Skip to main content
Top
Published in: European Spine Journal 1/2004

01-02-2004 | Review

Prevention of venous thromboembolism in spinal surgery

Authors: S. Brambilla, C. Ruosi, G. A. La Maida, S. Caserta

Published in: European Spine Journal | Issue 1/2004

Login to get access

Abstract

Deep vein thrombosis (DVT), and its most feared complication, pulmonary embolism (PE), still have a high incidence with high risk for patients’ health. Proven prophylactic measures are available but are generally underused, and DVT is still considered the most common cause of preventable death among hospitalized patients. The rationale for prophylaxis of venous thromboembolism is based on the clinically silent nature of the disease, the relatively high prevalence among hospitalized patients and the potentially tragic consequences of a missed diagnosis. During the last 15–20 years, spine surgery has changed radically, developing into a well-defined area of specialist surgery, and some attention is now being given to DVT events in spine surgery. The incidence of DVT during spine surgery is not documented in the literature, because only case reports or retrospective studies are reported. It would therefore be very helpful to initiate a multicenter study in order to understand this problem better and to develop, if possible, some guidelines on prophylactic measures in spine surgery. In doing so, we need to consider each patient’s pattern, any risk factors and every kind of surgical technique related to DVT, in order to improve the outcome of the patient and to reduce any medicolegal problems that could arise from a thrombotic complication or an epidural hematoma, with its high potential for irreversible consequences.
Literature
1.
go back to reference Agnelli G (1999) Prevention of venous thromboembolism after neurosurgery. Thromb Haemost 82:925–930PubMed Agnelli G (1999) Prevention of venous thromboembolism after neurosurgery. Thromb Haemost 82:925–930PubMed
2.
3.
go back to reference Agnelli G, Piovella F, Buoncristiani P, Severi P, Pini M, D’Angelo A, Beltrametti C, Damiani M, Andrioli GC, Pugliese R, Iorio A, Brambilla G (1998) Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery. N Engl J Med 339:80–85 Agnelli G, Piovella F, Buoncristiani P, Severi P, Pini M, D’Angelo A, Beltrametti C, Damiani M, Andrioli GC, Pugliese R, Iorio A, Brambilla G (1998) Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery. N Engl J Med 339:80–85
4.
go back to reference Agnelli G, Mancini GB, Biagini D (2000) The rationale for long-term prophylaxis of venous thromboembolism. Orthopedics 23 [Suppl 6]:643–646 Agnelli G, Mancini GB, Biagini D (2000) The rationale for long-term prophylaxis of venous thromboembolism. Orthopedics 23 [Suppl 6]:643–646
5.
go back to reference Andreshak TG, An HS, Hall J, Stein B (1997) Lumbar spine surgery in the obese patient. J Spinal Disord 10:376–379PubMed Andreshak TG, An HS, Hall J, Stein B (1997) Lumbar spine surgery in the obese patient. J Spinal Disord 10:376–379PubMed
6.
go back to reference Ansari S, Warwick D, Ackroid CE (1997) Incidence of fatal pulmonary embolism after 1390 knee arthroplasties without routine prophylactic anticoagulation, except in high-risk cases. J Arthroplasty 12:599–602PubMed Ansari S, Warwick D, Ackroid CE (1997) Incidence of fatal pulmonary embolism after 1390 knee arthroplasties without routine prophylactic anticoagulation, except in high-risk cases. J Arthroplasty 12:599–602PubMed
7.
go back to reference Arai Y, Shitoto K, Muta T, Kurosawa H (1999) Pulmonary thromboembolism after spinal instrumentation surgery. J Orthop Sci 4:380–383CrossRefPubMed Arai Y, Shitoto K, Muta T, Kurosawa H (1999) Pulmonary thromboembolism after spinal instrumentation surgery. J Orthop Sci 4:380–383CrossRefPubMed
8.
go back to reference Arcelus JI, Caprini JA, Reyna JJ (2000) Finding the right fit: effective thrombosis risk stratification in orthopedic patients. Orthopedics 23 [Suppl 6]:633–638 Arcelus JI, Caprini JA, Reyna JJ (2000) Finding the right fit: effective thrombosis risk stratification in orthopedic patients. Orthopedics 23 [Suppl 6]:633–638
9.
go back to reference Asano H, Matsubara M, Suzuki K, Morita S, Shiinomiya K (2001) Prevention of pulmonary embolism by a foot sole pump. J Bone Joint Surg Br 83:1130–1132CrossRefPubMed Asano H, Matsubara M, Suzuki K, Morita S, Shiinomiya K (2001) Prevention of pulmonary embolism by a foot sole pump. J Bone Joint Surg Br 83:1130–1132CrossRefPubMed
10.
go back to reference Axelrod DA, Wakefield TW (2001) Future directions in antithrombotic therapy: emphasis on venous thromboembolism. J Am Coll Surg 192:641–651CrossRefPubMed Axelrod DA, Wakefield TW (2001) Future directions in antithrombotic therapy: emphasis on venous thromboembolism. J Am Coll Surg 192:641–651CrossRefPubMed
11.
