Skip to main content
Top
Published in: Supportive Care in Cancer 9/2018

Open Access 01-09-2018 | Review Article

Can early palliative care with anticancer treatment improve overall survival and patient-related outcomes in advanced lung cancer patients? A review of the literature

Authors: Massimo Ambroggi, Claudia Biasini, Ilaria Toscani, Elena Orlandi, Raffaella Berte, Martina Mazzari, Luigi Cavanna

Published in: Supportive Care in Cancer | Issue 9/2018

Login to get access

Abstract

Purpose

Metastatic non-small-cell lung cancer (NSCLC), the leading cause of death from cancer worldwide, is a debilitating disease that results in a high burden of symptoms and poor quality of life; the estimated prognosis after the diagnosis has been established was less than 1 year until some years ago. At the present, the new targeted therapies and immunotherapy are changing the course of the disease. However, advanced NSCLC remains an incurable disease, with a poor prognosis for the majority of the affected patients, so that quality of life and relief from symptoms are primary objectives of treatment. Some evidences suggest that early palliative care (EPC) for these patients can improve quality of life and even survival.

Design

A systematic review of the studies evaluating the impact on objective and on patient-reported outcomes of the introduction of EPC in opposition to standard care (SC), for advanced lung cancer patients, was performed. Because of the small number of studies conducted in this area, retrospective studies were also considered for the review.

Results

Five studies were included because they matched the inclusion criteria previously defined as relevant for the study. The review found that both survival and quality of life were better for patients included in EPC groups.

