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Supportive Care in Cancer
Published in: Supportive Care in Cancer 11/2023

01-11-2023 | Research

Psychological distress as a risk factor for the efficacy of chemotherapy in advanced gastric cancer patients

Authors: Yongkang Zhang, Chen Gan, Jian Xu, Lulian Pang, Wen Li, Huaidong Cheng

Published in: Supportive Care in Cancer | Issue 11/2023

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Abstract

Aim

To assess the relationship between psychological distress and quality of life (QoL), cancer-related fatigue (CRF), and chemotherapy efficacy in advanced gastric cancer patients.

Methods

Advanced gastric cancer patients (39 with psychological distress and 35 without psychological distress) completed the Distress Thermometer (DT), QoL, and CRF test before receiving chemotherapy and assessed the efficacy after completing 2 courses of chemotherapy.

Results

Psychological distress was a significant factor in the efficacy of chemotherapy in advanced gastric cancer patients (χ2 = 6.324; p = 0.042). Compared to advanced gastric cancer patients with no psychological distress, advanced gastric cancer patients with psychological distress had a poorer QoL (50.41 ± 6.17 vs. 60.01 ± 7.94, t =  − 5.882, p < 0.01) and more pronounced CRF (5.75 ± 1.16 vs. 3.22 ± 0.75, t = 11.231, p < 0.01) while receiving chemotherapy. FACT-G (p = 0.0035, r =  − 0.4568), as well as PFS (p < 0.0001, r = 0.6599), correlated significantly with efficacy for patients in the psychological distress group. The FACT-G (p = 0.0134, r =  − 0.4139) of patients in the no psychological distress group correlated significantly with efficacy.

Conclusion

Psychological distress has a negative impact on QoL, CRF, and efficacy and may be a potential risk for the efficacy of palliative chemotherapy in advanced gastric cancer patients.
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Metadata
Title
Psychological distress as a risk factor for the efficacy of chemotherapy in advanced gastric cancer patients
Authors
Yongkang Zhang
Chen Gan
Jian Xu
Lulian Pang
Wen Li
Huaidong Cheng
Publication date
01-11-2023
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 11/2023
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-023-08143-1

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