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01-06-2009 | Short Illustrated Review

Cerebellar glioblastomas: pathophysiology, clinical presentation and management

Authors: Gordan Grahovac, Damir Tomac, Smiljka Lambasa, Arijana Zoric, Mario Habek

Published in: Acta Neurochirurgica | Issue 6/2009

Summary

Glioblastoma multiforme usually affects the cerebral hemispheres with the peak age of onset in the sixth or seventh decade, while cerebellar glioblastoma multiforme is a rare tumour especially in younger patients. Most result from de-differentiation from low grade astrocytoma (secondary glioblastoma) or can develop de novo (primary glioblastoma). Primary glioblastomas develop in older patients while secondary glioblastomas develop in younger patients and contain TP53 mutations as the earliest detectable change. We report a 28 year old patient with primary multi-focal cerebellar glioblastoma multiforme and review the pathophisiology, clinical presentation, diagnosis and treatment of cerebellar glioblastomas.

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Title: Cerebellar glioblastomas: pathophysiology, clinical presentation and management
Authors: Gordan Grahovac
Damir Tomac
Smiljka Lambasa
Arijana Zoric
Mario Habek
Publication date: 01-06-2009
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 6/2009
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0286-5

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Cerebellar glioblastomas: pathophysiology, clinical presentation and management

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