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Surgery Today
Published in: Surgery Today 11/2016

01-11-2016 | Original Article

A non-smooth tumor margin on preoperative imaging predicts microvascular invasion of hepatocellular carcinoma

Authors: Tsung-Han Wu, Etsuro Hatano, Kenya Yamanaka, Satoru Seo, Kojiro Taura, Kentaro Yasuchika, Yasuhiro Fujimoto, Takashi Nitta, Masaki Mizumoto, Akira Mori, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto

Published in: Surgery Today | Issue 11/2016

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Abstract

Purposes

Microvascular invasion (mVI) is known to be a risk factor of hepatocellular carcinoma (HCC) recurrence. Several factors such as the tumor grade, tumor size, tumor margin status on imaging studies, fluorine-18 fluorodeoxyglucose-positron emission tomography (18F-FDG-PET) results, and tumor markers have been proposed to predict mVI of HCC. However, the values of these factors have not yet been validated.

Methods

Among the patients evaluated using enhanced CT/MRI, 18F-FDG-PET, and tumor markers prior to hepatectomy from 2007 to 2012, 79 HCC patients without apparent macrovascular invasion in preoperative imaging were enrolled in this study. The image tumor margin status (smooth/non-smooth), 18F-FDG-PET, and tumor markers, which were previously described as predictors for mVI, were evaluated.

Results

Fifteen patients had mVI (mVI+ group) and 64 patients had no evidence of mVI (mVI− group) on pathological examinations. A univariate analysis showed that the mVI+ group had a higher SUV and TNR (5.2 vs 3.8, p = 0.02 and 1.8 vs 1.3, p = 0.02, respectively) and a higher portion of non-smooth tumor margin (87 vs 27 %, p = 0.0001). There was no significant difference in the tumor markers. A multivariate analysis showed that non-smooth tumor margin alone could independently predict mVI (odds ratio 18.3, 95 % CI 3.27–102.6, p = 0.0009).

Conclusion

A non-smooth tumor margin on preoperative imaging predicts microvascular invasion of HCC.
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Metadata
Title
A non-smooth tumor margin on preoperative imaging predicts microvascular invasion of hepatocellular carcinoma
Authors
Tsung-Han Wu
Etsuro Hatano
Kenya Yamanaka
Satoru Seo
Kojiro Taura
Kentaro Yasuchika
Yasuhiro Fujimoto
Takashi Nitta
Masaki Mizumoto
Akira Mori
Hideaki Okajima
Toshimi Kaido
Shinji Uemoto
Publication date
01-11-2016
Publisher
Springer Japan
Published in
Surgery Today / Issue 11/2016
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-016-1320-x

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