go back to reference Benko T, Cooke EA, McNally MA, Mollan RAB (2001) Graduated compression stockings. Knee length or thigh length? Clin Orthop 383:197–203PubMed Benko T, Cooke EA, McNally MA, Mollan RAB (2001) Graduated compression stockings. Knee length or thigh length? Clin Orthop 383:197–203PubMed
12.
go back to reference Benz RJ, Ibrahim ZG, Afshar P, Garfin SR (2001) Predicting complications in elderly patients undergoing lumbar decompression. Clin Orthop 384:116–121PubMed Benz RJ, Ibrahim ZG, Afshar P, Garfin SR (2001) Predicting complications in elderly patients undergoing lumbar decompression. Clin Orthop 384:116–121PubMed
13.
go back to reference Bostrom S, Holmgren E, Jonsson O, Lindberg S, Lindstrom B, Winso L, Zachrisson B (1986) Post-operative thromboembolism in neurosurgery. A study on the prophylactic effect of calf muscle stimulations plus Dextran compared to low-dose heparin. Acta Neurochir 80:83–89 Bostrom S, Holmgren E, Jonsson O, Lindberg S, Lindstrom B, Winso L, Zachrisson B (1986) Post-operative thromboembolism in neurosurgery. A study on the prophylactic effect of calf muscle stimulations plus Dextran compared to low-dose heparin. Acta Neurochir 80:83–89
14.
go back to reference Brown CA, Eismont FJ (1998) Complications in spinal fusion. Orthop Clin North Am 29:679–699PubMed Brown CA, Eismont FJ (1998) Complications in spinal fusion. Orthop Clin North Am 29:679–699PubMed
15.
go back to reference Buehler KO, D’Lima DD, Petersilge WJ (1999) Late deep venous thrombosis and delayed weightbearing after total hip arthroplasty. Clin Orthop 361:123–130 Buehler KO, D’Lima DD, Petersilge WJ (1999) Late deep venous thrombosis and delayed weightbearing after total hip arthroplasty. Clin Orthop 361:123–130
16.
go back to reference Cain JE, Major MR, Lauerman WC, West JL, Wood KB, Fueredi GA (1995) The morbidity of heparin therapy after development of pulmonary embolus in patients undergoing thoracolumbar or lumbar spinal fusion. Spine 20:1600–1603PubMed Cain JE, Major MR, Lauerman WC, West JL, Wood KB, Fueredi GA (1995) The morbidity of heparin therapy after development of pulmonary embolus in patients undergoing thoracolumbar or lumbar spinal fusion. Spine 20:1600–1603PubMed
17.
go back to reference Catre MG (1997) Anticoagulation in spinal surgery. A critical review of the literature. Can J Surg 40:413–419PubMed Catre MG (1997) Anticoagulation in spinal surgery. A critical review of the literature. Can J Surg 40:413–419PubMed
18.
go back to reference Chasan-Taber L, Stampfer MJ (1998) Epidemiology of oral contraceptives and cardiovascular disease. Ann Intern Med 128:467–477PubMed Chasan-Taber L, Stampfer MJ (1998) Epidemiology of oral contraceptives and cardiovascular disease. Ann Intern Med 128:467–477PubMed
19.
go back to reference Clagett GP, Anderson FA, Levine MN, Salzman EW, Wheeler HB (1992) Prevention of venous thromboembolism. Chest [Suppl] 102:391–407 Clagett GP, Anderson FA, Levine MN, Salzman EW, Wheeler HB (1992) Prevention of venous thromboembolism. Chest [Suppl] 102:391–407
20.
go back to reference Clagett GP, Anderson FA, Geerts W, Heit JA, Knudson M, Lieberman JR, Merli GJ, Wheeler HB (1998) Prevention of venous thromboembolism. Chest [Suppl] 114:531–560 Clagett GP, Anderson FA, Geerts W, Heit JA, Knudson M, Lieberman JR, Merli GJ, Wheeler HB (1998) Prevention of venous thromboembolism. Chest [Suppl] 114:531–560
21.
go back to reference Collins R, Scrimgeour A, Yusuf S (1988) Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin: overview of results of randomised trials in general, orthopaedic, and urologic surgery. N Engl J Med 318:1162–1173PubMed Collins R, Scrimgeour A, Yusuf S (1988) Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin: overview of results of randomised trials in general, orthopaedic, and urologic surgery. N Engl J Med 318:1162–1173PubMed
22.
go back to reference Colwell CW (2001) Low molecular weight heparin prophylaxis in total knee arthroplasty. The answer. Clin Orthop 392:245–248PubMed Colwell CW (2001) Low molecular weight heparin prophylaxis in total knee arthroplasty. The answer. Clin Orthop 392:245–248PubMed
23.