Conclusions

While results of the studies included in this review are not always comparable because different methods and scales have been used, there is enough evidence for clinical oncologists to implement the use of EPC in clinical practice for advanced lung cancer patients.
Literature
1.
go back to reference Dalal S, Del Fabbro E, Bruera E (2006) Symptom control in palliative care: part I—oncology as a paradigmatic example. J Palliat Med 9:391–408CrossRefPubMed Dalal S, Del Fabbro E, Bruera E (2006) Symptom control in palliative care: part I—oncology as a paradigmatic example. J Palliat Med 9:391–408CrossRefPubMed
4.
go back to reference Mount BM (1976) The problem of caring for the dying in a general hospital; the palliative care unit as a possible solution. Can Med Assoc J 115:119–121PubMedPubMedCentral Mount BM (1976) The problem of caring for the dying in a general hospital; the palliative care unit as a possible solution. Can Med Assoc J 115:119–121PubMedPubMedCentral
5.
go back to reference Bruera E, Sweeney C (2002) Palliative care models: international perspective. J Palliat Med 5:319–327CrossRefPubMed Bruera E, Sweeney C (2002) Palliative care models: international perspective. J Palliat Med 5:319–327CrossRefPubMed
6.
go back to reference Higginson IJ, Finlay I, Goodwin DM, Cook AM, Hood K, Edwards AGK, Douglas HR, Norman CE (2002) Do hospital-based palliative teams improve care for patients or families at the end of life? J Pain Symptom Manag 23:96–106CrossRef Higginson IJ, Finlay I, Goodwin DM, Cook AM, Hood K, Edwards AGK, Douglas HR, Norman CE (2002) Do hospital-based palliative teams improve care for patients or families at the end of life? J Pain Symptom Manag 23:96–106CrossRef
7.
go back to reference Higginson IJ, Finlay IG, Goodwin DM, Hood K, Edwards AGK, Cook A, Douglas HR, Normand CE (2003) Is there evidence that palliative care teams alter end-of-life experiences of patients and their caregivers? J Pain Symptom Mange 25:150–168CrossRef Higginson IJ, Finlay IG, Goodwin DM, Hood K, Edwards AGK, Cook A, Douglas HR, Normand CE (2003) Is there evidence that palliative care teams alter end-of-life experiences of patients and their caregivers? J Pain Symptom Mange 25:150–168CrossRef
9.
go back to reference Hui D, Elsayem A, Palla S, de la Cruz M, Li Z, Yennurajalingam S, Bruera E (2010) Discharge outcomes and survival of patients with advanced cancer admitted to an acute palliative care unit at a comprehensive cancer center. J Palliat Med 13:49–57CrossRefPubMedPubMedCentral Hui D, Elsayem A, Palla S, de la Cruz M, Li Z, Yennurajalingam S, Bruera E (2010) Discharge outcomes and survival of patients with advanced cancer admitted to an acute palliative care unit at a comprehensive cancer center. J Palliat Med 13:49–57CrossRefPubMedPubMedCentral
10.
go back to reference Braiteh F, El Osta B, Palmer JL et al (2007) Characteristics, findings, and outcomes of palliative care inpatient consultations at a comprehensive cancer center. J Palliat Med 10:948–955CrossRefPubMed Braiteh F, El Osta B, Palmer JL et al (2007) Characteristics, findings, and outcomes of palliative care inpatient consultations at a comprehensive cancer center. J Palliat Med 10:948–955CrossRefPubMed
11.
go back to reference Strasser F, Sweeney C, Willey J, Benisch-Tolley S, Palmer JL, Bruera E (2004) Impact of a half-day multidisciplinary symptom control and palliative care outpatient clinic in a comprehensive cancer center on recommendations, symptom intensity, and patient satisfaction: a retrospective descriptive study. J Pain Symptom Manag 27:481–491CrossRef Strasser F, Sweeney C, Willey J, Benisch-Tolley S, Palmer JL, Bruera E (2004) Impact of a half-day multidisciplinary symptom control and palliative care outpatient clinic in a comprehensive cancer center on recommendations, symptom intensity, and patient satisfaction: a retrospective descriptive study. J Pain Symptom Manag 27:481–491CrossRef
12.
go back to reference Osta Be PJL, Paraskevopoulos T et al (2008) Interval between first palliative consult and death in patients diagnosed with advanced cancer at a comprehensive cancer center. J Palliat Med 11:51–57CrossRefPubMed Osta Be PJL, Paraskevopoulos T et al (2008) Interval between first palliative consult and death in patients diagnosed with advanced cancer at a comprehensive cancer center. J Palliat Med 11:51–57CrossRefPubMed
