Top

Supportive Care in Cancer

Published in:

01-08-2019 | Care | Review Article

Opening up disruptive ways of management in cancer pain: the concept of multimorphic pain

Authors: Antoine Lemaire, Brigitte George, Caroline Maindet, Alexis Burnod, Gilles Allano, Christian Minello

Published in: Supportive Care in Cancer | Issue 8/2019

Abstract

Purpose

Following a series of articles reviewing the basics of cancer pain management, in this article, we develop the guiding principle of our philosophy: the concept of multimorphic pain and how to integrate it as the innovative cornerstone of supportive care in cancer.

Method

Critical reflection based on literature analysis and clinical practice.

Results

This model aims to break with standard approaches, offering a more dynamic and exhaustive vision of cancer pain as a singular clinical entity, taking into account its multimorphic characteristics (cancer pain experience can and will change during cancer: aetiology, physiopathology, clinical presentation and consequences of pain) and the disruptive elements that can occur to influence its evolution (cancer evolution, concomitant treatments, pain from associated diseases, comorbidities and complications, or modifications in the environment). Our model establishes the main key stages for interdisciplinary management of cancer pain:

Early, personalised management that is targeted and multimodal;
Identification, including in advance, of potential disruptive elements throughout the care pathway, using an exhaustive approach to all the factors influencing pain, leading to patient and caregiver education;
Optimal analgesic balance throughout the care pathway;
Integration of this concept into a systemic early supportive care model from the cancer diagnosis.

Conclusions

Given the difficulties still present in the management of pain in cancer, and whilst cancer is often considered as a chronic condition, the concept of multimorphic pain proposes a practical, optimised and innovative approach for clinicians and, ultimately, for patients experiencing pain.

Breivik H, Cherny N, Collett B, de Conno F, Filbet M, Foubert AJ, Cohen R, Dow L (2009) Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes. Ann Oncol 20:1420–1433. https://doi.org/10.1093/annonc/mdp001 CrossRefPubMed

Valeberg BT, Rustøen T, Bjordal K, Hanestad BR, Paul S, Miaskowski C (2008) Self-reported prevalence, etiology, and characteristics of pain in oncology outpatients. Eur J Pain 12:582–590. https://doi.org/10.1016/j.ejpain.2007.09.004 CrossRefPubMed

Institut national du Cancer (INCA) (2012) Synthèse de l’enquête nationale 2010 sur la prise en charge de la douleur chez des patients adultes atteints de cancer. www.e-cancer.fr/content/download/63502/571325/file/ENQDOUL12.pdf. Accessed 17 July 2018

Greco MT, Roberto A, Corli O, Deandrea S, Bandieri E, Cavuto S, Apolone G (2014) Quality of cancer pain management: an update of a systematic review of undertreatment of patients with cancer. J Clin Oncol 32:4149–4154. https://doi.org/10.1200/JCO.2014.56.0383 CrossRefPubMed

Breuer B, Chang VT, Von Roenn JH et al (2015) How well do medical oncologists manage chronic cancer pain? A national survey. Oncologist 20:202–209. https://doi.org/10.1634/theoncologist.2014-0276 CrossRefPubMedPubMedCentral

Mayor S (2000) Survey of patients shows that cancer pain still undertreated. BMJ 321:1309–1309. https://doi.org/10.1136/bmj.321.7272.1309/b CrossRefPubMedCentral

MacDonald N, Ayoub J, Farley J, Foucault C, Lesage P, Mayo N (2002) A Quebec survey of issues in cancer pain management. J Pain Symptom Manag 23:39–47. https://doi.org/10.1016/S0885-3924(01)00374-8 CrossRef

Hsieh RK (2005) Pain control in Taiwanese patients with cancer: a multicenter, patient-oriented survey. J Formos Med Assoc 104:913–919PubMed

Deandrea S, Montanari M, Moja L, Apolone G (2008) Prevalence of undertreatment in cancer pain. A review of published literature. Ann Oncol Off J Eur Soc Med Oncol 19:1985–1991. https://doi.org/10.1093/annonc/mdn419 CrossRef

10.

