Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Spine Journal
Published in: European Spine Journal 10/2012

01-10-2012 | Original Article

Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases

Authors: Stefano Boriani, L. Amendola, S. Bandiera, C. E. Simoes, M. Alberghini, M. Di Fiore, A. Gasbarrini

Published in: European Spine Journal | Issue 10/2012

Login to get access

Abstract

Purpose

To define the role of Enneking staging system and of the consequent different treatment options on the outcome of osteoblastoma (OBL) of the spine.

Methods

A retrospective review of 51 patients with OBL of the mobile spine conducted to compare the outcomes among the different types of treatments at long term follow-up (25–229 months, av.90). These 51 patients were previously staged according to Enneking staging system and treatment selected accordingly. 10 stage two (st.2) OBLs were treated with intralesional excision and 41 stage three (st.3) OBLs were treated either by intralesional excision or en bloc resection. The intralesional excision group was divided considering the use or not of radiation therapy after surgery. The recurrence rate was compared among these groups and also considering previous open surgery (“non intact” vs. “intact”). The statistical significance was defined using the Fisher Exact test.

Results

No local recurrence occurred in the st.2 patients treated by intralesional excision. Considering the st.3 patients, 2 local recurrences out of 13 patients occurred in the en bloc resection (15.4 %) group. All occurred in “non intact” cases (67 %). In the intralesional group, 5 local recurrences out of 27 patients occurred (18 %) being none in the group that received radiation therapy after surgery. Two occurred in the “intact” (7 %) and three in the “non intact” group (75 %). Considering all patients, the difference between the recurrence rate between “intact” and “non intact” groups was statistically significant (p < 0.002).

Conclusions

Intralesional excision proved to be effective in st.2 lesions and en bloc resection in st.3. Radiotherapy seems to be an effective adjuvant treatment when en bloc resection is not feasible or requires unacceptable functional sacrifices. The first treatment significantly affects the prognosis as previously treated patients have worse prognosis.
Literature
1.
Jaffe HL (1956) Benign osteoblastoma. Bull Hosp Joint Dis 17(2):141–151PubMed
2.
Lichtenstein L (1956) Benign osteoblastoma: a category of osteoid-and bone-forming tumors other than classical osteoid osteoma, which may be mistaken for giant-cell tumor or osteogenic sarcoma. Cancer 9(5):1044–1052PubMedCrossRef
3.
Janin Y, Epstein JA, Carras R, Khan A (1981) Osteoid osteomas and osteoblastomas of the spine. Neurosurgery 8(1):31–38PubMedCrossRef
4.
Unni KK (1996) Benign Osteoblastoma. Dahlin’s Bone Tumors. General Aspects and Data on 11,087 Cases, 5th edn. Lippincott-Raven, Philadelphia, pp 131–142
5.
Burn SC, Ansorge O, Zeller R, Drake JM (2009) Management of osteoblastoma and osteoid osteoma of the spine in childhood. J Neurosurg Pediatr 4(5):434–438PubMedCrossRef
6.
Saccomanni B (2009) Osteoid osteoma and osteoblastoma of the spine: a review of the literature. Curr Rev Musculoskelet Med 2(1):65–67PubMedCrossRef
7.
Zileli M, Cagli S, Basdemir G, Ersahin Y (2003) Osteoid osteomas and osteoblastomas of the spine. Neurosurg Focus 15(5):E5PubMed
8.
Dahlin DC, Johnson EW (1954) Giant osteoid osteoma. J Bone Joint Surg 36-A(3):559–572PubMed
9.
Jaffe HL (1935) Osteoid osteoma: a benign osteoblastic tumor composed of osteoid and atypical bone. Arch Orthop Trauma Surg 31:709–728
10.
Marsh BW, Bonfiglio M, Brady LP, Enneking WF (1975) Benign osteoblastoma: range of manifestations. J Bone Joint Surg Am 57(1):1–9PubMed
11.
Boriani S, Capanna R, Donati D, Levine A, Picci P, Savini R (1992) Osteoblastoma of the spine. Clin Orthop Relat Res 278:37–45PubMed
12.
Enneking WF (1986) A system of staging musculoskeletal neoplasms. Clin Orthop Relat Res 204:9–24PubMed
13.
Chan P, Boriani S, Fourney DR et al (2009) An assessment of the reliability of the Enneking and Weinstein-Boriani-Biagini classifications for staging of primary spinal tumors by the spine oncology study group. Spine 34(4):384–391PubMedCrossRef
14.
Boriani S, Weinstein JN, Biagini R (1997) Primary bone tumors of the spine terminology and surgical staging. Spine 22(9):1036–1044PubMedCrossRef
15.
Frankel HL (1969) Ascending cord lesion in the early stages following spinal injury. Paraplegia 7(2):111–118PubMedCrossRef
16.
Harrop JS, Schmidt MH, Boriani S et al (2009) Agressive “benign” primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor. Spine 34(22 Suppl):S39–S47PubMedCrossRef
17.
Collignon JC, Kalangu K, Flandroy P (1988) Benign osteoblastoma of the spine apropos of 4 cases with a case of spontaneous recovery. Neurochirurgie 34(4):262–270PubMed
18.
Saifuddin A, White J, Sherazi Z et al (1998) Osteoid osteoma and osteoblastoma of the spine factors associated with the presence of scoliosis. Spine 23(1):47–53PubMedCrossRef
19.
Della Rocca C, Huvos AG (1996) Osteoblastoma: varied histological presentations with a benign clinical course an analysis of 55 cases. Am J Surg Pathol 20:841–850PubMedCrossRef
20.
Schajowicz F, Lemos C (1970) Osteoid osteoma and osteoblastoma closely related entities of osteoblastic derivation. Acta Orthop Scand 41(3):272–291PubMedCrossRef
21.
Cerase A, Priolo F (1998) Skeletal benign bone-forming lesions. Europ J Radiol 27(Suppl 1):S91–S97CrossRef
22.
Bertoni F, Unni KK, McLeod RA, Dahlin DC (1985) Osteosarcoma resembling osteoblastoma. Cancer 55(2):416–426PubMedCrossRef
23.
Dorfman HD, Weiss SW (1984) Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcoma. Semin Diagn Pathol 1(3):215–234PubMed
24.
Sung HW, Liu CC (1979) Can osteoid osteoma become osteoblastoma? a case report. Arch Orthop Trauma Surg 95(3):217–219PubMedCrossRef
25.
Tonai M, Campbell CJ, Ahn GH, Schiller AL, Mankin HJ (1982) Osteoblastoma: classification and report of 16 patients. Clin Orthop Relat Res 167:222–235PubMed
Metadata
Title
Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases
Authors
Stefano Boriani
L. Amendola
S. Bandiera
C. E. Simoes
M. Alberghini
M. Di Fiore
A. Gasbarrini
Publication date
01-10-2012
Publisher
Springer-Verlag
Published in
European Spine Journal / Issue 10/2012
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-012-2395-8

Other articles of this Issue 10/2012

European Spine Journal 10/2012 Go to the issue

Original Article

Loading rate patterns in scoliotic children during gait: the impact of the schoolbag carriage and the importance of its position

Review Article

The genetic epidemiology of idiopathic scoliosis

Original Article

Neurological recovery in patients of old healed tubercular rigid kyphosis with myelopathy treated with transpedicular decancellation osteotomy

Original Article

Reversing the concept: correction of adolescent idiopathic scoliosis using the convex rod de-rotation maneuver

Original Article

Intracranial hemorrhage following lumbar spine surgery

Original Article

Increase in spinal longitudinal length by correction surgery for adolescent idiopathic scoliosis