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01-02-2012 | Original Article

Clinical impact of lymph node dissection in surgery for peripheral-type intrahepatic cholangiocarcinoma

Authors: Yuji Morine, Mitsuo Shimada, Tohru Utsunomiya, Satoru Imura, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, Hidenori Miyake

Published in: Surgery Today | Issue 2/2012

Abstract

Purpose

To investigate the prognostic factors of peripheral-type intrahepatic cholangiocarcinoma (PP-IHCC) and evaluate the surgical outcomes according to surgical strategy alterations.

Methods

Twenty-two patients were divided into two groups according to the surgical strategy: an extended surgery group (Ex group: n = 10), composed of those who underwent hepatic lobectomy combined with lymph node (LN) dissection and bile duct resection; and a customized surgery group (Cx group: n = 12), composed of those who underwent hepatectomy and bile duct resection according to tumor spread. LN dissection was not performed in patients without LN metastasis.

Results

Multivariate analysis revealed that R2 resection, LN metastasis, and intrahepatic metastasis were independent prognostic factors. LN dissection was significantly infrequent in the Cx group. Survival after curative resection was similar in the two groups (3-year survival: 42.9 vs. 57.1%). Liver metastasis was the most frequent primary recurrence, occurring in more than 80% of patients from both groups.

Conclusions

Curative surgery might improve the prognosis of patients with PP-IHCC, but routine LN dissection is not recommended, particularly for patients without LN metastasis. Surgery alone, including LN dissection, cannot control this type of tumor, and additional treatment should be given.

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Title: Clinical impact of lymph node dissection in surgery for peripheral-type intrahepatic cholangiocarcinoma
Authors: Yuji Morine
Mitsuo Shimada
Tohru Utsunomiya
Satoru Imura
Tetsuya Ikemoto
Hiroki Mori
Jun Hanaoka
Mami Kanamoto
Hidenori Miyake
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Surgery Today / Issue 2/2012
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-011-0057-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical impact of lymph node dissection in surgery for peripheral-type intrahepatic cholangiocarcinoma

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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