Portenoy R, Koh M (2010) Cancer pain syndromes. In: Press CCU, Bruera E, Portenoy RK (eds) Cancer pain. Assessment and management, vol 4. Cambridge University Press, Cambridge, pp 53–88

11.

Higginson IJ, Murtagh FEM (2010) Cancer pain epidemiology. In: Bruera E, Portenoy RK (eds) Cancer pain. assessment and management, vol 3. Cambridge University Press, Cambridge, pp 37–52

12.

National Cancer Institute Surveillance, epidemilogy, and end results program (2017) Annual Report to the Nation 2017: Special Section: Survival. https://seer.cancer.gov/report_to_nation/survival.html. Accessed 17 July 2018

13.

Institut National du Cancer (2010) Survie attendue des patients atteints de cancers en France : état des lieux. www.e-cancer.fr/content/download/96009/1022035/file/RAPSURVIE10. Accessed 17 July 2018

14.

Institut de veille sanitaire (2016) Survie des personnes atteintes de cancer en France métropolitaine, diagnostiquées entre 1989 et 2010, suivies jusqu’en 2013. http://invs.santepubliquefrance.fr/Dossiers-thematiques/Maladies-chroniques-et-traumatismes/Cancers/Surveillance-epidemiologique-d

15.

Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, Ripamonti CI, ESMO Guidelines Committee (2018) Management of cancer pain in adult patients: ESMO clinical practice guidelines†. Ann Oncol 29:166–191. https://doi.org/10.1093/annonc/mdy152 CrossRef

16.

Bennett MI, Eisenberg E, Ahmedzai SH, Bhaskar A, O’Brien T, Mercadante S, Krčevski Škvarč N, Vissers K, Wirz S, Wells C, Morlion B (2018) Standards for the management of cancer-related pain across Europe. A position paper from the EFIC Task Force on Cancer Pain. Eur J Pain 23:660–668. https://doi.org/10.1002/ejp.1346 CrossRef

17.

Delorme T, Wood C, Bartaillard A, et al. (2004) [2003 clinical practice guideline: standards, options and recommendations for pain assessment in adult and children with cancer]. http://www.sfetd-douleur.org/sites/default/files/u3/docs/sorevaluation.pdf. Accessed 17 July 2018

18.

Raffa RB, Pergolizzi JV (2014) A modern analgesics pain “pyramid”. J Clin Pharm Ther 39:4–6. https://doi.org/10.1111/jcpt.12110 CrossRefPubMed

19.

Wilson J, Stack C, Hester J (2014) Recent advances in cancer pain management. F1000Prime Rep 6:10. https://doi.org/10.12703/P6-10 CrossRefPubMedPubMedCentral

20.

Hochberg U, Elgueta MF, Perez J (2017) Interventional analgesic management of lung cancer pain. Front Oncol 7:17. https://doi.org/10.3389/fonc.2017.00017 CrossRefPubMedPubMedCentral

21.

Chwistek M (2017) Recent advances in understanding and managing cancer pain. F1000Research 6:945. https://doi.org/10.12688/f1000research.10817.1 CrossRefPubMedPubMedCentral

22.

Candido KD, Kusper TM, Knezevic NN (2017) New cancer pain treatment options. Curr Pain Headache Rep 21:12. https://doi.org/10.1007/s11916-017-0613-0 CrossRefPubMed

23.

Carvajal G, Dupoiron D, Seegers V, Lebrec N, Boré F, Dubois PY, Leblanc D, Delorme T, Jubier-Hamon S (2018) Intrathecal drug delivery systems for refractory pancreatic cancer pain. Anesth Analg 126:2038–2046. https://doi.org/10.1213/ANE.0000000000002903 CrossRefPubMed

24.

Bernstein JH (2015) Transdisciplinarity: a review of its origins, development, and current issues. Journal of Research Practice,11, Article R1. http://jrp.icaap.org/index.php/jrp/article/view/510/412 Accessed 17 July 2018

25.

Choi BCK, Pak AWP (2007) Multidisciplinarity, interdisciplinarity, and transdisciplinarity in health research, services, education and policy: 2. Promotors, barriers, and strategies of enhancement. Clin Invest Med 30:224–232CrossRef

26.