go back to reference Comp PC, Spiro TE, Friedman RJ, Whitsett TL, Johnson GJ, Gardiner Jr GA, Landon GC, Jové M (2001) Prolonged Enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement. J Bone Joint Surg Am 83:336–345 Comp PC, Spiro TE, Friedman RJ, Whitsett TL, Johnson GJ, Gardiner Jr GA, Landon GC, Jové M (2001) Prolonged Enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement. J Bone Joint Surg Am 83:336–345
24.
go back to reference Consortium for Spinal Cord Medicine (1997) Prevention of thromboembolism in spinal cord injury. J Spinal Cord Med 20:259–283PubMed Consortium for Spinal Cord Medicine (1997) Prevention of thromboembolism in spinal cord injury. J Spinal Cord Med 20:259–283PubMed
25.
go back to reference Costantini S, Ashkenazi E, Shoshan Y, Israel Z, Umansky F (1992) Thoracic hematomyelia secondary to Coumadin anticoagulant therapy: a case report. Eur Neurol 32:109–111PubMed Costantini S, Ashkenazi E, Shoshan Y, Israel Z, Umansky F (1992) Thoracic hematomyelia secondary to Coumadin anticoagulant therapy: a case report. Eur Neurol 32:109–111PubMed
26.
go back to reference Dahl OE, Gudmundsen TE, Haukeland L (2000) Late occurring clinical deep vein thrombosis in joint-operated patients. Acta Orthop Scand 71:47–50CrossRefPubMed Dahl OE, Gudmundsen TE, Haukeland L (2000) Late occurring clinical deep vein thrombosis in joint-operated patients. Acta Orthop Scand 71:47–50CrossRefPubMed
27.
go back to reference Dahl OE, Bergqvist D, Cohen AT, Frostick SP, Hull RD (2001) Low-molecular-weight heparin as prophylaxis against thromboembolism after total hip replacement. The never-ending story? Acta Orthop Scand 72:198–204CrossRefPubMed Dahl OE, Bergqvist D, Cohen AT, Frostick SP, Hull RD (2001) Low-molecular-weight heparin as prophylaxis against thromboembolism after total hip replacement. The never-ending story? Acta Orthop Scand 72:198–204CrossRefPubMed
28.
go back to reference De Vivo MJ, Krause JS, Lammertse DP (1999) Recent trends in mortality and causes of death among persons with spinal cord injury. Arch Phys Med Rehabil 80:1411–1419PubMed De Vivo MJ, Krause JS, Lammertse DP (1999) Recent trends in mortality and causes of death among persons with spinal cord injury. Arch Phys Med Rehabil 80:1411–1419PubMed
29.
go back to reference Dearborn JT, Hu SS, Tribus CB, Bradford DS (1999) Thromboembolic complications after major thoracolumbar spine surgery. Spine 24:1471–1476CrossRefPubMed Dearborn JT, Hu SS, Tribus CB, Bradford DS (1999) Thromboembolic complications after major thoracolumbar spine surgery. Spine 24:1471–1476CrossRefPubMed
30.
go back to reference Decousus H, Marchal C, Bonnardot JP, Elias A (1992) Frequence de la maladie thromboembolique en fonction des types de chirurgie. Ann Fr Anesth Reanim 11:244–251PubMed Decousus H, Marchal C, Bonnardot JP, Elias A (1992) Frequence de la maladie thromboembolique en fonction des types de chirurgie. Ann Fr Anesth Reanim 11:244–251PubMed
31.
go back to reference Desbordes JM, Mesz M, Maissin F, Bataille B, Guenot M (1993) Etude multicentrique retrospective de la prevention des complications thromboemboliques apres chirurgie discale lombaire. Neurochirurgie 39:178–181PubMed Desbordes JM, Mesz M, Maissin F, Bataille B, Guenot M (1993) Etude multicentrique retrospective de la prevention des complications thromboemboliques apres chirurgie discale lombaire. Neurochirurgie 39:178–181PubMed
32.
go back to reference Dunn AS, Schechter C, Gotlin A, Vomvolakis D, Jacobs E, Sacks HS, Coller B (2001) Outpatient treatment of deep venous thrombosis in diverse inner-city patients. Am J Med 110:458–462CrossRefPubMed Dunn AS, Schechter C, Gotlin A, Vomvolakis D, Jacobs E, Sacks HS, Coller B (2001) Outpatient treatment of deep venous thrombosis in diverse inner-city patients. Am J Med 110:458–462CrossRefPubMed
33.
go back to reference Falanga A, Rickles FR (1999) Pathophysiology of the thrombophilic state in the cancer patient. Semin Thromb Hemost 25:239–243PubMed Falanga A, Rickles FR (1999) Pathophysiology of the thrombophilic state in the cancer patient. Semin Thromb Hemost 25:239–243PubMed
34.
go back to reference Ferree BA (1994) Deep venous thrombosis following lumbar laminotomy and laminectomy. Orthopedics 17:35–38PubMed Ferree BA (1994) Deep venous thrombosis following lumbar laminotomy and laminectomy. Orthopedics 17:35–38PubMed
35.
