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Surgery Today
Published in: Surgery Today 6/2017

01-06-2017 | Review Article

Subsequent biliary cancer originating from remnant intrapancreatic bile ducts after cyst excision: a literature review

Authors: Yoshiaki Mizuguchi, Yoshiharu Nakamura, Eiji Uchida

Published in: Surgery Today | Issue 6/2017

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Abstract

Purpose

There are sporadic reports of cancers developing in the remnant intrapancreatic bile duct tissues of patients with a history of primary choledochal cyst excision. The objective of this review is to study the clinical course of patients who develop subsequent biliary cancer originating from the remnant intrapancreatic bile ducts after cyst excision.

Methods

We describe a total of 17 cases (male:female 5:11; mean age 39.5 years), including the present case, from a review of the medical literature.

Results

Type I, type Iva, and unknown-type choledochal cysts according to the Todani classification were reported in nine, five, and three cases, respectively. The mean time to the development of subsequent cancer was 13.6 years. With the exception of one case, all of the cases (seven/eight cases) had elevated levels of serum CEA and/or CA19-9. Computed tomography was useful for detecting tumors (9/10 cases). Despite aggressive treatment, the cumulative survival rate after treatment was approximately 40 % at 1 year, with a mean survival duration of 12 months.

Conclusion

Cancer may develop up to 10 years after choledochal cyst excision, indicating the need for life-long follow-up in this patient population.
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Metadata
Title
Subsequent biliary cancer originating from remnant intrapancreatic bile ducts after cyst excision: a literature review
Authors
Yoshiaki Mizuguchi
Yoshiharu Nakamura
Eiji Uchida
Publication date
01-06-2017
Publisher
Springer Japan
Published in
Surgery Today / Issue 6/2017
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-016-1366-9

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