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01-10-2008 | Clinical Article

Comparison of navigated 3D ultrasound findings with histopathology in subsequent phases of glioblastoma resection

Authors: Ola Morten Rygh, Tormod Selbekk, Sverre Helge Torp, Stian Lydersen, Toril Anita Nagelhus Hernes, Geirmund Unsgaard

Published in: Acta Neurochirurgica | Issue 10/2008

Abstract

Objective

The purpose of the study was to compare the ability of navigated 3D ultrasound to distinguish tumour and normal brain tissue at the tumour border zone in subsequent phases of resection.

Materials and methods

Biopsies were sampled in the tumour border zone as seen in the US images before and during surgery. After resection, biopsies were sampled in the resection cavity wall. Histopathology was compared with the surgeon’s image findings.

Results

Before resection, the tumour border was delineated by ultrasound with high specificity and sensitivity (both 95%). During resection, ultrasound had acceptable sensitivity (87%), but poor specificity (42%), due to biopsies falsely classified as tumour by the surgeon. After resection, sensitivity was poor (26%), due to tumour or infiltrated tissue in several biopsies deemed normal by ultrasound, but the specificity was acceptable (88%).

Conclusions

Our study shows that although glioblastomas are well delineated prior to resection, there seem to be overestimation of tumour tissue during resection. After resection tumour remnants and infiltrated brain tissue in the resection cavity wall may be undetected. We believe that the benefits of intraoperative ultrasound outweigh the shortcomings, but users of intraoperative ultrasound should keep the limitations shown in our study in mind.

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Title: Comparison of navigated 3D ultrasound findings with histopathology in subsequent phases of glioblastoma resection
Authors: Ola Morten Rygh
Tormod Selbekk
Sverre Helge Torp
Stian Lydersen
Toril Anita Nagelhus Hernes
Geirmund Unsgaard
Publication date: 01-10-2008
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 10/2008
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-008-0017-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of navigated 3D ultrasound findings with histopathology in subsequent phases of glioblastoma resection

Abstract

Objective

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

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