go back to reference Ferree BA, Wright AM (1993) Deep venous thrombosis following posterior lumbar spinal surgery. Spine 18:1079–1082PubMed Ferree BA, Wright AM (1993) Deep venous thrombosis following posterior lumbar spinal surgery. Spine 18:1079–1082PubMed
36.
go back to reference Ferree BA, Stern PJ, Jolson RS, Roberts JM, Kahn A III (1993) Deep venous thrombosis after spinal surgery. Spine 18:315–319PubMed Ferree BA, Stern PJ, Jolson RS, Roberts JM, Kahn A III (1993) Deep venous thrombosis after spinal surgery. Spine 18:315–319PubMed
37.
go back to reference Fitzgerald Jr RH, Spiro TE, Trowbridge AA, Gardiner Jr GA, Whitsett TL, O’Connell MB, Ohar JA, Young TR (2001) Prevention of venous thromboembolic disease following primary total knee arthroplasty. A randomized, multicenter, open-label, parallel-group comparison of enoxaparin and warfarin. J Bone Joint Surg Am 83:900–906 Fitzgerald Jr RH, Spiro TE, Trowbridge AA, Gardiner Jr GA, Whitsett TL, O’Connell MB, Ohar JA, Young TR (2001) Prevention of venous thromboembolic disease following primary total knee arthroplasty. A randomized, multicenter, open-label, parallel-group comparison of enoxaparin and warfarin. J Bone Joint Surg Am 83:900–906
38.
go back to reference Fujita T, Kostuik JP, Huckell CB, Sieber AN (1998) Complications of spinal fusion in adult patients more than 60 years of age. Orthop Clin North Am 29:669–678PubMed Fujita T, Kostuik JP, Huckell CB, Sieber AN (1998) Complications of spinal fusion in adult patients more than 60 years of age. Orthop Clin North Am 29:669–678PubMed
39.
go back to reference Geerts WH, Code KI, Jay RM (1994) A prospective study of VTE after major trauma. N Engl J Med 331:1601–1606CrossRefPubMed Geerts WH, Code KI, Jay RM (1994) A prospective study of VTE after major trauma. N Engl J Med 331:1601–1606CrossRefPubMed
40.
go back to reference Geerts WH, Heit JA, Clagett GP, Pineo GF, Colwell CW, Anderson FA, Wheeler HB (2001) Prevention of venous thromboembolism. Chest [Suppl] 119:132–175 Geerts WH, Heit JA, Clagett GP, Pineo GF, Colwell CW, Anderson FA, Wheeler HB (2001) Prevention of venous thromboembolism. Chest [Suppl] 119:132–175
41.
go back to reference Gillespie W, Murray D, Gregg PJ, Warwick D (2000) Prophylaxis against deep-vein thrombosis following total hip replacement: risks and benefits of prophylaxis against venous thromboembolism in orthopaedic surgery. J Bone Joint Surg Br 82:475–479CrossRefPubMed Gillespie W, Murray D, Gregg PJ, Warwick D (2000) Prophylaxis against deep-vein thrombosis following total hip replacement: risks and benefits of prophylaxis against venous thromboembolism in orthopaedic surgery. J Bone Joint Surg Br 82:475–479CrossRefPubMed
42.
go back to reference Gillies TE, Ruckley CV, Nixon SJ (1996) Still missing the boat with fatal pulmonary embolism. Br J Surg 83:1394–1395PubMed Gillies TE, Ruckley CV, Nixon SJ (1996) Still missing the boat with fatal pulmonary embolism. Br J Surg 83:1394–1395PubMed
43.
go back to reference Grady D, Wenger NK, Herrington D, Khan S, Furberg C, Hunninghake D, Vittinghoff E, Hulley S (2000) Heart and Estrogen/Progestin Replacement Study Research Group. Postmenopausal hormone therapy increased risk for venous thromboembolic disease. Ann Intern Med 132:689–696PubMed Grady D, Wenger NK, Herrington D, Khan S, Furberg C, Hunninghake D, Vittinghoff E, Hulley S (2000) Heart and Estrogen/Progestin Replacement Study Research Group. Postmenopausal hormone therapy increased risk for venous thromboembolic disease. Ann Intern Med 132:689–696PubMed
44.
go back to reference Haas S (2000) Deep vein thrombosis: beyond the operating table. Orthopedics 23 [Suppl 6]:629–632 Haas S (2000) Deep vein thrombosis: beyond the operating table. Orthopedics 23 [Suppl 6]:629–632
45.
go back to reference Hackenberg L, Liljenqvist U, Halm H, Winkelmann W (2001) Occlusion of the left common iliac artery and consecutive thromboembolism of the left popliteal artery following anterior lumbar interbody fusion. J Spinal Disord 14:365–368CrossRefPubMed Hackenberg L, Liljenqvist U, Halm H, Winkelmann W (2001) Occlusion of the left common iliac artery and consecutive thromboembolism of the left popliteal artery following anterior lumbar interbody fusion. J Spinal Disord 14:365–368CrossRefPubMed
46.
