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01-05-2014 | Review Article

Colorectal cancer and hypercoagulability

Authors: Kazushige Kawai, Toshiaki Watanabe

Published in: Surgery Today | Issue 5/2014

Abstract

Since the first report of the spontaneous appearance of venous thrombophlebitis as a sign of visceral cancer by Trousseau in 1865, many other studies have documented the existence of cancer-associated coagulation disorders. In this review, we describe the hypercoagulable state associated with colorectal cancer, from three perspectives: first, the incidence, risk factors and prevention of clinically symptomatic thromboembolic conditions associated with cancer, such as venous thromboembolism and arterial thrombosis; second, the association between hypercoagulable conditions, such as thrombocytosis, hyperfibrinogenemia, or d-dimer elevation, and the clinical progression and poor prognosis of cancer patients; third, the experimental approach to elucidate the role of various coagulation-related factors in the process of cancer progression, focusing specifically on the role of platelets and tissue factors.

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Title: Colorectal cancer and hypercoagulability
Authors: Kazushige Kawai
Toshiaki Watanabe
Publication date: 01-05-2014
Publisher: Springer Japan
Published in: Surgery Today / Issue 5/2014
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-013-0606-5

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Colorectal cancer and hypercoagulability

Abstract

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Abstract

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