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01-05-2019 | Original Article

Safety of oral hydration after cisplatin infusion in an outpatient lung cancer unit

Authors: Florent Puisset, Laurence Bigay-Game, Marie Noëlle Paludetto, Audrey Martel, Sophie Perriat, Audrey Rabeau, Jean Marie Canonge, Julien Mazieres

Published in: Supportive Care in Cancer | Issue 5/2019

Abstract

Purpose

Hydration is needed before and after cisplatin infusion for reducing the risk of nephrotoxicity. Even though there is no standard regimen, patients receive mostly intravenous hydration before and after cisplatin leading hospitalization during at least one night. Since the feasibility has been published, oral hydration after cisplatin was implemented in our practice. The safety of this new way of hydration needs to be assessed in clinical practice.

Methods

We collected medical records from patients treated by cisplatin for lung cancer in our unit between 2010 and 2016. We retrospectively analyzed the incidence of cisplatin induced nephrotoxicity between after and before the change of hydration regimen.

Results

Our patient cohort included 241 patients hydrated by intravenous regimen (IV/IV group) and 276 patient hydrated by intravenous and oral regimen (IV/PO group). Grade ≥ 1 nephrotoxicity occurred in 39.4 and 25.7% in the IV/IV and IV/PO groups respectively (p = 0.001). Age over 70 at baseline was a predictive factor for nephrotoxicity, but not estimated glomerular filtration rate nor cisplatin-associated drugs. After a multivariate analysis, age remained a predictive factor for nephrotoxicity and IV/PO hydration associated with a decrease in nephrotoxic risk.

Conclusion

The implementation of oral hydration in our practice was not associated with an increase in nephrotoxicity. Our observation based on large data from clinical practice shows that oral hydration after cisplatin is safe.

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Title: Safety of oral hydration after cisplatin infusion in an outpatient lung cancer unit
Authors: Florent Puisset
Laurence Bigay-Game
Marie Noëlle Paludetto
Audrey Martel
Sophie Perriat
Audrey Rabeau
Jean Marie Canonge
Julien Mazieres
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 5/2019
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4415-7

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