go back to reference Haentjens P (2000) Venous thromboembolism after total hip arthroplasty. A review of incidence and prevention during hospitalisation and after hospital discharge. Acta Orthop Belg 66:1–8 Haentjens P (2000) Venous thromboembolism after total hip arthroplasty. A review of incidence and prevention during hospitalisation and after hospital discharge. Acta Orthop Belg 66:1–8
47.
go back to reference Haentjens P, Lemaire R (2000) A pragmatic approach to prophylaxis of thromboembolic complications in orthopaedic surgery. Editions Scientifiques et Medicales Elsevier SAS (Paris), Surgical Techniques in Orthopaedics and Traumatology 55–010-D-30 Haentjens P, Lemaire R (2000) A pragmatic approach to prophylaxis of thromboembolic complications in orthopaedic surgery. Editions Scientifiques et Medicales Elsevier SAS (Paris), Surgical Techniques in Orthopaedics and Traumatology 55–010-D-30
48.
go back to reference Hamilton MG, Hull RD, Pineo GF (1994) Venous thromboembolism in neurosurgery and neurology patients: a review. Neurosurgery 34:280–296PubMed Hamilton MG, Hull RD, Pineo GF (1994) Venous thromboembolism in neurosurgery and neurology patients: a review. Neurosurgery 34:280–296PubMed
49.
go back to reference Heit JA (2001) Low-molecular-weight heparin: the optimal duration of prophylaxis against postoperative venous thromboembolism after total hip or knee replacement. Thromb Res 101:V163–V173CrossRefPubMed Heit JA (2001) Low-molecular-weight heparin: the optimal duration of prophylaxis against postoperative venous thromboembolism after total hip or knee replacement. Thromb Res 101:V163–V173CrossRefPubMed
50.
go back to reference Hull RD (2000) New insights into extended prophylaxis after orthopaedic surgery. The North American Fragmin Trial experience. Haemostasis 30 [Suppl 2]:95–100 Hull RD (2000) New insights into extended prophylaxis after orthopaedic surgery. The North American Fragmin Trial experience. Haemostasis 30 [Suppl 2]:95–100
51.
go back to reference Hull RD, Brant RF, Pineo GF (1999) Preoperative vs postoperative initiation of low molecular weight heparin prophylaxis against VTE in patients undergoing elective hip replacement. Arch Intern Med 159:137–141CrossRefPubMed Hull RD, Brant RF, Pineo GF (1999) Preoperative vs postoperative initiation of low molecular weight heparin prophylaxis against VTE in patients undergoing elective hip replacement. Arch Intern Med 159:137–141CrossRefPubMed
52.
go back to reference Hull RD, Pineo GF, MaC Isaac S (2001) Low-molecular-weight heparin prophylaxis. Preoperative versus postoperative initiation in patients undergoing elective hip surgery. Thromb Res 101:V155–V162CrossRefPubMed Hull RD, Pineo GF, MaC Isaac S (2001) Low-molecular-weight heparin prophylaxis. Preoperative versus postoperative initiation in patients undergoing elective hip surgery. Thromb Res 101:V155–V162CrossRefPubMed
53.
go back to reference Janku GV, Paiement GD, Green HD (1996) Prevention of venous thromboembolism in orthopaedics in the United States. Clin Orthop 325:313–321PubMed Janku GV, Paiement GD, Green HD (1996) Prevention of venous thromboembolism in orthopaedics in the United States. Clin Orthop 325:313–321PubMed
54.
go back to reference Kakkar AK, Williamson RCN (1999) Prevention of VTE in cancer patients. Semin Thromb Hemost 25:239–243PubMed Kakkar AK, Williamson RCN (1999) Prevention of VTE in cancer patients. Semin Thromb Hemost 25:239–243PubMed
55.
go back to reference Kearon C, Hirsch J (1995) Starting prophylaxis for VTE postoperatively. Arch Intern Med 155:366–372CrossRefPubMed Kearon C, Hirsch J (1995) Starting prophylaxis for VTE postoperatively. Arch Intern Med 155:366–372CrossRefPubMed
56.
go back to reference Khazim R, Boos N, Webb JK (1998) Progressive thrombotic occlusion of the left common iliac artery after anterior lumbar interbody fusion. Eur Spine J 7:239–241PubMed Khazim R, Boos N, Webb JK (1998) Progressive thrombotic occlusion of the left common iliac artery after anterior lumbar interbody fusion. Eur Spine J 7:239–241PubMed
57.
go back to reference Knop C, Bastian L, Lange U, Oeser M, Zdiiichavsky M, Blauth M (2002) Complications in surgical treatment of thoracolumbar injuries. Eur Spine J 11:214–226CrossRefPubMed Knop C, Bastian L, Lange U, Oeser M, Zdiiichavsky M, Blauth M (2002) Complications in surgical treatment of thoracolumbar injuries. Eur Spine J 11:214–226CrossRefPubMed
58.
go back to reference Kozak JA, O’Brien JP (1990) Simultaneous combined anterior and posterior fusion: an independent analysis of a treatment for disabled low-back pain patient. Spine 15:322–328PubMed Kozak JA, O’Brien JP (1990) Simultaneous combined anterior and posterior fusion: an independent analysis of a treatment for disabled low-back pain patient. Spine 15:322–328PubMed
59.