Choi BCK, Pak AWP (2006) Multidisciplinarity, interdisciplinarity and transdisciplinarity in health research, services, education and policy: 1. Definitions, objectives, and evidence of effectiveness. Clin Invest Med 29:351–364PubMed

27.

Hui D, Bruera E (2015) Models of integration of oncology and palliative care. Ann Palliat Med 4:89–98. https://doi.org/10.3978/j.issn.2224-5820.2015.04.01 CrossRefPubMed

28.

Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ (2010) Early palliative care for patients with metastatic non–small-cell lung cancer. N Engl J Med 363:733–742. https://doi.org/10.1056/NEJMoa1000678 CrossRefPubMed

29.

Temel JS, Greer JA, El-Jawahri A et al (2017) Effects of early integrated palliative care in patients with lung and GI cancer: a randomized clinical trial. J Clin Oncol 35:834–841. https://doi.org/10.1200/JCO.2016.70.5046 CrossRefPubMed

30.

Zhi WI, Smith TJ (2015) Early integration of palliative care into oncology: evidence, challenges and barriers. Ann Palliat Med 4:122–131. https://doi.org/10.3978/j.issn.2224-5820.2015.07.03 CrossRefPubMed

31.

Bakitas MA, Tosteson TD, Li Z, Lyons KD, Hull JG, Li Z, Dionne-Odom JN, Frost J, Dragnev KH, Hegel MT, Azuero A, Ahles TA (2015) Early versus delayed initiation of concurrent palliative oncology care: patient outcomes in the ENABLE III randomized controlled trial. J Clin Oncol 33:1438–1445. https://doi.org/10.1200/JCO.2014.58.6362 CrossRefPubMedPubMedCentral

32.

Temel JS, Greer JA, Admane S, Gallagher ER, Jackson VA, Lynch TJ, Lennes IT, Dahlin CM, Pirl WF (2011) Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non–small-cell lung cancer: results of a randomized study of early palliative care. J Clin Oncol 29:2319–2326. https://doi.org/10.1200/JCO.2010.32.4459 CrossRefPubMed

33.

National Center for Complementary and Integrative Health (NCCIH) (2016) Complementary, alternative, or integrative health: what’s in a name? https://nccih.nih.gov/health/integrative-health#integrative. Accessed 17 July 2018

34.

Strada E, Portenoy R (2017) Psychological, rehabilitative, and integrative therapies for cancer pain. Uptodate. https://www.uptodate.com/contents/psychological-rehabilitative-and-integrative-therapies-for-cancer-pain#H44713544. Accessed 17 July 2018

35.

Greenlee H, DuPont-Reyes MJ, Balneaves LG et al (2017) Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin 67:194–232. https://doi.org/10.3322/caac.21397 CrossRefPubMedPubMedCentral

36.

Raphael J, Hester J, Ahmedzai S, Barrie J, Farqhuar-Smith P, Williams J, Urch C, Bennett MI, Robb K, Simpson B, Pittler M, Wider B, Ewer-Smith C, DeCourcy J, Young A, Liossi C, McCullough R, Rajapakse D, Johnson M, Duarte R, Sparkes E (2010) Cancer pain: part 2: physical, interventional and complimentary therapies; management in the community; acute, treatment-related and complex cancer pain: a perspective from the British Pain Society Endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners: Table 1. Pain Med 11:872–896. https://doi.org/10.1111/j.1526-4637.2010.00841.x CrossRefPubMed

37.

Ernst E, Pittler MH, Wider B, Boddy K (2007) Complementary therapies for pain management: an evidence-based approach. Complement Ther pain Manag an evidence-based approach

38.

Bruera E, Hui D (2010) Integrating supportive and palliative care in the trajectory of cancer: establishing goals and models of care. J Clin Oncol 28:4013–4017. https://doi.org/10.1200/JCO.2010.29.5618 CrossRefPubMed

39.

