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01-08-2017 | Original Article

Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis

Authors: Shoji Seki, Norikazu Hirano, Yoshiharu Kawaguchi, Masato Nakano, Taketoshi Yasuda, Kayo Suzuki, Kenta Watanabe, Hiroto Makino, Masahiko Kanamori, Tomoatsu Kimura

Published in: European Spine Journal | Issue 8/2017

Abstract

Purpose

Complications of adult spinal deformity surgery are problematic in osteoporotic individuals. We compared outcomes between Japanese patients treated perioperatively with teriparatide vs. low-dose bisphosphonates.

Methods

Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion. Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age. Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.

Results

Adjacent vertebral fractures and implant failure, fusion failure, and poor pain and ODI outcomes were significantly more common in the bisphosphonates group than the teriparatide group.

Conclusions

Perioperative administration of teriparatide is more effective than that of low-dose bisphosphonates in preventing complications and maintaining fusion rates in osteoporotic Japanese females with spinal deformities undergoing surgery.

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Title: Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis
Authors: Shoji Seki
Norikazu Hirano
Yoshiharu Kawaguchi
Masato Nakano
Taketoshi Yasuda
Kayo Suzuki
Kenta Watanabe
Hiroto Makino
Masahiko Kanamori
Tomoatsu Kimura
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue 8/2017
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-017-4959-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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