go back to reference Lee AYY, Levine MN (1999) The thrombophilic state induced by therapeutic agents in the cancer patient. Semin Thromb Hemost 25:137–145PubMed Lee AYY, Levine MN (1999) The thrombophilic state induced by therapeutic agents in the cancer patient. Semin Thromb Hemost 25:137–145PubMed
60.
go back to reference Lee HM, Suk KS, Moon SH, Kim DJ, Wang JM, Kim NH (2000) Deep vein thrombosis after major spinal surgery. Incidence in East Asian population. Spine 25:1827–1830CrossRefPubMed Lee HM, Suk KS, Moon SH, Kim DJ, Wang JM, Kim NH (2000) Deep vein thrombosis after major spinal surgery. Incidence in East Asian population. Spine 25:1827–1830CrossRefPubMed
61.
go back to reference Marsicano J, Mirovsky Y, Remer S, Bloom N, Neuwirth M (1994) Thrombotic occlusion of the left common iliac artery after an anterior retroperitoneal approach to the lumbar spine. Spine 19:357–359PubMed Marsicano J, Mirovsky Y, Remer S, Bloom N, Neuwirth M (1994) Thrombotic occlusion of the left common iliac artery after an anterior retroperitoneal approach to the lumbar spine. Spine 19:357–359PubMed
62.
go back to reference Matzsch T (2000) Thromboprophylaxis with low-molecular-weight heparin: economic considerations. Haemostasis 30 [Suppl 2]:141–145 Matzsch T (2000) Thromboprophylaxis with low-molecular-weight heparin: economic considerations. Haemostasis 30 [Suppl 2]:141–145
63.
go back to reference Mollan R (2000) Deep venous thrombosis: prophylaxis and treatment. Editions Scientifiques et Medicales Elsevier SAS (Paris), Surgical Techniques in Orthopaedics and Traumatology, 55–010-D-10 Mollan R (2000) Deep venous thrombosis: prophylaxis and treatment. Editions Scientifiques et Medicales Elsevier SAS (Paris), Surgical Techniques in Orthopaedics and Traumatology, 55–010-D-10
64.
go back to reference Muntz JE (2000) Deep vein thrombosis and pulmonary embolism in the perioperative patient. Am J Managed Care 6 [Suppl 20]:1045–1052 Muntz JE (2000) Deep vein thrombosis and pulmonary embolism in the perioperative patient. Am J Managed Care 6 [Suppl 20]:1045–1052
65.
go back to reference Murray DW, Britton AR, Bulstrode CJK (1996) Thromboprophylaxis and death after total hip replacement. J Bone Joint Surg Br 78:863–870CrossRefPubMed Murray DW, Britton AR, Bulstrode CJK (1996) Thromboprophylaxis and death after total hip replacement. J Bone Joint Surg Br 78:863–870CrossRefPubMed
66.
go back to reference National Institute of Health—Thrombosis and Embolism—Consensus Conference (1986) Prevention of venous thrombosis and pulmonary embolism. JAMA 256:744–749PubMed National Institute of Health—Thrombosis and Embolism—Consensus Conference (1986) Prevention of venous thrombosis and pulmonary embolism. JAMA 256:744–749PubMed
67.
go back to reference Nicolaides AN, et al (1997) Prevention of venous thromboembolism. Int Angiol 16:3–38PubMed Nicolaides AN, et al (1997) Prevention of venous thromboembolism. Int Angiol 16:3–38PubMed
68.
go back to reference Nurmohamed MT, Rosendaal FR, Buller HR, Dekker E, Hommes DW, Vandenbroucke JP, Briet E (1992) Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis. Lancet 340:152–156CrossRefPubMed Nurmohamed MT, Rosendaal FR, Buller HR, Dekker E, Hommes DW, Vandenbroucke JP, Briet E (1992) Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis. Lancet 340:152–156CrossRefPubMed
69.
go back to reference Nurmohamed MT, van Riel AM, Henkes CMA, Koopman MMW, Que GTH, d’Azemar P, Buller HR, ten Cate JW, Hoek JA, van der Meer J, van der Heul C, Turpie AGG, Haley S, Sicurella J, Gent M (1996) Low molecular weight heparin and compression stockings in the prevention of venous thromboembolism in neurosurgery. Thromb Haemost 75:233–238PubMed Nurmohamed MT, van Riel AM, Henkes CMA, Koopman MMW, Que GTH, d’Azemar P, Buller HR, ten Cate JW, Hoek JA, van der Meer J, van der Heul C, Turpie AGG, Haley S, Sicurella J, Gent M (1996) Low molecular weight heparin and compression stockings in the prevention of venous thromboembolism in neurosurgery. Thromb Haemost 75:233–238PubMed
70.
