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01-12-2023 | Laser | Research

Efficacy of photobiomodulation in the treatment of oral mucositis in patients undergoing antineoplastic therapy: systematic review and meta-analysis

Authors: Adriana Regina Cruz, Eliana Maria Minicucci, Marluci Betini, Luciana Almeida-Lopes, Victor Tieghi Neto, Antonio José Maria Cataneo

Published in: Supportive Care in Cancer | Issue 12/2023

Abstract

Purpose

To evaluate the effectiveness of photobiomodulation in the treatment of oral mucositis.

Methods

Systematic review and meta-analysis encompassing in the electronic databases: LILACS, MEDLINE, EMBASE, COCHRANE, SCOPUS, WEB OF SCIENCE, and CINAHL and in http://clinicaltrials.gov. Eligibility criteria were randomized, non-randomized, and observational studies that used photobiomodulation for the treatment of oral mucositis. The endpoints were reduction in the severity of oral mucositis, duration of lesions, and pain reduction. For data analysis, the Review Manager 5.4 program was used.

Results

A total of 316 studies were identified, 297 in the electronic databases and 19 in http://clinicaltrials.gov. After removing duplicates, 260 studies were selected for title and abstract reading, of which 223 were excluded. A total of 37 studies were chosen for full reading, of which 6 were included in the review, totaling 299 patients. The treatment used was photobiomodulation. The patients were divided into two groups: the laser group used only photobiomodulation or associated with other therapies, and the control group did not use photobiomodulation. For the endpoint reduction in the severity of oral mucositis (OM), the chance of reduction of the OM was greater in the laser group as compared to the control group. For the endpoints duration of OM lesions and pain reduction, it was not possible to carry out a meta-analysis due to the high heterogeneity between studies. In the interpretation of the meta-analysis, the reduction in the severity of oral mucositis was greater in the group that received photobiomodulation.

Conclusion

Photobiomodulation was effective in the treatment of oral mucositis.

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Title: Efficacy of photobiomodulation in the treatment of oral mucositis in patients undergoing antineoplastic therapy: systematic review and meta-analysis
Authors: Adriana Regina Cruz
Eliana Maria Minicucci
Marluci Betini
Luciana Almeida-Lopes
Victor Tieghi Neto
Antonio José Maria Cataneo
Publication date: 01-12-2023
Publisher: Springer Berlin Heidelberg
Keyword: Laser
Published in: Supportive Care in Cancer / Issue 12/2023
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-023-08105-7

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