Epstein RM, Duberstein PR, Fenton JJ, Fiscella K, Hoerger M, Tancredi DJ, Xing G, Gramling R, Mohile S, Franks P, Kaesberg P, Plumb S, Cipri CS, Street RL Jr, Shields CG, Back AL, Butow P, Walczak A, Tattersall M, Venuti A, Sullivan P, Robinson M, Hoh B, Lewis L, Kravitz RL (2016) Effect of a patient-centered communication intervention on oncologist-patient communication, quality of life, and health care utilization in advanced cancer. JAMA Oncol 3:92–100. https://doi.org/10.1001/jamaoncol.2016.4373 CrossRef

40.

Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M (2010) It’s not over when it’s over: long-term symptoms in cancer survivors—a systematic review. Int J Psychiatry Med 40:163–181. https://doi.org/10.2190/PM.40.2.c CrossRefPubMed

41.

Lemaire A, Plançon M, Bubrovszky M (2014) Kétamine et dépression: vers de nouvelles perspectives thérapeutiques en soins de support ? Psycho-Oncologie 8:59–67. https://doi.org/10.1007/s11839-014-0453-7 CrossRef

42.

Jordan K, Aapro M, Kaasa S, Ripamonti CI, Scotté F, Strasser F, Young A, Bruera E, Herrstedt J, Keefe D, Laird B, Walsh D, Douillard JY, Cervantes A (2018) European Society for Medical Oncology (ESMO) position paper on supportive and palliative care. Ann Oncol 29:36–43. https://doi.org/10.1093/annonc/mdx757 CrossRefPubMed

43.

Bruera E, Hui D (2016) Palliative care and supportive care. In: Bruera E, Higginson I, von Gunten CF, Morita T (eds) Textbook of Palliative Medicine and Supportive Care, Secong edn. CRC Press, Taylor & Francis Group, Boca Raton, pp 97–102

44.

Hui D (2014) Definition of supportive care. Curr Opin Oncol 26:372–379. https://doi.org/10.1097/CCO.0000000000000086 CrossRefPubMed

45.

Hui D, De La Cruz M, Mori M et al (2013) Concepts and definitions for “supportive care,” “best supportive care,” “palliative care,” and “hospice care” in the published literature, dictionaries, and textbooks. Support Care Cancer 21:659–685. https://doi.org/10.1007/s00520-012-1564-y CrossRefPubMed

46.

Consensus on the Core Ideology of MASCC (2003). Definition of Supportive Care. http://www.mascc.org/index.php?option=com_content&view¼article&id=493:mascc-strategic-plan&catid=30:navigation. Accessed 17 July 2010

47.

Frampton S, Guastello S, Brady C, et al. (2008) Patient Centered Care Improvement Guide. Planetree, Inc. and Picker Institute. http://www.ihi.org/resources/Pages/Tools/PatientCenteredCareImprovementGuide.aspx. Accessed 17 July 2018

48.

World Health Organization (2016) Framework on integrated people-centred health services. Sixty-ninth World Health Assembly. http://apps.who.int/gb/ebwha/pdf_files/WHA69/A69_39-en.pdf?ua=1&ua=1. Accessed 17 July 2018

49.

Dy SM, Isenberg SR, Al Hamayel NA (2017) Palliative care for cancer survivors. Med Clin North Am 101:1181–1196. https://doi.org/10.1016/J.MCNA.2017.06.009 CrossRefPubMed

50.

van Hecke O, Torrance N, Smith BH (2013) Chronic pain epidemiology - where do lifestyle factors fit in? Br J Pain 7:209–217. https://doi.org/10.1177/2049463713493264 CrossRefPubMedPubMedCentral

51.

World Health Organization (2018) Palliative care. http://www.who.int/en/news-room/fact-sheets/detail/palliative-care. Accessed 17 July 2018

52.

Dalal S, Palla S, Hui D, Nguyen L, Chacko R, Li Z, Fadul N, Scott C, Thornton V, Coldman B, Amin Y, Bruera E (2011) Association between a name change from palliative to supportive care and the timing of patient referrals at a comprehensive cancer center. Oncologist 16:105–111. https://doi.org/10.1634/theoncologist.2010-0161 CrossRefPubMedPubMedCentral

53.

Cherny NI, Catane R, Kosmidis P (2003) ESMO takes a stand on supportive and palliative care. Ann Oncol 14:1335–1337. https://doi.org/10.1093/annonc/mdg379 CrossRefPubMed

54.

Fadul N, Elsayem A, Palmer JL, del Fabbro E, Swint K, Li Z, Poulter V, Bruera E (2009) Supportive versus palliative care: what’s in a name? Cancer 115:2013–2021. https://doi.org/10.1002/cncr.24206 CrossRefPubMed

55.

Zimmermann C, Swami N, Krzyzanowska M, Leighl N, Rydall A, Rodin G, Tannock I, Hannon B (2016) Perceptions of palliative care among patients with advanced cancer and their caregivers. CMAJ 188:217–227. https://doi.org/10.1503/cmaj.151171 CrossRef

56.

Institut national du cancer (2016) Rapport d’expertise de l’INCa : “Axes opportuns d’évolution du panier de soins oncologiques de support”, octobre 2016. http://www.e-cancer.fr/Expertises-et-publications/Catalogue-des-publications/Axes-opportuns-d-evolution-du-panier-des-soins-oncologiques-de-support-Reponse-saisine. Accessed 17 July 2018

57.

van den Beuken-van Everdingen MHJ, Hochstenbach LMJ, Joosten EAJ et al (2016) Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manag 51:1070–1090.e9. https://doi.org/10.1016/j.jpainsymman.2015.12.340 CrossRef

58.

MHJ VDB-VE, De Rijke JM, Kessels AG et al (2007) Prevalence of pain in patients with cancer: a systematic review of the past 40 years. Ann Oncol 18:1437–1449. https://doi.org/10.1093/annonc/mdm056 CrossRef

59.

Ferrell B, Sun V, Hurria A, Cristea M, Raz DJ, Kim JY, Reckamp K, Williams AC, Borneman T, Uman G, Koczywas M (2015) Interdisciplinary palliative care for patients with lung cancer. J Pain Symptom Manag 50:758–767. https://doi.org/10.1016/j.jpainsymman.2015.07.005 CrossRef

60.

Higginson IJ, Booth S (2011) The randomized fast-track trial in palliative care: role, utility and ethics in the evaluation of interventions in palliative care? Palliat Med 25:741–747. https://doi.org/10.1177/0269216311421835 CrossRefPubMed

61.

Tuggey EM, Lewin WH (2014) A multidisciplinary approach in providing transitional care for patients with advanced cancer. Ann Palliat Med 3:139–143. https://doi.org/10.3978/j.issn.2224-5820.2014.07.02 CrossRefPubMed

62.

Weissman DE, Meier DE (2011) Identifying patients in need of a palliative care assessment in the hospital setting: a consensus report from the center to advance palliative care. J Palliat Med 14:17–23. https://doi.org/10.1089/jpm.2010.0347 CrossRefPubMed

63.

Gade G, Venohr I, Conner D, McGrady K, Beane J, Richardson RH, Williams MP, Liberson M, Blum M, Penna RD (2008) Impact of an inpatient palliative care team: a randomized controlled trial. J Palliat Med 11:180–190. https://doi.org/10.1089/jpm.2007.0055 CrossRefPubMed

64.

Brumley R, Enguidanos S, Jamison P, Seitz R, Morgenstern N, Saito S, McIlwane J, Hillary K, Gonzalez J (2007) Increased satisfaction with care and lower costs: results of a randomized trial of in-home palliative care. J Am Geriatr Soc 55:993–1000. https://doi.org/10.1111/j.1532-5415.2007.01234.x CrossRefPubMed

65.

Bakitas M, Lyons KD, Hegel MT, Balan S, Barnett KN, Brokaw FC, Byock IR, Hull JG, Li Z, Mckinstry E, Seville JL, Ahles TA (2009) The project ENABLE II randomized controlled trial to improve palliative care for rural patients with advanced cancer: baseline findings, methodological challenges, and solutions. Palliat Support Care 7:75. https://doi.org/10.1017/S1478951509000108 CrossRefPubMedPubMedCentral

66.

