Results and conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Objective

Methods

Results and conclusion

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