go back to reference Oda T, Fuji T, Fujita S, Kanemitsu N (2000) Deep venous thrombosis after posterior spinal surgery. Spine 25:2962–2967CrossRefPubMed Oda T, Fuji T, Fujita S, Kanemitsu N (2000) Deep venous thrombosis after posterior spinal surgery. Spine 25:2962–2967CrossRefPubMed
71.
go back to reference O’Shaughnessy DF (2000) Low-molecular-weight heparins in the prophylaxis and treatment of thrombo-embolic disease. Hematology 4:373–380PubMed O’Shaughnessy DF (2000) Low-molecular-weight heparins in the prophylaxis and treatment of thrombo-embolic disease. Hematology 4:373–380PubMed
72.
go back to reference Prestar FJ (1992) Prevention of thromboembolism complications with low molecular weight heparin in microneurosurgical lumbar intervertebral disk operations. Neurochirurgia 35:1–4PubMed Prestar FJ (1992) Prevention of thromboembolism complications with low molecular weight heparin in microneurosurgical lumbar intervertebral disk operations. Neurochirurgia 35:1–4PubMed
73.
go back to reference Pulmonary Embolism Prevention (PEP) Trial Collaborative Group (2000) Prevention of pulmonary embolism and deep vein thrombosis with low-dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet 355:1295–1302CrossRefPubMed Pulmonary Embolism Prevention (PEP) Trial Collaborative Group (2000) Prevention of pulmonary embolism and deep vein thrombosis with low-dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet 355:1295–1302CrossRefPubMed
74.
go back to reference Ramirez LF, Thisted R (1989) Complications and demographic characteristics of patients undergoing lumbar discectomy in community hospitals. Neurosurgery 25:226–231PubMed Ramirez LF, Thisted R (1989) Complications and demographic characteristics of patients undergoing lumbar discectomy in community hospitals. Neurosurgery 25:226–231PubMed
75.
go back to reference Raskas DS, Delamarter RB (1997) Occlusion of the left iliac artery after retroperitoneal exposure of the spine. Clin Orthop 338:86–89 Raskas DS, Delamarter RB (1997) Occlusion of the left iliac artery after retroperitoneal exposure of the spine. Clin Orthop 338:86–89
76.
go back to reference Rasmussen MS, Wille-Jorgensen P, Jorgensen LN (1995) Postoperative fatal pulmonary embolism in a general surgical department. Am J Surg 169:214–216CrossRefPubMed Rasmussen MS, Wille-Jorgensen P, Jorgensen LN (1995) Postoperative fatal pulmonary embolism in a general surgical department. Am J Surg 169:214–216CrossRefPubMed
77.
go back to reference Ravelli V, Marconi F, Lutzemberger L, Marini C, Di Ricco G, Genovesi M (1992) Il rischio di embolia polmonare in neurochirurgia. Minerva Anestesiol 58 [Suppl 1]:173–181 Ravelli V, Marconi F, Lutzemberger L, Marini C, Di Ricco G, Genovesi M (1992) Il rischio di embolia polmonare in neurochirurgia. Minerva Anestesiol 58 [Suppl 1]:173–181
78.
go back to reference Rokito SE, Schwartz MC, Neuwirth MG (1996) Deep vein thrombosis after major reconstructive spinal surgery. Spine 21:853–859CrossRefPubMed Rokito SE, Schwartz MC, Neuwirth MG (1996) Deep vein thrombosis after major reconstructive spinal surgery. Spine 21:853–859CrossRefPubMed
79.
go back to reference Rosendaal FR (1999) Risk factor for venous thrombotic disease. Thromb Haemost 82:610–619PubMed Rosendaal FR (1999) Risk factor for venous thrombotic disease. Thromb Haemost 82:610–619PubMed
80.
go back to reference Salvati EA, Pellegrini VD, Sharrock NE, Lotke PA, Murray DW, Potter H (2000) Recent advances in venous thromboembolic prophylaxis during and after total hip replacement. J Bone Joint Surg Am 82:252–270PubMed Salvati EA, Pellegrini VD, Sharrock NE, Lotke PA, Murray DW, Potter H (2000) Recent advances in venous thromboembolic prophylaxis during and after total hip replacement. J Bone Joint Surg Am 82:252–270PubMed
81.
go back to reference Scavarda D, Peruzzi P, Bazin A (1997) Hematomes extra-duraux rachidiens post-operatoires. Quatorze observations. Neurochirurgie 43:220–227PubMed Scavarda D, Peruzzi P, Bazin A (1997) Hematomes extra-duraux rachidiens post-operatoires. Quatorze observations. Neurochirurgie 43:220–227PubMed
82.
go back to reference Silverstein MD, Heit JA, Mohr DN (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 158:585–593PubMed Silverstein MD, Heit JA, Mohr DN (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 158:585–593PubMed
83.
go back to reference Smith MD, Bressler EL, Lonstein JE, Winter R, Pinto MR, Denis F (1994) Deep venous thrombosis and pulmonary embolism after major reconstructive operations on the spine. A prospective analysis of three hundred and seventeen patients. J Bone Joint Surg Am 76:980–985PubMed Smith MD, Bressler EL, Lonstein JE, Winter R, Pinto MR, Denis F (1994) Deep venous thrombosis and pulmonary embolism after major reconstructive operations on the spine. A prospective analysis of three hundred and seventeen patients. J Bone Joint Surg Am 76:980–985PubMed
84.
go back to reference Spain DA, Richardson JD, Polk HC, Bergamini TM, Wilson MA, Miller FB (1997) Venous thromboembolism in the high-risk trauma patient: do risks justify aggressive screening and prophylaxis? J Trauma 42:463–469PubMed Spain DA, Richardson JD, Polk HC, Bergamini TM, Wilson MA, Miller FB (1997) Venous thromboembolism in the high-risk trauma patient: do risks justify aggressive screening and prophylaxis? J Trauma 42:463–469PubMed
85.
go back to reference Spanier DE, Stambough JL (2000) Delayed postoperative epidural hematoma formation after heparinization in lumbar spinal surgery. J Spinal Disord 13:46–49CrossRefPubMed Spanier DE, Stambough JL (2000) Delayed postoperative epidural hematoma formation after heparinization in lumbar spinal surgery. J Spinal Disord 13:46–49CrossRefPubMed
86.
go back to reference Stolke D, Sollmann WP, Seifert V (1989) Intra- and postoperative complications in lumbar disc surgery. Spine 14:56–59PubMed Stolke D, Sollmann WP, Seifert V (1989) Intra- and postoperative complications in lumbar disc surgery. Spine 14:56–59PubMed
87.
go back to reference Thromboembolic Risk Factors (THRIFT) Consensus Group (1992) Risk of and prophylaxis for VTE in hospital patients. BMJ 305:567–574PubMed Thromboembolic Risk Factors (THRIFT) Consensus Group (1992) Risk of and prophylaxis for VTE in hospital patients. BMJ 305:567–574PubMed
88.
go back to reference Uden A (1979) Thromboembolic complications following scoliosis surgery in Scandinavia. Acta Orthop Scand 50:175–178PubMed Uden A (1979) Thromboembolic complications following scoliosis surgery in Scandinavia. Acta Orthop Scand 50:175–178PubMed
89.
go back to reference Warwick D, Bannister GC, Glew D, Mitchelmore A, Thornton M, Peters TJ, Brookes S (1995) Perioperative low-molecular-weight heparin. Is it effective and safe? J Bone Joint Surg Br 77:715–719PubMed Warwick D, Bannister GC, Glew D, Mitchelmore A, Thornton M, Peters TJ, Brookes S (1995) Perioperative low-molecular-weight heparin. Is it effective and safe? J Bone Joint Surg Br 77:715–719PubMed
90.
go back to reference Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L, Clement C, Robinson KS, Lewandowski B (1997) Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet 350:1795–1798CrossRefPubMed Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L, Clement C, Robinson KS, Lewandowski B (1997) Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet 350:1795–1798CrossRefPubMed
91.
go back to reference Wen DY, Hall WA (1998) Complications of subcutaneous low-dose heparin therapy in neurosurgical patients. Surg Neurol 50:521–525CrossRefPubMed Wen DY, Hall WA (1998) Complications of subcutaneous low-dose heparin therapy in neurosurgical patients. Surg Neurol 50:521–525CrossRefPubMed
92.
go back to reference West JL (1998) Deep vein thrombosis in spinal surgery. Curr Opin Orthop 9:43–47 West JL (1998) Deep vein thrombosis in spinal surgery. Curr Opin Orthop 9:43–47
93.
go back to reference West JL, Anderson LD (1992) Incidence of deep vein thrombosis in major adult spinal surgery. Spine [Suppl] 17:254–257 West JL, Anderson LD (1992) Incidence of deep vein thrombosis in major adult spinal surgery. Spine [Suppl] 17:254–257
94.
go back to reference Wisowski DK, Talarico R, Bacsanyii J, Botstein P (1998) Spinal and epidural hematoma and low-molecular-weight heparin. Letter to the editor. N Engl J Med 338:1774 Wisowski DK, Talarico R, Bacsanyii J, Botstein P (1998) Spinal and epidural hematoma and low-molecular-weight heparin. Letter to the editor. N Engl J Med 338:1774
95.
go back to reference Wood KB, Kos PB, Abnet JK, Ista C (1997) Prevention of deep-vein thrombosis after major spinal surgery: a comparison study of external devices. J Spinal Disord 10:209–214PubMed Wood KB, Kos PB, Abnet JK, Ista C (1997) Prevention of deep-vein thrombosis after major spinal surgery: a comparison study of external devices. J Spinal Disord 10:209–214PubMed
Metadata
Title
Prevention of venous thromboembolism in spinal surgery
Authors
S. Brambilla
C. Ruosi
G. A. La Maida
S. Caserta
Publication date
01-02-2004
Publisher
Springer-Verlag
Published in
European Spine Journal / Issue 1/2004
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-003-0538-7

Other articles of this Issue 1/2004

European Spine Journal 1/2004 Go to the issue