Top

Journal of Hepato-Biliary-Pancreatic Sciences

Published in:

01-05-2011 | Topics

The current potential of high-intensity focused ultrasound for pancreatic carcinoma

Authors: Atsushi Sofuni, Fuminori Moriyasu, Takatomo Sano, Kota Yamada, Fumihide Itokawa, Takayoshi Tsuchiya, Shujiro Tsuji, Toshio Kurihara, Kentaro Ishii, Takao Itoi

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 3/2011

Abstract

Introduction

Pancreatic carcinoma has one of the poorest prognoses among malignant tumors. Many pancreatic carcinoma patients who undergo common treatments, such as surgery, radio-chemotherapy and chemotherapy, gained little benefit because of the histological characteristics.

Materials and methods

HIFU is a new technique of noninvasive treatment for unresectable pancreatic carcinoma. HIFU has the ability to ablate the deep tissues inside body from an external source using high-intensity focused ultrasound. The effects of HIFU can result in cell destruction and tissue necrosis.

Results

Results from study in China in 251 patients with advanced pancreatic carcinoma suggested that HIFU treatment could reduce the size of tumors without causing complications and prolong survival. Moreover, according to some reports from China, HIFU treatment is suggested to be useful as the one of palliative treatments for unresectable pancreatic carcinoma. Our case of HIFU therapy for pancreatic carcinoma is presented including pathological findings in this paper. The results suggested that HIFU treatment might be effective in controlling local tumor.

Conclusion

HIFU therapy may have the possibility of becoming one of the combination therapies for treating pancreatic carcinoma in the future.

World Health Organization. The world health report. Geneva: WHO; 2000.

Rothman H, Cantrell JE, Lokich J, et al. Continuous infusion of 5-fluorouracil plus weekly cisplatin for pancreatic carcinoma. Cancer. 1991;68:264–8.PubMedCrossRef

The Gastrointestinal Tumor Study Group. Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst. 1988;80:751–5.CrossRef

Burris HA, Moore Mj, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403–13.PubMed

Dubinsky TJ, Cuevas C, Dighe MK, et al. High-intensity focused ultrasound: current potential and oncologic applications. AJR. 2008;190:191–9.PubMedCrossRef

He S-X, Xiong L-L, Yao S-S, et al. The preclinical research of high intensity focused ultrasound. J Beijing Med Univ. 1999; 31:573–76.

Lindstrom PA. Prefrontal ultrasonic irradiation: a substitute for lobotomy. Arch Neurol Psych. 1954;72:399–425.

Fry W, Barnard J, Fry F, Krumins R, Brennan J. Ultrasonic lesions in the mammalian central nervous system with ultrasound. Science. 1955;122:517–8.PubMedCrossRef

Hynynen K, Lulu BA. Hyperthermia in cancer treatment. Invest Radiol. 1990;25:824–34.PubMedCrossRef

10.

Sanghvi NT, Foster RS, Bihrle R, et al. Noninvasive surgery of prostate tissue by high intensity focused ultrasound: an updated report. Eur J Ultrasound. 1999;9:19–29.PubMedCrossRef

11.

Gelet A, Chapelon JY, Bouvier R, et al. Transrectal high-intensity focused ultrasound: minimally invasive therapy of localized prostate cancer. J Endourol. 2000;14:519–28.PubMedCrossRef

12.

Visioli AG, Rivens IH, ter Haar GR, et al. Preliminary results of a phase I dose escalation clinical trial using focused ultrasound in the treatment of localised tumours. Eur J Ultrasound. 1999;9:11–8.PubMedCrossRef

13.

ter Haar G. Biological effects of ultrasound in clinical applications. In: Suslick K, editor. Ultrasound: its chemical, physical, and biological effects. New York: VCH; 1988. p. 305–20.

14.

Yuan C, Yang L, Yao C. Observation of high intensity focused ultrasound treating 40 cases of pancreatic cancer [in Chinese]. Chin J Clin Hepatol. 2003;19:145–6.

15.

Sofuni A, Itoi T, Itokawa F, et al. Usefulness of contrast-enhanced ultrasonography in determining treatment efficacy and outcome after pancreatic cancer chemotherapy. World J Gastroenterol. 2008;14:7183–91.PubMedCrossRef

16.

He SX, Wang GM. The noninvasive treatment of 251 cases of advanced pancreatic cancer with focused ultrasound surgery. In: Andrew MA, Crum LA, Vaezy S, editors. Proceedings from the 2nd International Symposium on Therapeutic Ultrasound. Seattle: University of Washington; 2002. p. 51–6.

17.

Gu Y, Wang G, Xia H, et al. Application of high intensity focused ultrasound in treating 45 cases of carcinoma of the pancreas [in Chinese]. Fudan Univ J Med Sci. 2005;31:135–41.

18.

Wang RS, Mu QX, Liu LX, Shu YQ. A clinical study of thermotherapy of HIFU in combination with chemotherapy on treating advanced pancreatic cancer [in Chinese]. Acta Nanjing Med Univ. 2003;23:460–3.

19.

Wang X, Sun JZ. Preliminary study of high intensity focused ultrasound in treating patients with advanced pancreatic carcinoma [in Chinese]. Chin J Gen Surg. 2002;17:654–5.

20.

Wu F, Wang ZB, Zhu H, et al. Feasibility of US guided high-intensity focused ultrasound treatment in patients with advanced pancreatic cancer: initial experience. Radiology. 2005;236:1034–40.PubMedCrossRef

21.

Xie DR, Chen D, Teng H. A multicenter nonrandomized clinical study of high intensity focused ultrasound in treating patients with local advanced pancreatic carcinoma [in Chinese]. Chin J Clin Oncol. 2003;30:630–4.

22.

Xiong LL, He CJ, Yao SS, et al. The preliminary clinical results of the treatment for advanced pancreatic carcinoma by high intensity focused ultrasound [in Chinese]. Chin J Gen Surg. 2005;16:345–7.

23.

Xu YQ, Wang GM, Gu YZ, Zhang HF. The acesodyne effect of high intensity focused ultrasound on the treatment of advanced pancreatic carcinoma [in Chinese]. Clin Med J China. 2003;10:322–3.

Title: The current potential of high-intensity focused ultrasound for pancreatic carcinoma
Authors: Atsushi Sofuni
Fuminori Moriyasu
Takatomo Sano
Kota Yamada
Fumihide Itokawa
Takayoshi Tsuchiya
Shujiro Tsuji
Toshio Kurihara
Kentaro Ishii
Takao Itoi
Publication date: 01-05-2011
Publisher: Springer Japan
Published in: Journal of Hepato-Biliary-Pancreatic Sciences / Issue 3/2011
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI: https://doi.org/10.1007/s00534-010-0355-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The current potential of high-intensity focused ultrasound for pancreatic carcinoma

Abstract

Introduction

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 3/2011

Endoscopic ultrasound-guided injection therapy for hepatobiliary disease

Hepatocyte growth factor promotes liver regeneration induced by transfusion of bone marrow mononuclear cells in a murine acute liver failure model

Endoscopic ultrasonography-guided ablation therapy

Hepatocellular carcinoma during pregnancy: is hepatocellular carcinoma more aggressive in pregnant patients?

A pictorial review of benign hepatocellular nodular lesions: comprehensive radiological assessment incorporating the concept of anomalous portal tract syndrome

The effect of methylene blue during orthotopic liver transplantation on post reperfusion syndrome and postoperative graft function