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01-02-2014 | Original Article

A new hepatectomy-induced postoperative adhesion model in rats, and evaluation of the efficacy of anti-adhesion materials

Authors: Atsushi Shimizu, Takashi Suhara, Taichi Ito, Kiyohiko Omichi, Katsutoshi Naruse, Kiyoshi Hasegawa, Norihiro Kokudo

Published in: Surgery Today | Issue 2/2014

Abstract

Purpose

Repeated hepatic resections are not uncommon during the surgical management of liver tumors. Postoperative adhesions induced by hepatectomies can have a significant negative impact on subsequent surgeries. We recently developed a new hepatectomy-induced postoperative adhesion animal model to evaluate the anti-adhesion efficacy of commercially available sheet materials (Seprafilm^® and Interceed^®) and the recently reported hyaluronan-based in situ cross-linkable hydrogels.

Methods

The median lobe (ML) and the left lateral lobe (LLL) of the liver (approximately 70 % of the total liver) of 43 male Sprague–Dawley rats were resected based on the classical procedure; anti-adhesion materials were then applied. A relaparotomy was performed 1 week later to evaluate the adhesions and histopathological findings.

Results

The rats without the application of anti-adhesion materials (n = 14) showed the most severe adhesions (grade 3) between the cut surface of the liver and the small bowel or omentum. All the barrier materials produced slight anti-adhesion effects. Adhesions between the liver surface and the diaphragm and adhesions around the hepatic hilum were less severe, but were not remarkably reduced, by the anti-adhesion materials.

Conclusion

We successfully established a new hepatectomy-induced animal adhesion model, which may be useful for the development of new anti-adhesion materials.

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Title: A new hepatectomy-induced postoperative adhesion model in rats, and evaluation of the efficacy of anti-adhesion materials
Authors: Atsushi Shimizu
Takashi Suhara
Taichi Ito
Kiyohiko Omichi
Katsutoshi Naruse
Kiyoshi Hasegawa
Norihiro Kokudo
Publication date: 01-02-2014
Publisher: Springer Japan
Published in: Surgery Today / Issue 2/2014
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-013-0530-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A new hepatectomy-induced postoperative adhesion model in rats, and evaluation of the efficacy of anti-adhesion materials

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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