Zimmermann C, Swami N, Krzyzanowska M, Hannon B, Leighl N, Oza A, Moore M, Rydall A, Rodin G, Tannock I, Donner A, Lo C (2014) Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial. Lancet 383:1721–1730. https://doi.org/10.1016/S0140-6736(13)62416-2 CrossRefPubMed

67.

McDonald J, Swami N, Hannon B, Lo C, Pope A, Oza A, Leighl N, Krzyzanowska MK, Rodin G, le LW, Zimmermann C (2016) Impact of early palliative care on caregivers of patients with advanced cancer: cluster randomised trial. Ann Oncol 28:438. https://doi.org/10.1093/annonc/mdw438

68.

Patel B, Hacker E, Murks C, Ryan C (2016) Interdisciplinary pain education: moving from discipline-specific to collaborative practice. Clin J Oncol Nurs 20:636–643. https://doi.org/10.1188/16.CJON.636-643 CrossRefPubMed

69.

Canadian Hospice Palliative Care Association (2013) Innovative models of integrated hospice palliative care, the way forward initiative: an integrated palliative approach to care. http://www.hpcintegration.ca/media/40546/TWF-innovative-models-report-Eng-w

70.

Leutz WN (1999) Five laws for integrating medical and social services: lessons from the United States and the United Kingdom. Milbank Q 77:77–110 iv–vCrossRefPubMedPubMedCentral

71.

Baldonado A, Hawk O, Ormiston T, Nelson D (2017) Transitional care management in the outpatient setting. BMJ Qual Improv Reports 6:u212974.w5206. https://doi.org/10.1136/bmjquality.u212974.w5206 CrossRef

72.

Whitney HA, Nahata MC, Thordsen DJ (2008) Francke’s legacy—40 years of clinical pharmacy. Ann Pharmacother 42:121–126. https://doi.org/10.1345/aph.1K660 CrossRefPubMed

73.

Spinewine A, Dhillon S, Mallet L, Tulkens PM, Wilmotte L, Swine C (2006) Implementation of ward-based clinical pharmacy services in Belgium—description of the impact on a geriatric unit. Ann Pharmacother 40:720–728. https://doi.org/10.1345/aph.1G515 CrossRefPubMed

74.

Ise Y, Morita T, Katayama S, Kizawa Y (2014) The activity of palliative care team pharmacists in designated cancer hospitals: a nationwide survey in Japan. J Pain Symptom Manag 47:588–593. https://doi.org/10.1016/j.jpainsymman.2013.05.008 CrossRef

75.

Somers A, Spinewine A, Spriet I, Steurbaut S, Tulkens P, Hecq JD, Willems L, Robays H, Dhoore M, Yaras H, vanden Bremt I, Haelterman M (2018) Development of clinical pharmacy in Belgian hospitals through pilot projects funded by the government. Acta Clin Belg 74:1–7. https://doi.org/10.1080/17843286.2018.1462877 CrossRef

76.

Haute Autorité de Santé (2015) Initiative des HIGH 5s. Medication Reconciliation. Rapport d’expérimentation sur la mise en oeuvre de la conciliation des traitements médicamenteux par neuf établissements de santé français. https://www.has-sante.fr/portail/upload/docs/application/pdf/2015-11/rapport_dexperimentation_sur_la_mise_en_oeuvre_conciliation_des_traitements_medicamenteux_par_9_es.pdf. Accessed 17 July 2018

77.

Dickman A (2010) The place of the pharmacist in the palliative care team. Eur J Palliat Care 17:133–135

78.

Fulcrand J, Dujardin L, Lemaire A (2017) Pharmacie clinique au sein d’un pôle médicochirurgical : l’expérience originale du centre hospitalier de Valenciennes - Techniques hospitalières. Tech Hosp médico-sociales Sanit 766:16–19

79.

Patel H, Gurumurthy P (2017) Implementation of clinical pharmacy services in an academic oncology practice in India. J Oncol Pharm Pract 107815521773968:369–381. https://doi.org/10.1177/1078155217739684 CrossRef

80.

Jackson K, Letton C, Maldonado A, Bodiford A, Sion A, Hartwell R, Graham A, Bondarenka C, Uber L (2018) A pilot study to assess the pharmacy impact of implementing a chemotherapy-induced nausea or vomiting collaborative disease therapy management in the outpatient oncology clinics. J Oncol Pharm Pract 107815521876562:847–854. https://doi.org/10.1177/1078155218765629 CrossRef

81.

Fulcrand J, Delvoye J, Boursier A, Evrard M, Dujardin L, Ferret L, Barrascout E, Lemaire A (2018) Place du pharmacien clinicien dans la prise en charge des patients en soins palliatifs. J Pain Symptom Manag 56:101–102. https://doi.org/10.1016/j.jpainsymman.2018.10.343 CrossRef

82.

Dujardin L, Fulcrand J, Lemaire A (2017) Pharmacie clinique en soins de support et palliatifs. La synergie du binôme médecin-pharmacien en consultation. Tech Hosp médico-sociales Sanit 766:13–15

83.

George PP, Molina JAD, Cheah J et al (2010) The evolving role of the community pharmacist in chronic disease management - a literature review. Ann Acad Med Singap 39:861–867PubMed

84.

Lemaire A (2014) TéléPallia : La télémédecine au service du déploiement des Equipes mobiles de soins palliatifs en Etablissements d’hébergement pour personnes âgées dépendantes, en France Rev Int soins palliatifs 29:145. https://doi.org/10.3917/inka.144.0145

85.

Ohannessian R, Guettier C, Lemaire A, Denis F, Ottavy F, Galateau Salle F, Gutierrez M (2017) L’utilisation de la télémédecine pour la prise en charge du cancer en France en 2016. Eur Res Telemed / La Rech Eur en Télémédecine 6:44. https://doi.org/10.1016/J.EURTEL.2017.02.037 CrossRef

86.

European Parliament and Council. Decision no 1350/2007/ec of the European parliament and of the council of 23 October 2007 establishing a second programme of Community action in the field of health (2008–13). http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2007:301:0003:0013:EN:PDF. Accessed 17 July 2018

87.

Rojahn K, Laplante S, Sloand J, Main C, Ibrahim A, Wild J, Sturt N, Areteou T, Johnson KI (2016) Remote monitoring of chronic diseases: a landscape assessment of policies in four European countries. PLoS One 11:0155738. https://doi.org/10.1371/journal.pone.0155738 CrossRef

88.

Krupinski E, Nypaver M, Poropatich R, Ellis D, Safwat R, Sapci H (2002) Telemedicine/telehealth: an international perspective. Clinical applications in telemedicine/telehealth. Telemed J e-Health 8:13–34. https://doi.org/10.1089/15305620252933374 CrossRefPubMed

89.

Sardin B, Lemaire A, Terrier G et al (2014) Appliquer la culture palliative au champ des maladies chroniques : le concept de médecine exhaustive. Éthique et santé 11:138–151CrossRef

Title: Opening up disruptive ways of management in cancer pain: the concept of multimorphic pain
Authors: Antoine Lemaire
Brigitte George
Caroline Maindet
Alexis Burnod
Gilles Allano
Christian Minello
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Keyword: Care
Published in: Supportive Care in Cancer / Issue 8/2019
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-019-04831-z

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Method

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 8/2019

Opioids in cancer-related pain: current situation and outlook

Strategies of complementary and integrative therapies in cancer-related pain—attaining exhaustive cancer pain management

Effectiveness and safety of the pre-prescription of garenoxacin in comparison to moxifloxacin for low-risk febrile neutropenia in breast cancer patients undergoing adjuvant and neoadjuvant chemotherapy

Adoption and implementation of a web-based self-management application “Oncokompas” in routine cancer care: a national pilot study

Association between glycemic control, age, and outcomes among intensively treated patients with acute myeloid leukemia

High concentration of topical amitriptyline for treating chemotherapy-induced neuropathies

Keynote webinar | Spotlight on antibody–drug conjugates in cancer