13.
go back to reference Cheng WW, Willey J, Palmer JL, Zhang T, Bruera E (2005) Interval between palliative care referral and death among patients treated at a comprehensive cancer center. J Palliat Med 8:1025–1032CrossRefPubMed Cheng WW, Willey J, Palmer JL, Zhang T, Bruera E (2005) Interval between palliative care referral and death among patients treated at a comprehensive cancer center. J Palliat Med 8:1025–1032CrossRefPubMed
14.
go back to reference Morita T, Akechi T, Ikenaga M, Kizawa Y, Kohara H, Mukaiyama T, Nakaho T, Nakashima N, Shima Y, Matsubara T, Uchitomi Y (2005) Late referrals to specialized palliative care service in Japan. J Clin Oncol 23:2637–2644CrossRefPubMed Morita T, Akechi T, Ikenaga M, Kizawa Y, Kohara H, Mukaiyama T, Nakaho T, Nakashima N, Shima Y, Matsubara T, Uchitomi Y (2005) Late referrals to specialized palliative care service in Japan. J Clin Oncol 23:2637–2644CrossRefPubMed
15.
go back to reference Morita T, Miyashita M, Tsuneto S, Sato K, Shima Y (2009) Late referrals to palliative care units in Japan: nationwide follow-up survey and effects of palliative care team involvement after the cancer control act. J Pain Symptom Manag 38:191–196CrossRef Morita T, Miyashita M, Tsuneto S, Sato K, Shima Y (2009) Late referrals to palliative care units in Japan: nationwide follow-up survey and effects of palliative care team involvement after the cancer control act. J Pain Symptom Manag 38:191–196CrossRef
16.
go back to reference Bakitas M, Lyons KD, Hegel MT, Balan S, Barnett KN, Brokaw FC, Byock IR, Hull JG, Li Z, Mckinstry E, Seville JL, Ahles TA (2009) The project ENABLE II randomized controlled trial to improve palliative care for rural patients with advanced cancer: baseline findings, methodological challenges, and solutions. Palliat Support Care 7:75–86CrossRefPubMedPubMedCentral Bakitas M, Lyons KD, Hegel MT, Balan S, Barnett KN, Brokaw FC, Byock IR, Hull JG, Li Z, Mckinstry E, Seville JL, Ahles TA (2009) The project ENABLE II randomized controlled trial to improve palliative care for rural patients with advanced cancer: baseline findings, methodological challenges, and solutions. Palliat Support Care 7:75–86CrossRefPubMedPubMedCentral
17.
go back to reference Wright AA, Zhang B, Ray A, Mack JW, Trice E, Balboni T, Mitchell SL, Jackson VA, Block SD, Maciejewski PK, Prigerson HG (2008) Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA 300:1665–1673CrossRefPubMedPubMedCentral Wright AA, Zhang B, Ray A, Mack JW, Trice E, Balboni T, Mitchell SL, Jackson VA, Block SD, Maciejewski PK, Prigerson HG (2008) Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA 300:1665–1673CrossRefPubMedPubMedCentral
18.
go back to reference Bruera E, Hui D (2010) Integrating supportive and palliative care in the trajectory of cancer: establishing goals and models of care. J Clin Oncol 28(25):4013–4017CrossRefPubMed Bruera E, Hui D (2010) Integrating supportive and palliative care in the trajectory of cancer: establishing goals and models of care. J Clin Oncol 28(25):4013–4017CrossRefPubMed
19.
go back to reference Freireich EJ, Kurzrock R (2009) The role of investigational therapy in management of patients with advanced metastatic malignancy. J Clin Oncol 27:304–306CrossRefPubMed Freireich EJ, Kurzrock R (2009) The role of investigational therapy in management of patients with advanced metastatic malignancy. J Clin Oncol 27:304–306CrossRefPubMed
20.
go back to reference Hui D, Elsayem A, Li Z, de la Cruz M, Palmer JL, Bruera E (2010) Antineopalstic therapy use in patients with advanced cancer admitted to an acute palliative care unit at a comprehensive cancer center: a simultaneous care model. Cancer 116:2036–2043CrossRefPubMedPubMedCentral Hui D, Elsayem A, Li Z, de la Cruz M, Palmer JL, Bruera E (2010) Antineopalstic therapy use in patients with advanced cancer admitted to an acute palliative care unit at a comprehensive cancer center: a simultaneous care model. Cancer 116:2036–2043CrossRefPubMedPubMedCentral
21.
go back to reference Hui D, Parsons HA, Nguywen L et al (2010) Timing of palliative care referral and symptom burden in phase I cancer patients: a retrospective cohort study. Cancer 116:4402–4409CrossRefPubMedPubMedCentral Hui D, Parsons HA, Nguywen L et al (2010) Timing of palliative care referral and symptom burden in phase I cancer patients: a retrospective cohort study. Cancer 116:4402–4409CrossRefPubMedPubMedCentral
