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European Spine Journal

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01-03-2013 | Review article

Animal models for scoliosis research: state of the art, current concepts and future perspective applications

Authors: Jean Ouellet, Thierry Odent

Published in: European Spine Journal | Special Issue 2/2013

Abstract

Purpose

The purpose of this study was to provide the readers with a reliable source of animal models currently being utilized to perform state-of-the-art scoliotic research.

Materials and methods

A comprehensive search was undertaken to review all publications on animal models for the study of scoliosis within the database from 1946 to January 2011.

Results

The animal models have been grouped under specific headings reflecting the underlying pathophysiology behind the development of the spinal deformities produced in the animals: genetics, neuroendocrine, neuromuscular, external constraints, internal constraints with or without tissue injury, vertebral growth modulation and iatrogenic congenital malformations, in an attempt to organize and classify these multiple scoliotic animal models. As it stands, there are no animal models that mimic the human spinal anatomy with all its constraints and weaknesses, which puts it at risk of developing scoliosis. What we do have are a multitude of models, which produce spinal deformities that come close to the idiopathic scoliosis deformity.

Conclusion

All these different animal models compel us to believe that the clinical phenotype of what we call idiopathic scoliosis may well be caused by a variety of different underlying pathologies.

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Title: Animal models for scoliosis research: state of the art, current concepts and future perspective applications
Authors: Jean Ouellet
Thierry Odent
Publication date: 01-03-2013
Publisher: Springer-Verlag
Published in: European Spine Journal / Issue Special Issue 2/2013
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-012-2396-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Animal models for scoliosis research: state of the art, current concepts and future perspective applications

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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