22.
go back to reference Fadul N, Elsayem A, Palmer JL, del Fabbro E, Swint K, Li Z, Poulter V, Bruera E (2009) Supportive versus palliative care: what’s in a name?—a survey of medical oncologists and midlevel providers at a comprehensive cancer center. Cancer 115:2013–2021CrossRefPubMed Fadul N, Elsayem A, Palmer JL, del Fabbro E, Swint K, Li Z, Poulter V, Bruera E (2009) Supportive versus palliative care: what’s in a name?—a survey of medical oncologists and midlevel providers at a comprehensive cancer center. Cancer 115:2013–2021CrossRefPubMed
23.
go back to reference Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics. CA Cancer J Clin 59:225–249CrossRefPubMed Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics. CA Cancer J Clin 59:225–249CrossRefPubMed
24.
go back to reference Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742CrossRefPubMed Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742CrossRefPubMed
25.
go back to reference Hopwood P, Stephens RJ (2000) Depression in patients with lung cancer: prevalence and risk factors derived from quality-of-life data. J Clin Oncol 18:893–903CrossRefPubMed Hopwood P, Stephens RJ (2000) Depression in patients with lung cancer: prevalence and risk factors derived from quality-of-life data. J Clin Oncol 18:893–903CrossRefPubMed
26.
go back to reference Hopwood P, Stephens RJ (1995) Symptoms at presentation for treatment in patients with lung cancer: implications for the evaluation of palliative treatment. Br J Cancer 71:633–636CrossRefPubMedPubMedCentral Hopwood P, Stephens RJ (1995) Symptoms at presentation for treatment in patients with lung cancer: implications for the evaluation of palliative treatment. Br J Cancer 71:633–636CrossRefPubMedPubMedCentral
27.
go back to reference Lutz S, Norrel R, Bertucio C et al (2001) Symptom frequency and severity in patients with metastatic or locally recurrent lung cancer: a prospective study using the lung cancer symptom scale in a community hospital. J Palliat Med 4:157–165CrossRefPubMed Lutz S, Norrel R, Bertucio C et al (2001) Symptom frequency and severity in patients with metastatic or locally recurrent lung cancer: a prospective study using the lung cancer symptom scale in a community hospital. J Palliat Med 4:157–165CrossRefPubMed
28.
go back to reference Mok TS (2009) Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 36:947–957CrossRef Mok TS (2009) Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 36:947–957CrossRef
29.
go back to reference Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, Palmero R, Garcia-Gomez R, Pallares C, Sanchez JM, Porta R, Cobo M, Garrido P, Longo F, Moran T, Insa A, de Marinis F, Corre R, Bover I, Illiano A, Dansin E, de Castro J, Milella M, Reguart N, Altavilla G, Jimenez U, Provencio M, Moreno MA, Terrasa J, Muñoz-Langa J, Valdivia J, Isla D, Domine M, Molinier O, Mazieres J, Baize N, Garcia-Campelo R, Robinet G, Rodriguez-Abreu D, Lopez-Vivanco G, Gebbia V, Ferrera-Delgado L, Bombaron P, Bernabe R, Bearz A, Artal A, Cortesi E, Rolfo C, Sanchez-Ronco M, Drozdowskyj A, Queralt C, de Aguirre I, Ramirez JL, Sanchez JJ, Molina MA, Taron M, Paz-Ares L, Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica (2012) Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicenter, open-label, randomized phase 3 trial. Lancet Oncol 13:239–246CrossRefPubMed Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, Palmero R, Garcia-Gomez R, Pallares C, Sanchez JM, Porta R, Cobo M, Garrido P, Longo F, Moran T, Insa A, de Marinis F, Corre R, Bover I, Illiano A, Dansin E, de Castro J, Milella M, Reguart N, Altavilla G, Jimenez U, Provencio M, Moreno MA, Terrasa J, Muñoz-Langa J, Valdivia J, Isla D, Domine M, Molinier O, Mazieres J, Baize N, Garcia-Campelo R, Robinet G, Rodriguez-Abreu D, Lopez-Vivanco G, Gebbia V, Ferrera-Delgado L, Bombaron P, Bernabe R, Bearz A, Artal A, Cortesi E, Rolfo C, Sanchez-Ronco M, Drozdowskyj A, Queralt C, de Aguirre I, Ramirez JL, Sanchez JJ, Molina MA, Taron M, Paz-Ares L, Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica (2012) Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicenter, open-label, randomized phase 3 trial. Lancet Oncol 13:239–246CrossRefPubMed
30.
go back to reference Shaw AT, Kim DW, Nakagawa K, Seto T, Crinó L, Ahn MJ, de Pas T, Besse B, Solomon BJ, Blackhall F, Wu YL, Thomas M, O'Byrne KJ, Moro-Sibilot D, Camidge DR, Mok T, Hirsh V, Riely GJ, Iyer S, Tassell V, Polli A, Wilner KD, Jänne PA (2013) Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 368:2385–2394CrossRefPubMed Shaw AT, Kim DW, Nakagawa K, Seto T, Crinó L, Ahn MJ, de Pas T, Besse B, Solomon BJ, Blackhall F, Wu YL, Thomas M, O'Byrne KJ, Moro-Sibilot D, Camidge DR, Mok T, Hirsh V, Riely GJ, Iyer S, Tassell V, Polli A, Wilner KD, Jänne PA (2013) Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 368:2385–2394CrossRefPubMed
31.
go back to reference Solomon BJ, Mok T, Kim DW, Wu YL, Nakagawa K, Mekhail T, Felip E, Cappuzzo F, Paolini J, Usari T, Iyer S, Reisman A, Wilner KD, Tursi J, Blackhall F, PROFILE 1014 Investigators (2014) PROFILE 1014 investigators. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med 371:2167–2177CrossRefPubMed Solomon BJ, Mok T, Kim DW, Wu YL, Nakagawa K, Mekhail T, Felip E, Cappuzzo F, Paolini J, Usari T, Iyer S, Reisman A, Wilner KD, Tursi J, Blackhall F, PROFILE 1014 Investigators (2014) PROFILE 1014 investigators. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med 371:2167–2177CrossRefPubMed
32.
go back to reference Mazieres J, Zalcman G, Crinò L et al (2015) Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: results from the EUROS1 cohort. J Clin Oncol 33:992–999CrossRefPubMed Mazieres J, Zalcman G, Crinò L et al (2015) Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: results from the EUROS1 cohort. J Clin Oncol 33:992–999CrossRefPubMed
34.
go back to reference Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WEE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, Waterhouse D, Ready N, Gainor J, Arén Frontera O, Havel L, Steins M, Garassino MC, Aerts JG, Domine M, Paz-Ares L, Reck M, Baudelet C, Harbison CT, Lestini B, Spigel DR (2015) Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 373:123–135CrossRefPubMedPubMedCentral Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WEE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, Waterhouse D, Ready N, Gainor J, Arén Frontera O, Havel L, Steins M, Garassino MC, Aerts JG, Domine M, Paz-Ares L, Reck M, Baudelet C, Harbison CT, Lestini B, Spigel DR (2015) Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 373:123–135CrossRefPubMedPubMedCentral
35.
go back to reference Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, Barlesi F, Kohlhäufl M, Arrieta O, Burgio MA, Fayette J, Lena H, Poddubskaya E, Gerber DE, Gettinger SN, Rudin CM, Rizvi N, Crinò L, Blumenschein GR Jr, Antonia SJ, Dorange C, Harbison CT, Graf Finckenstein F, Brahmer JR (2015) Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung Cancer. N Engl J Med 373:1627–1639CrossRefPubMedPubMedCentral Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, Barlesi F, Kohlhäufl M, Arrieta O, Burgio MA, Fayette J, Lena H, Poddubskaya E, Gerber DE, Gettinger SN, Rudin CM, Rizvi N, Crinò L, Blumenschein GR Jr, Antonia SJ, Dorange C, Harbison CT, Graf Finckenstein F, Brahmer JR (2015) Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung Cancer. N Engl J Med 373:1627–1639CrossRefPubMedPubMedCentral
36.
go back to reference Herbst RS, Baas P, Kim DW, Felip E, Pérez-Gracia JL, Han JY, Molina J, Kim JH, Arvis CD, Ahn MJ, Majem M, Fidler MJ, de Castro G Jr, Garrido M, Lubiniecki GM, Shentu Y, Im E, Dolled-Filhart M, Garon EB (2016) Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomized controlled trial. Lancet 387:1540–1550CrossRefPubMed Herbst RS, Baas P, Kim DW, Felip E, Pérez-Gracia JL, Han JY, Molina J, Kim JH, Arvis CD, Ahn MJ, Majem M, Fidler MJ, de Castro G Jr, Garrido M, Lubiniecki GM, Shentu Y, Im E, Dolled-Filhart M, Garon EB (2016) Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomized controlled trial. Lancet 387:1540–1550CrossRefPubMed
37.
go back to reference Temel JS, Jackson VA, Billings JA, Dahlin C, Block SD, Buss MK, Ostler P, Fidias P, Muzikansky A, Greer JA, Pirl WF, Lynch TJ (2007) Phase II study: integrated palliative care in newly diagnosed advanced non-small-cell lung cancer patients. J Clin Oncol 25(17):2377–2382CrossRefPubMed Temel JS, Jackson VA, Billings JA, Dahlin C, Block SD, Buss MK, Ostler P, Fidias P, Muzikansky A, Greer JA, Pirl WF, Lynch TJ (2007) Phase II study: integrated palliative care in newly diagnosed advanced non-small-cell lung cancer patients. J Clin Oncol 25(17):2377–2382CrossRefPubMed
38.
go back to reference Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62(10):e1–e34 Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62(10):e1–e34
39.
go back to reference Zimmermann C, Swami N, Kryzanowska M et al (2014) Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial. Lancet 383:1721–1730CrossRefPubMed Zimmermann C, Swami N, Kryzanowska M et al (2014) Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial. Lancet 383:1721–1730CrossRefPubMed
40.
go back to reference Nieder C, Tollali T, Haukland E et al (2016) Impact of early palliative interventions on the outcomes of care for patients with non-small cell lung cancer. Support Care Cancer 24:4385–4391CrossRefPubMed Nieder C, Tollali T, Haukland E et al (2016) Impact of early palliative interventions on the outcomes of care for patients with non-small cell lung cancer. Support Care Cancer 24:4385–4391CrossRefPubMed
41.
go back to reference King JD, Eikhoff J, Traynor A et al (2016) Integrated onco-palliative care associated with prolonged survival compared to standard care for patients with advanced lung cancer: a retrospective review. J Pain Symptom Manag 51(6):1027–1032CrossRef King JD, Eikhoff J, Traynor A et al (2016) Integrated onco-palliative care associated with prolonged survival compared to standard care for patients with advanced lung cancer: a retrospective review. J Pain Symptom Manag 51(6):1027–1032CrossRef
42.
go back to reference Temel JS, Greer JA, El-Jawahri A et al (2017) Effects of early palliative care in patients with lung and GI cancer: a randomized clinical trial. J Clin Oncol 35(8):834–841CrossRefPubMed Temel JS, Greer JA, El-Jawahri A et al (2017) Effects of early palliative care in patients with lung and GI cancer: a randomized clinical trial. J Clin Oncol 35(8):834–841CrossRefPubMed
43.
go back to reference Sabesan S, Piliouras P (2009) Disparity in cancer survival between urban and rural patients—how can clinicians help reduce it? Rural Remote Health 9:1146–1150PubMed Sabesan S, Piliouras P (2009) Disparity in cancer survival between urban and rural patients—how can clinicians help reduce it? Rural Remote Health 9:1146–1150PubMed
44.
go back to reference Ambroggi M, Biasini C, Del Giovane C et al (2015) Distance as a barrier to cancer diagnosis and treatment: review of the literature. Oncologist 20(12):1378–1385CrossRefPubMedPubMedCentral Ambroggi M, Biasini C, Del Giovane C et al (2015) Distance as a barrier to cancer diagnosis and treatment: review of the literature. Oncologist 20(12):1378–1385CrossRefPubMedPubMedCentral
45.
go back to reference Zagonel V, Franciosi V, Brunello A, Biasco G, Broglia C, Cattaneo D, Cavanna L, Corsi D, Farina G, Fioretto L, Gamucci T, Lanzetta G, Magarotto R, Maltoni M, Marchetti P, Massa E, Mastromauro C, Melotti B, Meriggi F, Nacci A, Pavese I, Piva E, Quirino M, Roselli M, Sacco C, Tonini G, Trentin L, Ucci G, Labianca R, Gori S, Pinto C, Cascinu S, AIOM Simultaneous & Continuous Care (SCC), Task Force: ESMO Italian DCs (2017) Position paper of the Italian Association of Medical Oncology on early palliative care in oncology practice (simultaneous care). Tumori 103(1):9–14CrossRefPubMed Zagonel V, Franciosi V, Brunello A, Biasco G, Broglia C, Cattaneo D, Cavanna L, Corsi D, Farina G, Fioretto L, Gamucci T, Lanzetta G, Magarotto R, Maltoni M, Marchetti P, Massa E, Mastromauro C, Melotti B, Meriggi F, Nacci A, Pavese I, Piva E, Quirino M, Roselli M, Sacco C, Tonini G, Trentin L, Ucci G, Labianca R, Gori S, Pinto C, Cascinu S, AIOM Simultaneous & Continuous Care (SCC), Task Force: ESMO Italian DCs (2017) Position paper of the Italian Association of Medical Oncology on early palliative care in oncology practice (simultaneous care). Tumori 103(1):9–14CrossRefPubMed
Metadata
Title
Can early palliative care with anticancer treatment improve overall survival and patient-related outcomes in advanced lung cancer patients? A review of the literature
Authors
Massimo Ambroggi
Claudia Biasini
Ilaria Toscani
Elena Orlandi
Raffaella Berte
Martina Mazzari
Luigi Cavanna
Publication date
01-09-2018
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 9/2018
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-018-4184-3

Other articles of this Issue 9/2018

Supportive Care in Cancer 9/2018 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine